Van den Haak, H. J. W. published the artcileσ Adducts. Part 34. Naphthyridines. Part 18. Tele substitutions. Part 18. The amination of halo-2,7- and 1,8-naphthyridines, Computed Properties of 67988-50-5, the main research area is halonaphthyridine amination mechanism; tele substitution naphthyridine halo.
The conversion of 1-halo-2,7-naphthyridines to the corresponding 1-amino compounds with KNH2/NH3, is shown, by the use of deuterated starting compounds, to proceed via an SN(AE)ipso substitution and not via an SN(AE)tele mechanism, even though convincing evidence for the formation of tele σ-adduct, 8-amino-1-halodihydro-2,7-naphthyridine, was obtained. Using the same methods, it is shown that the conversion of 2-bromo-1,8-naphthyridine to 2-amino-1,8-naphthyridine proceeds to the extent of 40% via an odd SN(AE)tele pathway.
Recueil: Journal of the Royal Netherlands Chemical Society published new progress about Amination. 67988-50-5 belongs to class naphthyridine, name is 2,7-Naphthyridin-1(2H)-one, and the molecular formula is C8H6N2O, Computed Properties of 67988-50-5.
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem