Heterocyclic Building Blocks-Naphthyridine

Comparison of RNA-seq and microarray platforms for splice event detection using a cross-platform algorithm was written by Romero, Juan P.;Ortiz-Estevez, Maria;Muniategui, Ander;Carrancio, Soraya;de Miguel, Fernando J.;Carazo, Fernando;Montuenga, Luis M.;Loos, Remco;Pio, Ruben;Trotter, Matthew W. B.;Rubio, Angel. And the article was included in BMC Genomics in 2018.Reference of 1009820-21-6 This article mentions the following:

RNA-seq is a reference technol. for determining alternative splicing at genome-wide level. Exon arrays remain widely used for the anal. of gene expression, but show poor validation rate with regard to splicing events. Com. arrays that include probes within exon junctions have been developed in order to overcome this problem. We compare the performance of RNA-seq (Illumina HiSeq) and junction arrays (Affymetrix Human Transcriptome array) for the anal. of transcript splicing events. Three different breast cancer cell lines were treated with CX-4945, a drug that severely affects splicing. To enable a direct comparison of the two platforms, we adapted EventPointer, an algorithm that detects and labels alternative splicing events using junction arrays, to work also on RNA-seq data.Common results and discrepancies between the technologies were validated and/or resolved by over 200 PCR experiments As might be expected, RNA-seq appears superior in cases where the technologies disagree and is able to discover novel splicing events beyond the limitations of phys. probe-sets. We observe a high degree of coherence between the two technologies, however, with correlation of EventPointer results over 0.90. Through decimation, the detection power of the junction arrays is equivalent to RNA-seq with up to 60 million reads. Our results suggest, therefore, that exon-junction arrays are a viable alternative to RNA-seq for detection of alternative splicing events when focusing on well-described transcriptional regions. In the experiment, the researchers used many compounds, for example, 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid (cas: 1009820-21-6Reference of 1009820-21-6).

5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid (cas: 1009820-21-6) belongs to naphthyridine derivatives. Six naphthyridine isomers exist, based on the positions of the nitrogen atoms; they can be in the 1,5, 1,6, 1,7, 1,8, 2,6, or 2,7 positions. 1,6-Naphthyridine and some of its derivatives have been reported to have medicinal, electronic, and catalytic properties. But none of these investigations has yet resulted in any practical applications. Very few metal complexes of naphthyridines other than 1,8-naphthyridine have been described.Reference of 1009820-21-6

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Synthesis of 2,6-naphthyridine was written by Giacomello, G.;Gualtieri, F.;Riceieri, F. M.;Stein, M. L.. And the article was included in Tetrahedron Letters in 1965.Name: 2,6-Naphthyridine This article mentions the following:

Transformation of 4-carbethoxynicotinic acid via the acid chloride, b_0.1 102°, gave Et β-diazoacetylisonicotinate (I), m. 58-60° (Et₂O). I treated with Ag₂O in absolute alc. with rearrangement and loss of N gave di-Et β-homocinchomeronate (II), b_0.05 116-17°; picrate m. 104-6°. II kept several days with alc. NH₄OH in a sealed tube and heated at 100° gave the diamide, converted by heating above the m.p. at 177-82° to give the imide (III), m. 229-30° (H₂O). III kept several hrs. at 120° in a sealed tube with POCl₃ gave 1,3-dichloro-2,6-naphthyridine (IV), m. 116° (petr. ether), converted to the 1,3-dihydrazine derivative, m. 300°. The dihydrazine in H₂O-AcOH heated with 10% CuSO₄ solution on a steam bath and the mixture made alk. with 5N NaOH, extracted with CH₂Cl₂ and the dried (Na₂SO₄) extract evaporated gave a solid, sublimed at 60°/0.1 mm. to yield 2,6-naphthyridine, m. 114-15°; monopicrate m. 206° (alc.). Attempted hydrogenolysis of IV with H over prereduced PtO₂ gave 5,6,7,8-tetrahydro-1,3-dichloro-2,6-naphthyridine, m. 125-7° (petr. ether). III mixed with Zn dust and heated at 170° in a sealed tube also gave 2,6-naphthyridine in poorer yields. Spectral data are given. In the experiment, the researchers used many compounds, for example, 2,6-Naphthyridine (cas: 253-50-9Name: 2,6-Naphthyridine).

2,6-Naphthyridine (cas: 253-50-9) belongs to naphthyridine derivatives. The naphthyridines and their derivatives exhibit various types of biological activity, and the organic chemistry has been frequently reviewed. Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.Name: 2,6-Naphthyridine

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Click Quantitative Mass Spectrometry Identifies PIWIL3 as a Mechanistic Target of RNA Interference Activator Enoxacin in Cancer Cells was written by Abell, Nathan S.;Mercado, Marvin;Caneque, Tatiana;Rodriguez, Raphael;Xhemalce, Blerta. And the article was included in Journal of the American Chemical Society in 2017.HPLC of Formula: 84294-96-2 This article mentions the following:

Enoxacin is a small mol. that stimulates RNA interference (RNAi) and acts as a growth inhibitor selectively in cancer but not in untransformed cells. Here, we used alkenox, a clickable enoxacin surrogate, coupled with quant. mass spectrometry, to identify PIWIL3 as a mechanistic target of enoxacin. PIWIL3 is an Argonaute protein of the PIWI subfamily that is mainly expressed in the germline and that mediates RNAi through piRNAs. Our results suggest that cancer cells re-express PIWIL3 to repress RNAi through miRNAs and thus open a new opportunity for cancer-specific targeting. In the experiment, the researchers used many compounds, for example, 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid sesquihydrate (cas: 84294-96-2HPLC of Formula: 84294-96-2).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid sesquihydrate (cas: 84294-96-2) belongs to naphthyridine derivatives. The naphthyridines have 10 delocalized π-electrons located in five molecular orbitals, each of which is distorted by the presence of the nitrogen atoms causing an electron drift in that direction. Halogen atoms attached to the naphthyridine moiety can be easily replaced by other nucleophiles such as alkoxides and amines.HPLC of Formula: 84294-96-2

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Effectiveness and safety of Ginkgo biloba, vinpocetine and piracetam as a single agent and fixed dose combination in patients with subjective tinnitus was written by Mathai, Paul;Chandran, Anu;Das, Sourav. And the article was included in Journal of Clinical and Diagnostic Research in 2021.COA of Formula: C22H26N2O2 This article mentions the following:

Owing to the lack of any standard treatment, subjective tinnitus can be debilitating, manifesting a varied population response to tinnitus management. There is, therefore, an unmet need to optimize the existing treatment options and generate data to help physicians provide the best possible care for individual patients. To compare the effectiveness and safety of Ginkgo biloba, vinpocetine, and piracetam as a single agent and their Fixed Dose Combination (FDC) in patients with subjective tinnitus. Patients with complaints of subjective tinnitus were enrolled in this longitudinal cohort, single center study which was conducted at Outpatient Clinic of the ENT Department of Justice KS Hegde Charitable Hospital, Karnataka, India. Patients received one of the five treatments, oral route, three times a day, {group 1: Ginkgo biloba (40 mg); group 2: vinpocetine (5 mg); group 3: piracetam (400 mg); group 4: FDC of Ginkgo biloba (60 mg) and piracetam (400 mg); group 5: FDC of Ginkgo biloba (60 mg), piracetam (800 mg) and vinpocetine (5 mg)} and were followed-up for six weeks using a modified version of Tinnitus Handicap Inventory (THI) and Visual Analog Scale (VAS), before and after the treatment. Data for safety were also recorded. The association between each attribute and the presence of tinnitus was assessed through chi-square tests. A total of 130 out of 149 enrolled patients completed the study. All the groups showed significant improvement in the severity of symptoms at the end of six weeks as assessed by the modified THI and VAS scores. The improvement was found to be better in group 5 than in other groups, which was evident from the percentage improvement at the end of the treatment compared to other groups. No adverse drug reactions were associated with any of the treatment groups. Though all the drugs were found to be effective and safe in reducing the intensity of subjective tinnitus, FDC of Ginkgo biloba-piracetam-vinpocetine may be considered a better alternative than Ginkgo biloba-piracetam combination and Ginkgo biloba, piracetam, or vinpocetine as single agents. In the experiment, the researchers used many compounds, for example, (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5COA of Formula: C22H26N2O2).

(41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5) belongs to naphthyridine derivatives. The naphthyridines have 10 delocalized π-electrons located in five molecular orbitals, each of which is distorted by the presence of the nitrogen atoms causing an electron drift in that direction. Halogen atoms attached to the naphthyridine moiety can be easily replaced by other nucleophiles such as alkoxides and amines.COA of Formula: C22H26N2O2

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Quantitative correlation between the electronic structure and diuretic activity of azanaphthalene derivatives was written by Singh, P.;Gupta, S. P.. And the article was included in Indian Journal of Medical Research (1913-1988) in 1979.Quality Control of 2,6-Naphthyridine This article mentions the following:

A mol. orbital PPP method was used to study the relationship between the electronic structure and the diuretic activity of azanaphthalene derivatives Regression anal. revealed significant linear correlation between the charge d. at the ring junction and the diuretic activity of the compounds In the experiment, the researchers used many compounds, for example, 2,6-Naphthyridine (cas: 253-50-9Quality Control of 2,6-Naphthyridine).

2,6-Naphthyridine (cas: 253-50-9) belongs to naphthyridine derivatives. Functionalized naphthyridines and their benzo/heterofused analogs are present in numerous marine products and reported to possess wide-ranging activities such as antiproliferative, antiaggressive, and HIV-1 integrase inhibition in addition to their use as anti-HCV agents. Transition metal complexes of 1,5-naphthyridine (1,5-napy) seems to form one-dimensional coordination polymers with the ligand acting as bidentate in a “stepped” bridging fashion.Quality Control of 2,6-Naphthyridine

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Synergistic therapeutic effect of diethylstilbestrol and CX-4945 in human acute T-lymphocytic leukemia cells was written by Jung, Jung-Il;Park, Kyeong-Yong;Kim, Soon Ae;Kim, Jiyeon. And the article was included in Biomedicine & Pharmacotherapy in 2018.Recommanded Product: 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid This article mentions the following:

Human acute T-lymphocytic leukemia (T-ALL) is one of the most commonly diagnosed hematol. disorders, and is characterized by poor prognosis and survival rate. Despite the development of new therapeutic approaches, leukemia treatment options remain limited. In this study, we investigated the immunosuppressive and anti-proliferative effects of the synthetic estrogen diethylstilbestrol (DES), both alone and combined with the casein kinase 2 (CK2) inhibitor CX-4945. Our results indicated that DES induced caspase-dependent apoptosis in a human T-ALL cell line (Jurkat cells), while exerting no significant cytotoxicity in normal peripheral blood mononuclear cells (PBMCs). Phytohaemagglutinin and phorbol 12-myristate 13-acetate induced interleukin (IL)-2 production and activation of NF-κB signaling pathways, which were both inhibited by DES. Moreover, DES exerted synergistic effects with CX-4945 on proliferation and IL-2 production in Jurkat cells. Our results demonstrated that DES exerts anti-proliferative and immunosuppressive effects through inhibition of CK2 and the NF-κB signaling pathway in human T-ALL Jurkat cells. In the experiment, the researchers used many compounds, for example, 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid (cas: 1009820-21-6Recommanded Product: 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid).

5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid (cas: 1009820-21-6) belongs to naphthyridine derivatives. Functionalized naphthyridines and their benzo/heterofused analogs are present in numerous marine products and reported to possess wide-ranging activities such as antiproliferative, antiaggressive, and HIV-1 integrase inhibition in addition to their use as anti-HCV agents. Imidazonaphthyridines have been prepared through a ‘one-pot’ three-component ‘domino’ reaction between the keto-ester, acrolein, and ethylenediamine in presence of 4 Å molecular sieves.Recommanded Product: 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

The influence of vinpocetine alone or in combination with Epigallocatechin-3-gallate, Coenzyme COQ10, Vitamin E and Selenium as a potential neuroprotective combination against aluminium-induced Alzheimer’s disease in Wistar Albino Rats was written by Ali, Azza A.;Khalil, Mona G.;Abd El-latif, Doaa M.;Okda, Tarek;Abdelaziz, Aya I.;Abu-Elfotuh, karema;Kamal, Mona M.;Wahid, Ahmed. And the article was included in Archives of Gerontology and Geriatrics in 2022.Name: (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate This article mentions the following:

Alzheimer’s disease (AD) is one of such diseases that represent the most prominent cause of dementia in elderly people. To explore the possible neuroprotective effect as well as mechanism of action of Vinpocetine either alone or in combination with EGCG, CoQ10, or VE & Se in ameliorating aluminum chloride-induced AD in rats. Rats were received AlCl₃ (70 mg/kg) i.p. daily dose for 30 days along with EGCG (10 mg/kg, I.P), CoQ10 (200 mg/kg, P.O), VE (100 mg/kg, P.O) & Se (1 mg/kg, P.O) as well as Vinpocetine (20 mg/kg, P.O) either alone or in combination. Results revealed that the combination of Vinpocetine with EGCG showed the best neuroprotection. This protection in the brain was indicated by the significant decrease in Aβ and ACHE. The same pattern of results were shown in the levels of monoamines and BDNF. In addition, the combination of Vinpocetine with EGCG showed more pronounced anti-inflammatory (TNF-α, IL-1β) and antioxidant (MDA, SOD, TAC) effects in comparison to other combinations. These results were confirmed using histopathol. examinations as well as DNA fragmentation assays. Vinpocetine with EGCG showed pronounced protection on neurons against AD induced by AlCl₃ in rats. In the experiment, the researchers used many compounds, for example, (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5Name: (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate).

(41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5) belongs to naphthyridine derivatives. The naphthyridine ring system, being very π-deficient, is highly vulnerable towards nucleophilic attack, and consequently there has been extensive investigation of reactions involving nitrogen nucleophiles. Imidazonaphthyridines have been prepared through a ‘one-pot’ three-component ‘domino’ reaction between the keto-ester, acrolein, and ethylenediamine in presence of 4 Å molecular sieves. The corresponding thiazolonaphthyridine is obtained from a similar reaction using 2-aminoethanethiol and Dowex basic anion-exchange resin.Name: (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

PSNAP: Proteome-wide analysis of elongating nascent polypeptide chains was written by Uchiyama, Junki;Roy, Rohini;Wang, Dan Ohtan;Morikawa, Kazuya;Kawahara, Yuka;Iwasaki, Mio;Yoshino, Chiaki;Mishima, Yuichiro;Ishihama, Yasushi;Imami, Koshi. And the article was included in iScience in 2022.Recommanded Product: 1009820-21-6 This article mentions the following:

Cellular global translation is often measured using ribosome profiling or quant. mass spectrometry, but these methods do not provide direct information at the level of elongating nascent polypeptide chains (NPCs) and associated co-translational events. Here, we describe pSNAP, a method for proteome-wide profiling of NPCs by affinity enrichment of puromycin- and stable isotope-labeled polypeptides. pSNAP does not require ribosome purification and/or chem. labeling, and captures bona fide NPCs that characteristically exhibit protein N-terminus-biased positions. We applied pSNAP to evaluate the effect of silmitasertib, a potential mol. therapy for cancer, and revealed acute translational repression through casein kinase II and mTOR pathways. We also characterized modifications on NPCs and demonstrated that the combination of different types of modifications, such as acetylation and phosphorylation in the N-terminal region of histone H1.5, can modulate interactions with ribosome-associated factors. Thus, pSNAP provides a framework for dissecting co-translational regulations on a proteome-wide scale. In the experiment, the researchers used many compounds, for example, 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid (cas: 1009820-21-6Recommanded Product: 1009820-21-6).

5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid (cas: 1009820-21-6) belongs to naphthyridine derivatives. Six naphthyridine isomers exist, based on the positions of the nitrogen atoms; they can be in the 1,5, 1,6, 1,7, 1,8, 2,6, or 2,7 positions. Transition metal complexes of 1,5-naphthyridine (1,5-napy) seems to form one-dimensional coordination polymers with the ligand acting as bidentate in a “stepped” bridging fashion.Recommanded Product: 1009820-21-6

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Protein kinase CK2 impact on intracellular calcium homeostasis in prostate cancer was written by Afzal, Muhammad;Kren, Betsy T.;Naveed, A. Khaliq;Trembley, Janeen H.;Ahmed, Khalil. And the article was included in Molecular and Cellular Biochemistry in 2020.Quality Control of 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid This article mentions the following:

Abstract: Protein kinase CK2 plays multiple roles in cell function in normal and disease states. CK2 is elevated in numerous types of cancer cells, and CK2 suppression of apoptosis represents a key link to the cancer cell phenotype. CK2 regulation of cell survival and death involves diverse processes, and our previous work suggested that mitochondrial machinery is a key locus of this function. One of the earliest responses of prostate cells to inhibition of CK2 is a change in mitochondrial membrane potential, possibly associated with Ca²⁺ signaling. PCa cells were treated with the CK2 small mol. inhibitors 4,5,6,7-tetrabrombenzotriazole and CX-4945 followed by anal. of Ca²⁺ levels in various cellular compartments over time. The results showed dose-dependent loss in cytosolic Ca²⁺ levels starting within 2 min and reaching maximal loss within 5-10 min. The results suggest that inhibition of CK2 activity results in a rapid movement of Ca²⁺ out of the cytosol and into the ER and mitochondria, which may be among the earliest contributory factors for induction of apoptosis in cells subjected to inhibition of CK2. In cells with death-inducing levels of CK2 inhibition, total cellular Ca²⁺ levels dropped at 2 h post-treatment. These novel observations represent a potential mechanism underlying regulation of cell survival and death by CK2 activity. In the experiment, the researchers used many compounds, for example, 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid (cas: 1009820-21-6Quality Control of 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid).

5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid (cas: 1009820-21-6) belongs to naphthyridine derivatives. The naphthyridines have 10 delocalized π-electrons located in five molecular orbitals, each of which is distorted by the presence of the nitrogen atoms causing an electron drift in that direction. Halogen atoms attached to the naphthyridine moiety can be easily replaced by other nucleophiles such as alkoxides and amines.Quality Control of 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Protonated polycyclic aromatic nitrogen heterocyclics: Proton affinities, polarizabilities, and atomic and ring charges of 1-5-ring ions was written by Maclagan, Robert G. A. R.;Gronert, Scott;Meot-Ner, Michael. And the article was included in Journal of Physical Chemistry A in 2015.Electric Literature of C8H6N2 This article mentions the following:

Calculated proton affinities, polarizabilities, and some ionization energies and at. and ring NBO charges are reported for 31 polycyclic aromatic nitrogen heterocyclics (PANHs) with 1-5 rings, calculated on the on the M06-2X/6-311+g**//B3LYP/6-31g* level of theory. The calculated proton affinities from 226 to 241 kcal mol^-1 for 3-5-ring compounds, predict well the relative exptl. values. The proton affinities increase with increasing mol. size and show a linear correlation with polarizabilities. Linear geometry and nitrogen located in the central ring also favor increased proton affinity. These trends estimate a PA > 241 kcal mol^-1 for an infinite linear chain, end-ring-N PANH mol., and >261 kcal mol^-1 for an edge-N-doped graphene sheet, making it a superbase. NBO anal. shows that from pyridineH⁺ to large 5-ring ions, the N-H nitrogen carries a constant q(N) = -0.46 ± 0.1 charge, and the N-H hydrogen a constant q(H) = 0.43 ± 0.01 pos. charge, similar to the q(H) in NH₄⁺. Overall, the NH group is nearly elec. neutral, and a nearly full pos. charge is distributed on the aromatic hydrocarbon rings of the ions. When the nitrogen is in a central ring, that ring is neg., and the pos. ionic charge is delocalized toward the end rings. When the nitrogen is in an end ring, the ionic charge is distributed more evenly. Increasing proton affinities with increasing polarizability result not from increasing charge transfer from the proton to the aromatic rings, but from increasing delocalization of the transferred charge in the aromatic hydrocarbon rings of the ions. In two-nitrogen compounds, interactions between the ring nitrogens decrease the proton affinities, but this effect decreases in larger ions. In the experiment, the researchers used many compounds, for example, 2,6-Naphthyridine (cas: 253-50-9Electric Literature of C8H6N2).

2,6-Naphthyridine (cas: 253-50-9) belongs to naphthyridine derivatives. The naphthyridines and their derivatives exhibit various types of biological activity, and the organic chemistry has been frequently reviewed. Imidazonaphthyridines have been prepared through a ‘one-pot’ three-component ‘domino’ reaction between the keto-ester, acrolein, and ethylenediamine in presence of 4 Å molecular sieves.Electric Literature of C8H6N2

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem