Tag: M.W=150-200

Goswami, Shyamaprosad published the artcileThree-point hydrogen bondings of carboxyl group in recognition of carboxylic acid and amino acid with designed synthetic receptors, Synthetic Route of 14903-78-7, the publication is Journal of the Indian Chemical Society (1999), 76(11-12), 661-664, database is CAplus.

The binding of carboxylic acids and amino acids were reported with designed synthetic receptors. The 3-point binding of carboxylic acids (with receptors I–III) was used to bind acetylglycine with receptor 6.

Journal of the Indian Chemical Society published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Synthetic Route of 14903-78-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Goswami, Shyamaprosad published the artcileN-Bromosuccinimide reactions of some heterocycles in the presence or absence of water: an overview of ring versus side chain bromination for the synthesis of important brominated heterocyclic synthons, COA of Formula: C10H10N2, the publication is Journal of Heterocyclic Chemistry (2001), 38(1), 173-178, database is CAplus.

Reactions of various heterocycles with N-bromosuccinimide in the presence or absence of water have been studied for side chain vs. ring bromination to afford some new and important heterocyclic synthons. Interestingly, the N-bromosuccinimide reaction of I in the presence of perchloric acid, a new condition, affords exclusively the new dibromoaminopicoline II, which is not obtained by other presently studied methods.

Journal of Heterocyclic Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, COA of Formula: C10H10N2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Goswami, S. published the artcileRecognition of insoluble tartaric acid in chloroform, Application In Synthesis of 14903-78-7, the publication is Tetrahedron (2001), 57(23), 4987-4993, database is CAplus.

Simple receptors for the recognition and solubilization of insoluble tartaric acid in chloroform were designed and synthesized for the 1st time. Receptors N-(7-Methyl-[1,8]naphthylridin-2-yl)-N‘-(6-methylpyridin-2-yl)isophthalamide and N,N‘-Bis(7-methyl-[1,8]naphthylridin-2-yl)isophthalamide were successful in solubilizing tartaric acid into chloroform forming a 1:1 complex, and also are useful as fluorescent probes for the detection of this substrate.

Tetrahedron published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Application In Synthesis of 14903-78-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Prakash, G. K. Surya published the artcileCopper-mediated difluoromethylation of (hetero)aryl iodides and β-styryl Halides with tributyl(difluoromethyl)stannane, Recommanded Product: 1-(Difluoromethyl)naphthalene, the publication is Angewandte Chemie, International Edition (2012), 51(48), 12090-12094, database is CAplus and MEDLINE.

An efficient method for preparation of difluoromethyl substituted arenes, heteroarenes, and styrenes via copper-mediated difluoromethylation of aryl iodides and styrenyl halides is described. The difluoromethyl donor was synthesized from trifluoromethyl trifluoromethylsilane and trialkyltin hydrides. The reaction mechanism was explored by computational chem.

Angewandte Chemie, International Edition published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C11H8F2, Recommanded Product: 1-(Difluoromethyl)naphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Hendricker, D. G. published the artcileComplexes of 1,8-naphthyridines. VIII. Complexes of 2,7-dimethyl-1,8-naphthyridine with rare earth nitrates, Formula: C10H10N2, the publication is Journal of Inorganic and Nuclear Chemistry (1972), 34(6), 1949-54, database is CAplus.

Rare earth nitrate complexes of the type M(2,7-dmn-apy)2(NO3)3 (M = Y, La-Yb 2,7-dmnapy = 2,7-dimethyl-1,8-naphthyridine) were synthesized. The compounds were characterized by elemental analyses, molar conductances, magnetic moments, and ir (4000-200 cm-1). The molar conductance and ir spectral data show that all nitrate groups are coordinated to the metals. From this and crystallographic data of an analogous compound the complexes appear to be ten-coordinate.

Journal of Inorganic and Nuclear Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Formula: C10H10N2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Wang, Wei published the artcileBorane-catalyzed metal-free hydrogenation of 2,7-disubstituted 1,8-naphthyridines, Application In Synthesis of 14903-78-7, the publication is Organic & Biomolecular Chemistry (2016), 14(28), 6683-6686, database is CAplus and MEDLINE.

Metal-free hydrogenation of 2,7-disubstituted 1,8-naphthyridines was successfully realized for the first time using in situ generated borane catalysts under mild conditions to furnish 1,2,3,4-tetrahydro-1,8-naphthyridine derivatives in 83-98% yields. Significantly, up to 74% ee was achieved for the corresponding asym. hydrogenation reactions.

Organic & Biomolecular Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C8H11BO2, Application In Synthesis of 14903-78-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Kuzelka, Jane published the artcileModeling the Syn Disposition of Nitrogen Donors at the Active Sites of Carboxylate-Bridged Diiron Enzymes. Enforcing Dinuclearity and Kinetic Stability with a 1,2-Diethynylbenzene-Based Ligand, Formula: C10H10N2, the publication is Inorganic Chemistry (2003), 42(26), 8652-8662, database is CAplus and MEDLINE.

The syn coordination of histidine residues at the active sites of several carboxylate-rich nonheme diiron enzymes was difficult to reproduce with small mol. model compounds Ligands derived from 1,8-naphthyridine, phthalazine, and 1,2-diethynylbenzene were employed to mimic this geometric feature. The preassembled diiron(II) complex [Fe₂(μ-O₂CAr^Tol)₂(O₂CAr^Tol)₂(THF)₂] (1), where Ar^TolCO₂^– is the sterically hindered carboxylate 2,6-di(p-tolyl)benzoate, served as a convenient starting material for the preparation of Fe(II) complexes, all of which were crystallog. characterized. Use of the ligand 2,7-dimethyl-1,8-naphthyridine (Me₂-napy) afforded mononuclear [Fe(O₂CAr^Tol)₂(Me₂-napy)] (2), whereas dinuclear [Fe₂(μ-DMP)(μ-O₂CAr^Tol)₂(O₂CAr^Tol)₂(THF)] (3) resulted when 1,4-dimethylphthalazine (DMP) was employed. The dinuclear core of compound 3 is kinetically labile, as evidenced by the formation of [Fe(O₂CAr^Tol)₂(vpy)₂] (4) upon addition of 2-vinylpyridine (vpy). The diiron analog of 4, [Fe₂(μ-O₂CAr^Tol)₂(O₂CAr^Tol)₂(vpy)₂] (5), was prepared directly from 1. When the sterically more demanding ligand 2,6-di(4-tert-butylphenyl)benzoate (Ar^4-tBuPhCO₂^–) was used, mononuclear [Fe(O₂CAr^4-tBuPh)₂(THF)₂] (6) and [Fe(O₂CAr^4-tBuPh)₂(DMP)₂] (7) formed. The difficulty in stabilizing a dinuclear core with these simple (N)₂-donor ligands was circumvented by preparing a family of 1,2-diethynylbenzene-based ligands, from which were readily assembled [Fe₂(Et₂BCQEB^Et)(μ-O₂CAr^Tol)₃](OTf) (15) and [Cu₂(Et₂BCQEB^Et)(μ-I)₂] (16), where Et₂BCQEB^Et is 1,2-bis(3-ethynyl-8-carboxylatequinoline)benzene Et ester. The Et₂BCQEB^Et framework provides both structural flexibility and the desired syn N donor geometry, thus serving as a good 1st-generation ligand in this class.

Inorganic Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Formula: C10H10N2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Goswami, Shyamaprosad published the artcileSide chain bromination of mono and dimethyl heteroaromatic and aromatic compounds by solid phase N-bromosuccinimide reaction without radical initiator under microwave, Synthetic Route of 14903-78-7, the publication is Chemistry Letters (2004), 33(7), 916-917, database is CAplus.

A series of side chain mono and dibromo derivatives of mono and di-Me heteroaromatic and aromatic compounds were synthesized by one step solid phase N-bromosuccinimide (NBS) reaction without radical initiator by microwave irradiation The benzylic mono and dibromo products were exclusively preferred except in the case of 6-methylpyridine amides where nuclear and side chain bromination resulted. Naphthyridine systems gave improved yields. Synthesis of 2-pivaloylaminopterin-6-carbaldehyde is reported.

Chemistry Letters published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Synthetic Route of 14903-78-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Pandey, Pragati published the artcileA Proton-Responsive Annulated Mesoionic Carbene (MIC) Scaffold on Ir Complex for Proton/Hydride Shuttle: An Experimental and Computational Investigation on Reductive Amination of Aldehyde, Application of 2,7-Dimethyl-1,8-naphthyridine, the publication is Organometallics (2020), 39(21), 3849-3863, database is CAplus.

A Cp^*Ir(III) complex (1) bearing a proton-responsive hydroxy unit on an annulated imidazo[1,2-a][1,8]naphthyridine based mesoionic carbene scaffold was synthesized by two different synthetic routes. The mol. structure of 1 revealed an anionic lactam form of the ligand. The acid-base equilibrium between the lactam-lactim tautomers on the ligand scaffold was examined by ¹H NMR and UV-visible spectra. The pK_a of the appendage -OH group in the lactim form of 1 was estimated to assess the proton transfer property of the catalyst. The catalytic efficacy of 1 for reductive amination of aldehyde was evaluated by using three different H sources: mol. H₂, ⁱPrOH/KO^tBu combination, and HCOOH/Et₃N (5:2) azeotropic mixture The HCOOH/Et₃N (5:2) azeotropic mixture protocol is the best among the three different hydrogenation methods. Catalyst 1 hydrogenates imines chemoselectively over carbonyls under the reaction conditions. A range of aldehydes was reductively aminated to the corresponding secondary amines using the HCOOH/Et₃N (5:2) azeotropic mixture Further, catalyst 1 showed high efficiency for the reduction of a wide variety of N-heterocyclic imine derivatives The lactam-lactim tautomerization of the ligand system is proposed for direct hydrogenation, whereas only the lactam form operates in the strongly basic medium (ⁱPrOH/KO^tBu). Under HCOOH/Et₃N (5:2) conditions, the lactam scaffold is not protonated; rather, an outer-sphere hydride transfer from formate to the Ir is proposed, which is supported by ¹H NMR and DFT calculations Finally, ligand-promoted hydride transfer from metal-hydride to the protonated imine affords the corresponding amine. A close agreement between the exptl. estimated and computed thermodn./kinetic parameters gives credence to the metal-ligand cooperative mechanism for the imine hydrogenation reaction using the HCOOH/Et₃N (5:2) azeotropic mixture

Organometallics published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Application of 2,7-Dimethyl-1,8-naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Chandler, Christopher J. published the artcileThe synthesis of macrocyclic polyether-diesters incorporating 1,10-phenanthrolino and 1,8-naphthyridino subunits, COA of Formula: C10H10N2, the publication is Journal of Heterocyclic Chemistry (1982), 19(5), 1017-19, database is CAplus.

Macrocycles I (n = 2-4) and II (n = 3, 4) were prepared by treating the resp. acid chlorides with HO(CH₂CH₂O)_nH. 2,7-Dimethylnaphthylridine was prepared in 60% yield from III by thermal rearrangement to ketone IV, followed by chlorination with POCl₃ and hydrogenolysis. III was obtained by treating 6-methyl-2-pyridinamine with MeCOCH₂CO₂Et.

Journal of Heterocyclic Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, COA of Formula: C10H10N2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem