Tag: 208.26

Yasuda, Nobuyoshi et al. published their research in Journal of Organic Chemistry in 2004 | CAS: 204452-91-5

7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine (cas: 204452-91-5) belongs to naphthyridine derivatives. The naphthyridines and their derivatives exhibit various types of biological activity, and the organic chemistry has been frequently reviewed. Imidazonaphthyridines have been prepared through a ‘one-pot’ three-component ‘domino’ reaction between the keto-ester, acrolein, and ethylenediamine in presence of 4 Å molecular sieves. The corresponding thiazolonaphthyridine is obtained from a similar reaction using 2-aminoethanethiol and Dowex basic anion-exchange resin.Name: 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

An Efficient Synthesis of an αvβ3 Antagonist was written by Yasuda, Nobuyoshi;Hsiao, Yi;Jensen, Mark S.;Rivera, Nelo R.;Yang, Chunhua;Wells, Kenneth M.;Yau, James;Palucki, Michael;Tan, Lushi;Dormer, Peter G.;Volante, Ralph P.;Hughes, David L.;Reider, Paul J.. And the article was included in Journal of Organic Chemistry in 2004.Name: 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine This article mentions the following:

A practical preparation of an αvβ3 antagonist, (βS)-6-methoxy-β-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]-3-pyridinepropanoic acid (I), is reported. The antagonist consists of three key components, a tetrahydronaphthyridine moiety, a β-alanine moiety, and a central imidazolidone moiety. The tetrahydronaphthyridine component was prepared using two different methods, both of which relied on variations of the Friedlander reaction to establish the desired regiochem. The β-alanine component was prepared using Davies’ asym. 1,4-addition methodol. as the key stereo-defining step. The central imidazolidone portion was created from these two components using an effective three-step cyclization protocol. Thus, a highly convergent process for the drug candidate was defined. In the experiment, the researchers used many compounds, for example, 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine (cas: 204452-91-5Name: 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine).

7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine (cas: 204452-91-5) belongs to naphthyridine derivatives. The naphthyridines and their derivatives exhibit various types of biological activity, and the organic chemistry has been frequently reviewed. Imidazonaphthyridines have been prepared through a ‘one-pot’ three-component ‘domino’ reaction between the keto-ester, acrolein, and ethylenediamine in presence of 4 Å molecular sieves. The corresponding thiazolonaphthyridine is obtained from a similar reaction using 2-aminoethanethiol and Dowex basic anion-exchange resin.Name: 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Knoepfel, Thomas et al. published their research in ACS Medicinal Chemistry Letters in 2018 | CAS: 204452-91-5

7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine (cas: 204452-91-5) belongs to naphthyridine derivatives. Six naphthyridine isomers exist, based on the positions of the nitrogen atoms; they can be in the 1,5, 1,6, 1,7, 1,8, 2,6, or 2,7 positions. Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.Name: 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

2-Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4 was written by Knoepfel, Thomas;Furet, Pascal;Mah, Robert;Buschmann, Nicole;Leblanc, Catherine;Ripoche, Sebastien;Graus-Porta, Diana;Wartmann, Markus;Galuba, Inga;Fairhurst, Robin A.. And the article was included in ACS Medicinal Chemistry Letters in 2018.Name: 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine This article mentions the following:

As part of a project to identify FGFR4 selective inhibitors, scaffold morphing of a 2-formylquinoline amide hit identified series of 2-formylpyridine ureas (2-FPUs) with improved potency and physicochem. properties. In particular, tetrahydronaphthyridine urea analogs with cellular activities below 30 nM have been identified. Consistent with the hypothesized reversible-covalent mechanism of inhibition, the 2-FPUs exhibited slow binding kinetics, and the aldehyde, as the putative electrophile, could be demonstrated to be a key structural element for activity. In the experiment, the researchers used many compounds, for example, 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine (cas: 204452-91-5Name: 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine).

7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine (cas: 204452-91-5) belongs to naphthyridine derivatives. Six naphthyridine isomers exist, based on the positions of the nitrogen atoms; they can be in the 1,5, 1,6, 1,7, 1,8, 2,6, or 2,7 positions. Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.Name: 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem