Tag: 350.4541

Vinpocetine attenuates thioacetamide-induced liver fibrosis in rats was written by Elnfarawy, Ahmed A.;Nashy, Asmaa E.;Abozaid, Alaa M.;Komber, Ibrahim F.;Elweshahy, Rawan H.;Abdelrahman, Rehab S.. And the article was included in Human & Experimental Toxicology in 2021.HPLC of Formula: 42971-09-5 This article mentions the following:

Liver fibrosis is associated with increased mortality and morbidity. However, there is not effective treatment so far. Vinpocetine (Vinpo) is a synthetic derivative of vinca alkaloid vincamine. Limited previous reports have shown some beneficial effects of Vinpo in different organ fibrosis, but the ability of Vinpo to inhibit liver fibrosis induced by thioacetamide (TAA) has not been reported, that is why we investigate the potential ability of this vinca alkaloid derivative to attenuate liver fibrosis. Hepatic fibrosis was induced in male Sprague Dawley rats by TAA (200 mg/kg; i.p.; 3 times/wk) for 6 wk. Daily treatments with Vinpo (10-20 mg/kg/day; orally) ameliorated TAA-induced hepatic oxidative stress and histopathol. damage as indicated by a decrease in liver injury markers, LDH, hepatic MDA, and NOx levels, as well as increase anti-oxidative parameters. Besides, the anti-fibrotic efficacy of Vinpo was confirmed by decreasing hydroxyproline, and α-SMA. Also, the anti-inflammatory effect of Vinpo was explored by decreasing IL-6 and TNF-α levels. Our novel findings were that Vinpo decreased VEGF/Ki-67 expression in the liver confirming its effect on angiogenesis and proliferation. These findings reveal the anti-fibrotic effect of Vinpo against TAA-induced liver fibrosis in rats, and suggest the modulation of oxidative stress, inflammation, angiogenesis and proliferation as mechanistic cassette underlines this effect. In the experiment, the researchers used many compounds, for example, (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5HPLC of Formula: 42971-09-5).

(41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5) belongs to naphthyridine derivatives. The naphthyridines and their derivatives exhibit various types of biological activity, and the organic chemistry has been frequently reviewed. 1,6-Naphthyridine and some of its derivatives have been reported to have medicinal, electronic, and catalytic properties. But none of these investigations has yet resulted in any practical applications. Very few metal complexes of naphthyridines other than 1,8-naphthyridine have been described.HPLC of Formula: 42971-09-5

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss was written by Zhu, Meipeng;Liu, Hui;Sun, Kai;Liu, Jian;Mou, Yan;Qi, Dahu;Zhou, Chuankun;Abudunaibi, Maihaiti;Tasiken, Bahebieergan;Li, Jianwen;Cheng, Hao;Huang, Hui. And the article was included in Biomedicine & Pharmacotherapy in 2020.Reference of 42971-09-5 This article mentions the following:

Osteoporosis is a result of impaired bone formation and/or excessive bone resorption. Osteoclasts are the only cells in the body that have a bone resorption function. Inhibiting osteoclast activity and differentiation is a way to treat osteoporosis. The current pharmacol. treatment for osteoporosis has many shortcomings, and more effective treatments are needed. Vinpocetine (Vinp), a derivative of the alkaloid vincamine, has been used to treat cerebrovascular disorders and cognitive impairment for a long time. Vinp inhibits mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kappa B)-dependent inflammatory responses and oxidative damage in which osteoclasts are often involved. However, the effects of Vinp on the regulation of osteoclast activity remain unknown. In this study, we found that Vinp significantly inhibited receptor activator of NF-kappa B ligand (RANKL)-induced osteoclast and F-actin formation and decreased osteoclastic bone resorption in vitro. Vinp also suppressed the expression of osteoclast-specific genes, including NFATc1, c-Fos, tartrate-resistant acid phosphatase (TRAP), matrix metalloproteinase-9 (MMP-9), and cathepsin K (CTSK) at both the mRNA and protein levels. Vinp reduced activation of NF-kappa B, MAPK, and AKT signaling during osteoclastogenesis and prevented the production of reactive oxygen species with increased nuclear factor erythroid 2-related factor 2, heme oxygenase 1, and NAD(P)H:quinone acceptor oxidoreductase 1 expression. Animal experiments consistently demonstrated that Vinp treatment significantly attenuated ovariectomy-induced bone loss with a decrease in the osteoclast number and decreases in serum levels of RANKL, TRAP, interleukin-1beta, and tumor necrosis factor-alpha, as well as increased serum levels of osteoprotegerin. Taken together, our findings reveal that Vinp may be a potential pharmacol. choice for preventing and treating osteoporosis. In the experiment, the researchers used many compounds, for example, (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5Reference of 42971-09-5).

(41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5) belongs to naphthyridine derivatives. The naphthyridines have 10 delocalized π-electrons located in five molecular orbitals, each of which is distorted by the presence of the nitrogen atoms causing an electron drift in that direction. 1,6-Naphthyridine and some of its derivatives have been reported to have medicinal, electronic, and catalytic properties. But none of these investigations has yet resulted in any practical applications.Reference of 42971-09-5

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Design, Characterization, and Application of a pH-Triggered In Situ Gel for Ocular Delivery of Vinpocetine was written by Ma, Qun;Luo, Rui;Zhang, Huimin;Dai, Manman;Bai, Luyu;Fei, Qingsong;Lei, Fang;He, Ning. And the article was included in AAPS PharmSciTech in 2020.Quality Control of (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate This article mentions the following:

Abstract: We developed a pH-triggered in situ gel (ISG) for ocular delivery of vinpocetine to achieve systemic absorption and a brain-targeting effect in rats. Carbopol acted as a gelling agent combined with hydroxypropyl methylcellulose (HPMC) as a viscosity-enhancing agent. The concentration of Carbopol (0.2%, w/v) and HPMC (1.5%, w/v) was optimized for the ISG system. The optimized formulation was evaluated for studies on release in vitro, rheol., differential scanning calorimetry, ocular irritation, residence time, and in vivo pharmacokinetics. The vinpocetine ISG stayed longer in rabbit eyes than vinpocetine ointment. In vivo pharmacokinetics showed that compared with vinpocetine ointment, vinpocetine ISG attained a peak plasma concentration and area under the curve that was 1-2 folds greater in rat plasma. The Drug Targeting Index (DTI) was 1.06 and 1.26 for vinpocetine ointment and vinpocetine ISG, resp., after ocular administration, showing that vinpocetine ISG had better distribution in rat brain. These results revealed that a pH-triggered ISG system via ocular administration could be an alternative approach compared with traditional ophthalmic formulations. In the experiment, the researchers used many compounds, for example, (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5Quality Control of (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate).

(41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5) belongs to naphthyridine derivatives. The naphthyridines have 10 delocalized π-electrons located in five molecular orbitals, each of which is distorted by the presence of the nitrogen atoms causing an electron drift in that direction. 1,6-Naphthyridine and some of its derivatives have been reported to have medicinal, electronic, and catalytic properties. But none of these investigations has yet resulted in any practical applications.Quality Control of (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Metabolite profiling of fruit and seed extracts of Garcinia xanthochymus using Rp-Hplc- Esi-Q-Tof-Ms and progenesis Qi was written by Sh, Nanjegowda;Mg, Papanna;Tr, Bharathi;Rr, Raghu Ram Achar;Hs, Prakash;Sn, Swamy;P, Mallu. And the article was included in Pharma Chemica in 2018.Recommanded Product: 42971-09-5 This article mentions the following:

Natural products research is the most enormous field of research in terms of the amount of data and importance of information. Natural products discovery and metabolomics deals with a crucial mode of representation of the profile of biol. active metabolites. In this regard, the profiling of the chem. makeup of complex natural plant extracts necessarily requires employing sophisticated and advanced anal. methods like RP-HPLC-ESI-Q-TOF-MS as well as data mining and processing methods. The genus Garcinia (Clusiaceae) contains phenolic, flavonoids, xanthones, triterpenes, and benzophenones which have been reported for their significant biol. properties. Due to its high content of secondary metabolites and its large domestic usage, we have developed a simple, rapid and precise method to characterize all the secondary metabolites using Reverse-Phase Ultra Performance Liquid Chromatog. coupled to Electrospray Ionization Quadruple Time-of-Flight Mass Spectrometry (RP-HPLC-ESI-Q- TOF-MS) for the hydro-methanolic extract A total of about 3443 secondary metabolites from the fruit and 3757 secondary metabolites from the seed were identified by the Progenesis-QI data anal. Among these a total of 74 compounds from fruits and 86 polar compounds from seeds were manually identified using the mass error limit of < ± 5 ppm including the score less than 40. The unexplored bioactives belonging to the class of glycosides, flavones, xanthones, organic acids and other phenolic derivatives Garcinia xanthochymus was found to contain significant number of diverse phytochem. components. These results indicate the profile of mols. present in G. xanthochymus and will be helpful for industries and researchers involved in isolation of their mols. of interest. In the experiment, the researchers used many compounds, for example, (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5Recommanded Product: 42971-09-5).

(41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5) belongs to naphthyridine derivatives. Six naphthyridine isomers are white solids with a surprisingly wide span of melting points: 1,6-Naphthyridine’s is the lowest at <40 ºC; 2,6-naphthyridine’s is the highest at 114–115 ºC. Very few metal complexes of naphthyridines other than 1,8-naphthyridine have been described.Recommanded Product: 42971-09-5

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Effects of vinpocetine combined with batroxobin on blood glucose, hearing, and serum levels of visfatin and ENA-78 in elderly patients with type 2 diabetes mellitus and deafness was written by Wang, Jing;Zhu, Lu-ming;Yang, Bing;Li, Li;Jiang, Li-li;Le, Ting;Tu, Xiao-hong. And the article was included in Shiyong Yaowu Yu Linchuang in 2021.Recommanded Product: 42971-09-5 This article mentions the following:

Objective To investigate the effects of vinpocetine combined with batroxobin on hearing, blood glucose, and serum levels of visfatin and ENA-78 in elderly patients with type 2 diabetes mellitus and deafness. Methods A total of 94 elderly patients with type 2 diabetes mellitus with deafness receiving treatment from July 2016 to July 2019 were randomly divided into observation group and control group by random number table method, 47 cases each. All patients received hypoglycemc treatment and the basic treatment of improved cochlear microcirculation and nerve nutritional. Both groups were treated with batroxobin injection by i.v. dripping 10 BU/time, once every 2 days, for 10 days. The observation group was addnl. treated with vinpocetine by i.v. infusion, 20 mg/time, once every 2 days, for 10 days. The total effective rate, fasting blood glucose and pure tone threshold at different time points before and after treatment, serum levels of visfatin and ENA-78 before and after treatment, high-cut viscosity of whole blood, low-cut viscosity of whole blood and plasma viscosity were compared. The correlation between pure tone threshold and serum levels of visfatin and ENA-78 was analyzed. Results The total effective rate of observation group was 89.36%, which was higher than 72.34% of the control group (P<0.05). The fasting blood glucose before treatment was comparable between the two groups (P>0.05). At different time points after treatment, the fasting blood glucose of the two groups was lower than that before treatment (P<0.05), but the difference between the two groups was not statistically significant (P>0.05), and no hypoglycemia events were observed during the treatment. At different time points after treatment, the pure tone hearing threshold of the two groups was lower than that before treatment (P<0.05). The pure tone thresholds of the observation group at 8 and 10 days after treatment were (52.60±3.11) dB, (48.42±2.02) dB, which were lower than those of the control group [(55.71±3.32) dB, (52.61±2.97) dB] with statistical significance (P<0.05). After 10 days of treatment, serum visfatin and ENA-78, whole blood high-cut viscosity, whole blood low-cut viscosity and plasma viscosity of the two groups were lower than those before treatment (P<0.05), and the decrease of the observation group was even larger (P< 0.05). There was a significant pos. correlation between pure tone threshold and serum visfatin (r=0.75, P<0.001), and a pos. correlation with serum ENA-78 (r=0.72, P<0.001). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Batroxobin combined with vinpocetine can play a synergistic role in the treatment of elderly type 2 diabetes with deafness, promoting the improvement of blood rheol. and down-regulating serum visfatin, ENA-78, which promotes the recovery of hearing. Its effect is better than single batroxobin, and has higher security. In the experiment, the researchers used many compounds, for example, (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5Recommanded Product: 42971-09-5).

(41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5) belongs to naphthyridine derivatives. Six naphthyridine isomers exist, based on the positions of the nitrogen atoms; they can be in the 1,5, 1,6, 1,7, 1,8, 2,6, or 2,7 positions. 1,6-Naphthyridine and some of its derivatives have been reported to have medicinal, electronic, and catalytic properties. But none of these investigations has yet resulted in any practical applications. Very few metal complexes of naphthyridines other than 1,8-naphthyridine have been described.Recommanded Product: 42971-09-5

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Bioanalytical method for vinpocetine and apovincamine acid from human plasma by LC-MS/MS was written by Dongare, B. B.;Kashid, B. B.;Ghanvat, A. A.. And the article was included in Journal of Applicable Chemistry (Lumami, India) in 2018.HPLC of Formula: 42971-09-5 This article mentions the following:

A sensitive and reproducible liquid chromatog.-electro spray ionization-tandem mass spectrometry (LC-MS/MS) method was developed for the quantification of vinpocetine (VP) and its active metabolite apovincamine acid (AVA) in human plasma, with racem Pr vinpocetine(VP-IS) and racem Pr apovincamine acid (AVA-IS) as an internal standard (IS). The analyte was extracted with Solid Phase Extraction using ion exchange cartridges and analyzed on a Zorbax SB-CN (250 mm × 4.6 mm, 5μm) column. The mobile phase was composed of methanol 10 mM ammonium acetate with 0.1% Formic Acid (70:30). Vinpocetine, apovincamine acid and IS racem Pr vinpocetine, racem Pr apovincamine acid were ionized by pos. ion pneumatically assisted electro spray and detected in the multi-reaction monitoring (MRM) mode using LC-MS/MS (API 5500 QTrap)→ productions of m/z 351.4→280.1, m/z 323.2→279.2, m/z 365.3→294.1 and m/z 337.1→293.2 resp. The specificity, matrix effect, recovery, sensitivity, linearity, accuracy, precision, and stabilities were all validated over the concentration range of 0.5-250.0 ng mL-1 for both vinpocetine and apovincamine acid. The method developed was successfully and demonstrated for evaluation of pharmacokinetic profile of vinpocetine and apovincamine acid in human plasma. In the experiment, the researchers used many compounds, for example, (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5HPLC of Formula: 42971-09-5).

(41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5) belongs to naphthyridine derivatives. The naphthyridines have 10 delocalized π-electrons located in five molecular orbitals, each of which is distorted by the presence of the nitrogen atoms causing an electron drift in that direction. Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.HPLC of Formula: 42971-09-5

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Neuroprotective effects of novel nanosystems simultaneously loaded with vinpocetine and piracetam after intranasal administration was written by Nasr, Maha;Wahdan, Sara A.. And the article was included in Life Sciences in 2019.Synthetic Route of C22H26N2O2 This article mentions the following:

The study aim was to test the efficacy of a novel created hybrid nanosystem compared to other nanosystems in treatment of scopolamine induced memory impairment. The fabrication and characterization of nanoformulations (microemulsion, liposomes, ethosomes, transfersomes and transethosomes) coencapsulating two cognitive enhancers; piracetam and vinpocetine delivered intranasally, in addition to a novel nanocomposite microemulsion/vesicular nanoformulation was described. Formulations delivered the drugs across sheep nasal mucosa, with cumulative percentage reaching 29.99% for vinpocetine and 57.78% for piracetam. While the solution form of the drugs was totally ineffective, the selected transethosomal, microemulsion and nanocomposite formulations reversed the scopolamine induced effect on the step through latency of passive avoidance test and the spontaneous alternation behavior in Y maze test, further confirmed by histopathlogical examination All three nanoformulations significantly decreased the acetylcholinesterase activity and the extent of lipid peroxidation by 32-42%. The nanocomposite formulation was superior to the microemulsion and transethosomal formulations in its anti-inflammatory and antiapoptotic effects, delineated by higher extent of inhibition of COX-2 and caspase 3 expression resp. Results support the hypothesis that the novel microemulsion/vesicular nanocomposite system is a promising neuroprotective modality for intranasal brain targeting which is worthy of exploitation in other brain diseases. In the experiment, the researchers used many compounds, for example, (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5Synthetic Route of C22H26N2O2).

(41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5) belongs to naphthyridine derivatives. The naphthyridines have 10 delocalized π-electrons located in five molecular orbitals, each of which is distorted by the presence of the nitrogen atoms causing an electron drift in that direction. 1,6-Naphthyridine and some of its derivatives have been reported to have medicinal, electronic, and catalytic properties. But none of these investigations has yet resulted in any practical applications.Synthetic Route of C22H26N2O2

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Solubility and thermodynamic analysis of vinpocetine in various mono solvents at different temperatures was written by Ahad, Abdul;Shakeel, Faiyaz;Raish, Mohammad;Ahmad, Ajaz;Bin Jardan, Yousef A.;Al-Jenoobi, Fahad I.;Al-Mohizea, Abdullah M.. And the article was included in Journal of Thermal Analysis and Calorimetry in 2022.SDS of cas: 42971-09-5 This article mentions the following:

In the present study, the solubility of vinpocetine in ten commonly used solvents at different temperatures range of T = 298.2-323.2 K was examined and correlate the solubility data with Apelblat and Van’t Hoff models and lastly the dissolution thermodn. parameters of vinpocetine in each solvent were estimated It was observed that the vinpocetine solubility found less in water and determined to be better in non-polar solvents. Both (Apelblat and Van’t Hoff) models are found suitable to correlate the measured solubility data, still, the Van’t Hoff equation demonstrated to be more precise for the correlation of solubilities of VPN in investigated solvents. The maximum value of activity coefficients (γ2) for vinpocetine was observed in water, this could be due to low solubility of vinpocetine in water, while the value of γ2 was observed lowest in Transcutol owing to maximum solubility of vinpocetine in Transcutol. The conclusions of thermodn. parameters anal. of vinpocetine in various studied solvents brought out that the vinpocetine solubilization process was endothermic, non-spontaneous and entropy-driven. The outcomes of the present study would provide enormous support in vinpocetine solubilization, pre-formulation and dosage form development in pharmaceuticals. In the experiment, the researchers used many compounds, for example, (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5SDS of cas: 42971-09-5).

(41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5) belongs to naphthyridine derivatives. Heterocyclic nitrogen compounds, including fused 1,5-naphthyridines, have versatile applications in synthetic organic chemistry and play an important role in the field of medicinal chemistry, as many of them have a wide range of biological activities. Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.SDS of cas: 42971-09-5

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Vinpocetine restores cognitive and motor functions in Traumatic brain injury challenged rats was written by Bagri, Kajal;Deshmukh, Rahul. And the article was included in Inflammopharmacology.Name: (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate This article mentions the following:

Abstract: Traumatic brain damage is common worldwide and the treatments are not well-defined. Vinpocetine is a synthetic derivative of the vinca alkaloid vincamine and is clin. being used for various brain disorders. Here in the current study, we have investigated the neuroprotective potential of vinpocetine against traumatic brain injury. TBI was induced by the Marmarou weight drop method in rats. Brain damage was evaluated using cognitive and motor functions and the alterations in biomols. Injured rats were treated with different doses of vinpocetine (2.5, 5, and 10 mg/kg) for 4 wk. Traumatic brain injury in rats produced significant deterioration of cognition and motor functions, which was accompanied by increased oxidative stress and significant alterations in brain monoamine levels as compared with the sham control group (p < 0.05). Vinpocetine alleviated TBI-induced oxidative burden, altered neurochem., and improved the cognitive and motor functions as compared with that of the TBI control group (p < 0.05). The observed neuroprotective potential of vinpocetine may be due to the observed antioxidant potential and its ability to restore the levels of brain neurochems. under stressed conditions. The outcomes of the current study may help the repositioning of vinpocetine for preventing or treating traumatic brain injuries. In the experiment, the researchers used many compounds, for example, (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5Name: (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate).

(41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5) belongs to naphthyridine derivatives. The naphthyridine ring system, being very π-deficient, is highly vulnerable towards nucleophilic attack, and consequently there has been extensive investigation of reactions involving nitrogen nucleophiles. Transition metal complexes of 1,5-naphthyridine (1,5-napy) seems to form one-dimensional coordination polymers with the ligand acting as bidentate in a “stepped” bridging fashion.Name: (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Zero-order release and bioavailability enhancement of poorly water soluble Vinpocetine from self-nanoemulsifying osmotic pump tablet was written by El-Zahaby, Sally A.;Abou Ghaly, Mohamed H. H.;Abdelbary, Ghada A.;El-Gazayerly, Omaima N.. And the article was included in Pharmaceutical Development and Technology in 2018.SDS of cas: 42971-09-5 This article mentions the following:

Solid self-nanoemulsifying (S-SNEDDS) asym. coated osmotic tablets of the poorly water-soluble drug Vinpocetine (VNP) were designed. The aim was to control the release of VNP by the osmotic technol. taking advantage of the solubility and bioavailability-enhancing capacity of S-SNEDDS. Liquid SNEDDS loaded with 2.5 mg VNP composed of Maisine 35-1, Transcutol HP, and Cremophor EL was adsorbed on the solid carrier Aeroperl. S-SNEDDS was mixed with the osmotic tablet excipients (sodium chloride, Avicel, HPMC-K4M, PVP-K30, and Lubripharm), then directly compressed to form the core tablet. The tablets were dip coated and mech. drilled. A 32*21 full factorial design was adopted. The independent variables were: type of coating material (X1), concentration of coating solution (X2), and number of drills (X3). The dependent variables included % release at 2 h (Y1), at 4 h (Y2), and at 8 h (Y3). The in vivo performance of the optimum formula was assessed in rabbits. Zero-order VNP release was obtained by the single drilled 1.5% Opadry CA coated osmotic tablets and twofold increase in VNP bioavailability was achieved. The combination of SNEDDS and osmotic pump tablet system was successful in enhancing the solubility and absorption of VNP as well as controlling its release. In the experiment, the researchers used many compounds, for example, (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5SDS of cas: 42971-09-5).

(41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5) belongs to naphthyridine derivatives. The naphthyridines and their derivatives exhibit various types of biological activity, and the organic chemistry has been frequently reviewed. Imidazonaphthyridines have been prepared through a ‘one-pot’ three-component ‘domino’ reaction between the keto-ester, acrolein, and ethylenediamine in presence of 4 Å molecular sieves. The corresponding thiazolonaphthyridine is obtained from a similar reaction using 2-aminoethanethiol and Dowex basic anion-exchange resin.SDS of cas: 42971-09-5

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem