Tag: 1569-16-0

1569-16-0, 2-Methyl[1,8]-Naphthyridine is a naphthyridine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 5 2-methyl-5,6,7,8-tetrahydro-1,8-naphthyridine The compound was prepared according to the procedure as described in WO 0033838. To a solution of 2-methyl-1,8-naphthyridine (2 g, 13.9 mmol) in ethanol (35 ml) was added 10percent Pd/C, and the reaction mixture was stirred under H2 (10 psi) for 24 hours. Palladium was filtered out through celite and washed with excess ethanol. The filtrate was concentrated under vacuum to give 1.7 g (83percent) pink solid. NMR (CD3OD) delta 1.82-1.87 (m, 2H), 2.22 (s, 3H), 2.65-2.76 (m, 2H), 3.33-3.36 (m, 2H), 6.32 (d,1H, J=7.25 Hz), 7.07 (d, 1H, J=7.38 Hz). Mass spectrometry: 149.15 (M+H)+.

The synthetic route of 1569-16-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pharmacia Corporation; US6921767; (2005); B2;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

1569-16-0, 2-Methyl[1,8]-Naphthyridine is a naphthyridine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of selenium dioxide (8.61 g, 77.56 mmol) in 1,4 dioxane (140 mL) with 0.5 mL ofwater was stirred at 100 ¡ãC for 5 mm. The mixture was cooled down to 0 ¡ãC and 2-Methyl-I ,8-naphthyridine (7 g, 48.5 mmol) was added dropwise. The mixture was heated again at100 ¡ãC for 5 h. Completion of the reaction was monitored by TLC. The reaction mixturewas filtered through celite bed, washed with EtOAc (50 mL) and concentrated. Theresulting crude mixture was dissolved in EtOAc (150 mL) and washed with water (3 x 60mL), brine (30 mL), dried over Na2SO4 and concentrated to give the title compound (brownsolid). 1H NMR (300 MHz, DMSO-d6): 6 10.18 (5, IH), 9.28-9.27 (m, IH), 8.74 (d, J = 8.1 Hz, IH), 8.63 (d, J= 8.1 Hz, IH), 8.11 (dd, J= 8.4, 1.2 Hz, IH), 7.83-7.79 (m, IH). LCMS:(Method B) 159.0 (M +H), Rt. 2.44 mm, 91 .59percent (Max). HPLC: (Method B) Rt 2.41 mm, 87.86percent (Max).

1569-16-0 2-Methyl[1,8]-Naphthyridine 74073, anaphthyridine compound, is more and more widely used in various.

Reference£º
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut, Gajendra; (280 pag.)WO2017/144633; (2017); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1569-16-0,2-Methyl[1,8]-Naphthyridine,as a common compound, the synthetic route is as follows.

adding 0.3 mmol of 2-methyl-1,8-naphthyridine, 0.75 mmol of elemental iodine, and 2 mL of dimethyl sulfoxide to a 15 mL pressure-resistant tube.The reaction was stirred magnetically at 110 C for 4 hours. After the reaction was cooled, 0.36 mmol of p-toluenesulfonylhydrazide and 0.9 mmol of potassium phosphate trihydrate were added, and magnetic stirring was carried out at 110 C for 6 hours. After the reaction was completed, the reaction solution was completed. Extraction, organic layer washing, drying, distillation under reduced pressure to obtain a crude product, crude product with petroleum ether / ethyl acetate = 1.5:1 ~ 2:1 (V / V) as the eluent for column separation and purification The desired product, the product is a yellow solid with a yield of 65%.

1569-16-0 2-Methyl[1,8]-Naphthyridine 74073, anaphthyridine compound, is more and more widely used in various.

Reference£º
Patent; Yantai University; Zhu Yanping; Lv Xucheng; Sun Jina; He Hangli; Sun Yuanyuan; Weng Weizhao; Wang Ru; Lv Lijuan; Huang Qiang; (17 pag.)CN110105355; (2019); A;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem