Tag: M.W=150-200

Hendricker, David G. published the artcileComplexes of 1,8-naphthyridines. II. Dialkyltin dichloride adducts of 2,7-dimethyl-1,8-naphthyridine, Name: 2,7-Dimethyl-1,8-naphthyridine, the publication is Inorganic Chemistry (1969), 8(11), 2328-30, database is CAplus.

Complexes of the type R2SnCl2L, where R = Me, Et, Pr, Bu, C5H11, Ph, C12H25, and Cl and L = 2,7-dimethyl-1,8-naphthyridine, have been prepared and characterized. A 4-member chelate ring system is exhibited in these white, air-stable complexes. The ir spectra (600-200 cm.-1) of the compounds have been recorded and assignment of the Sn-Cl and Sn-C stretching modes made. The changes in ligand and alkyltin proton magnetic resonance positions produced by complexation are examined The 117Sn-H and 119Sn-H coupling constants for the compounds, where R = Me and Et, are reported. A cis-Cl,-trans-R geometry for these complexes is inferred from the spectral data.

Inorganic Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Name: 2,7-Dimethyl-1,8-naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Miao, Wenjun published the artcileIron-Catalyzed Difluoromethylation of Arylzincs with Difluoromethyl 2-Pyridyl Sulfone, Product Details of C11H8F2, the publication is Journal of the American Chemical Society (2018), 140(3), 880-883, database is CAplus and MEDLINE.

In the presence of Fe(acac)₃ and N,N,N’,N’-tetramethylethylenediamine, arylzinc reagents (in most cases generated in situ from aryl Grignard reagents) underwent difluoromethylation reactions with difluoromethyl 2-pyridinyl sulfone at -40° to ambient temperature to yield difluoromethylarenes. Reaction of a difluoropentenyl 2-pyridinyl sulfone with an in situ-generated diarylzinc reagent yielded an arylmethyldifluorocyclopentane, implying the involvement of radical species in the iron-catalyzed difluoromethylation; the reaction was inhibited by TEMPO, BHT, and 1,4-dinitrobenzene.

Journal of the American Chemical Society published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C11H8F2, Product Details of C11H8F2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Wang, Jiaoyang published the artcileDinuclear Organoruthenium Complex for Mitochondria-Targeted Near-Infrared Imaging and Anticancer Therapy to Overcome Platinum Resistance, Quality Control of 14903-78-7, the publication is Inorganic Chemistry (2022), 61(21), 8267-8282, database is CAplus and MEDLINE.

New mononuclear and dinuclear Ru(II) coordination compounds with the 2,7-bisbenzoimidazolyl-naphthyridine ligand have been synthesized and characterized by UV-vis, NMR, and MALDI-TOF. The mol. structures for Ru(II) compounds were determined by single-crystal X-ray diffraction. With the expansion of ligand π-conjugation and the increase in the complexed Ru number, the maximum emission wavelength red-shifted from 696 to 786 nm. The binding mode between complexes and DNA was predicted by mol. docking, which is intercalations and π-π stacking interactions with the surrounding bases. The intercalation mode of DNA binding was then determined by DNA titration and ethidium bromide (EB) displacement experiments The antigrowth effects of complexes RuY (I), RuY1 (II), and RuY2 (III)were tested in HaCat (normal cells), HeLa (cervical cancer), A549 (lung cancer), and A549/DDP (cisplatin-resistant lung cancer) through the MTT assay. The dinuclear complex RuY2 was superior to mononuclear complexes and cisplatin in the cisplatin-resistant cell line. Confocal imaging proved that the subcellular localization of Ru(II) complexes was mitochondria; moreover, apoptosis was detected by flow cytometry. All three complexes showed a dose-dependent manner in all four cell lines. All Ru(II) complexes were found to have reactive oxygen species (ROS). The finding indicated that these Ru(II) complexes caused cell death by both DNA disruption and ROS. This study helps to explore the potential of the polynuclear Ru(II) complexes for the combination of NIR imaging and Pt-resistant cancer therapy.

Inorganic Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C11H15NO2, Quality Control of 14903-78-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Yoshida, Kunio published the artcileLaser-induced damage of multilayer coated optical components, Application of 1-(Difluoromethyl)naphthalene, the publication is Kaku Yugo Kenkyu (1992), 68(Suppl.), 227-33, database is CAplus.

A number of optics having high quality and high damage threshold were developed. The damage threshold of borosilicate crown glass was considerably improved. The surface roughness dependence of the laser-induced surface damage of optical glasses and the laser-induced damage of HR coating were found for the first time. These optical technologies meet the GEKKO XII Upgrade fluence requirements.

Kaku Yugo Kenkyu published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C17H20ClN3, Application of 1-(Difluoromethyl)naphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Fun, Hoong Kun published the artcile2,7-Dimethyl-1,8-naphthyridine, Computed Properties of 14903-78-7, the publication is Acta Crystallographica, Section E: Structure Reports Online (2009), 65(8), o1747, database is CAplus and MEDLINE.

The asym. unit of 2,7-di-Me-1,8-naphthyridine, C₁₀H₁₀N₂, contains 1/2-mol. with the 2 shared C atoms lying on a 2-fold rotation axis. The 1,8-naphthyridine is almost planar with a dihedral angle of 0.42(3)° between the fused pyridine rings. In the crystal, mols. are linked into infinite chains along the c axis by intermol. C-H···N H bonds, generating R₂²(8) ring motifs. The crystal structure is further stabilized by C-H···π interactions. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Computed Properties of 14903-78-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Zheng, Yu published the artcilePhosphonium Ylide-Mediated Programmable Fluorination to Access Mono- and Difluoromethylarenes, Application In Synthesis of 53731-26-3, the publication is Organic Letters, database is CAplus and MEDLINE.

Compounds bearing fluorinated moieties are pervasive in a wide range of pharmaceuticals and agrochems. The installation of fluorinated units is a persistently vital task in synthetic chem., where facile and manipulable assays are highly demanding. Herein, we establish a general and programmable fluorination strategy for the modular assembly of mono- and difluoromethylarenes through the controllable deprotonation and fluorination of phosphonium ylides. Moreover, the rational combination of the reaction sequence allows the rapid construction of diversified fluorine-containing arenes.

Organic Letters published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C23H20BN, Application In Synthesis of 53731-26-3.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

He, Guowen published the artcilePh₂S/selectfluor-promoted deoxydifluorination of aldehydes, COA of Formula: C11H8F2, the publication is Tetrahedron (2021), 131963, database is CAplus.

The installation of a HCF₂ group is a research area that has received increasing attention, and deoxydifluorination of aldehydes have served as an attractive protocol due to the wide availability of aldehydes. Herein a Ph₂S/selectfluor-promoted deoxydifluorination of aldehydes under mild conditions is described. Compared with previous deoxydifluorination methods, which usually use hazardous reagents such as SF₄, DAST and deoxo-fluor, this protocol is quite attractive because of the safe and convenient operations, and the use of easily available reagents.

Tetrahedron published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C11H8F2, COA of Formula: C11H8F2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Fuchibe, Kohei published the artcileSynthesis of (difluoromethyl)naphthalenes using the ring construction strategy: C-C bond formation on the central carbon of 1,1-difluoroallenes via Pd-catalyzed insertion, Application In Synthesis of 53731-26-3, the publication is Organic & Biomolecular Chemistry (2019), 17(20), 5047-5054, database is CAplus and MEDLINE.

The insertion of 1,1-difluoroallenes was carried out to form a C-C bond exclusively on their central carbon. O-Bromophenyl-bearing 1,1-difluoroallenes underwent intramol. insertion in the presence of a palladium catalyst. Regioselective C-C bond formation occurred to form a six-membered carbocycle, leading to pharmaceutically and agrochem. promising difluoromethylated naphthalenes.

Organic & Biomolecular Chemistry published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C11H8F2, Application In Synthesis of 53731-26-3.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Sap, Jeroen B. I. published the artcileSynthesis of ¹⁸F-difluoromethylarenes using arylboronic acids, ethyl bromofluoroacetate and [¹⁸F]fluoride, Recommanded Product: 1-(Difluoromethyl)naphthalene, the publication is Chemical Science (2019), 10(11), 3237-3241, database is CAplus and MEDLINE.

Herein, the radiosynthesis of ¹⁸F-difluoromethylarenes RCHF¹⁸F (R = 4-C₂H₅, 4-OC₆H₅, 3,5-CH₃, etc.) via the assembly of three components, a boron reagent, Et bromofluoroacetate, and cyclotron-produced non-carrier added [¹⁸F]fluoride was reported. The two key steps are a copper-catalyzed cross-coupling reaction, and a Mn-mediated ¹⁸F-fluorodecarboxylation.

Chemical Science published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C11H8F2, Recommanded Product: 1-(Difluoromethyl)naphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Zimmerman, Steven C. published the artcileAnalysis of Amidinium Guest Complexation by Comparison of Two Classes of Dendrimer Hosts Containing a Hydrogen Bonding Unit at the Core, Synthetic Route of 14903-78-7, the publication is Journal of the American Chemical Society (1998), 120(9), 2172-2173, database is CAplus.

Host-guest complexation studies were performed using two isostructural series of hosts to determine the accessibility and nanoenvironment of dendrimer cores. Association constants (K_assoc) were measured by ¹H NMR for the hydrogen bonded complexes formed between hosts and guests 3,5-di-tert-Bu benzamidinium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate and 3,5-bis(3′,5′-di-tert-butylphenylacetylene) tetrakis[3,5-bis(trifluoromethyl)phenyl]borate in 10% acetonitrile-d₃/chloroform-d. The results indicated site-specific binding between the dendrimer core and small guest mols. The on-off rates were fast on the NMR time scale even for complexes formed from high generation number hosts. Strikingly, the two series of dendritic hosts exhibited very similar complexation strengths even though the rigidity and polarity of the dendrimer interiors were quite different.

Journal of the American Chemical Society published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C17H14N2O2, Synthetic Route of 14903-78-7.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem