Category: 959558-28-2

4-Bromo-2,7-naphthyridin-1-amine, cas is 959558-28-2, it is a common heterocyclic compound, the naphthyridine compound, its synthesis route is as follows.,959558-28-2

A solution of Bromo compound 6a (100 mg, 0.45 mmol, 1.2 equiv), Pd(PPh3)4 (10 mol%), CuI (5 mol%) and Triphenylphosphine (10 mg) in Triethylamine (1.5 mL) was de-oxygenated using steam of Argon gas. A de-oxygenated solution of alkyne 2b (150 mg, 0.37 mmol, 1 equiv) in DMF (4 mL) was added slowly over a period of 10 min to the solution and the reaction temperature was increased to 55 C and allowed to stir 12 h. The reaction was diluted with ethyl acetate (300 mL). The organic layer was washed with water (5 ¡Á 50 mL), saturated NH4Cl (1 ¡Á 50 mL) and washed with brine (1 ¡Á 50 mL). Combined organic layers were dried over anhydrous sodium sulphate, filtered and concentrated in vacuo. The pure product 16 was obtained by flash column chromatography. Yield = 35%; TLC Rf = 0.1 (10 % MeOH/CH2Cl2) 1H NMR (500 MHz, DMSO-d6) delta 10.77 (s, 1H), 9.60 (s, 1H), 9.05 (d, J = 2.2 Hz, 1H), 9.00 (d, J = 2.0 Hz, 1H), 8.73 (d, J = 5.7 Hz, 1H), 8.54 (t, J = 2.1 Hz, 1H), 8.38 (s, 1H), 8.20 (s, 1H), 8.04 (d, J = 9.9 Hz, 1H), 7.96 (d, J = 5.7 Hz, 1H), 7.93 (s, 2H), 7.73 (s, 1H), 3.57 (s, 2H), 2.39 (s, 8H), 2.17 (s, 3H); 13C NMR (126 MHz, DMSO) delta 164.06, 158.62, 154.11, 152.24, 149.60, 148.90, 148.03, 140.47, 138.31, 137.37, 132.96, 131.83, 130.34, 128.86, 124.01, 120.21, 117.56, 112.05, 100.80, 90.37, 89.95, 57.87, 55.11, 53.02, 46.03; HRMS (ESI+): calcd. for C29H27F3N7O (MH+) 546.2224, found 546.2221

959558-28-2 is used more and more widely, we look forward to future research findings about 4-Bromo-2,7-naphthyridin-1-amine

Reference£º
Article; Wang, Modi; Naganna; Sintim, Herman O.; Bioorganic Chemistry; vol. 90; (2019);,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

It is a common heterocyclic compound, the naphthyridine compound, 4-Bromo-2,7-naphthyridin-1-amine, cas is 959558-28-2 its synthesis route is as follows.,959558-28-2

A solution of Bromo compound 6a (96 mg, 0.43 mmol, 1.2 equiv), Pd(PPh3)4 (10 mol%), CuI (5 mol%) and Triphenylphosphine (10 mg) in Triethylamine (1.5 mL, 10.8 mmol, 30 equiv) was de-oxygenated using steam of Argon gas. A de-oxygenated solution of alkyne 3b (150 mg, 0.36 mmol, 1 equiv) in DMF (4 mL) was added slowly over a period of 10 min to the solution and the reaction temperature was increased to 50 C and allowed to stir 12 h. The reaction was quenched by addition of NH4Cl (5 mL) at room temperature and diluted with ethyl acetate (300 mL). The organic layer was washed with water (5 ¡Á 50 mL) and washed with brine (1 ¡Á 50 mL). Combined organic layers were dried over anhydrous sodium sulphate, filtered and concentrated in vacuo. The pure product 15 was obtained by flash column chromatography. Yield = 49%.; TLC Rf = 0.1 (10 % MeOH/CH2Cl2). 1H NMR (500 MHz, DMSO-d6) delta 10.65 (s, 1H), 9.60 (s, 1H), 8.93 (s, 1H), 8.74 (d, J = 5.7 Hz, 1H), 8.48 (s, 1H), 8.39 (s, 1H), 8.18 (s, 1H), 8.03 (d, J = 8.5 Hz, 1H), 7.92 (s, 2H), 7.88 (d, J = 5.7 Hz, 1H), 7.70 (d, J = 8.5 Hz, 1H), 3.55 (s, 2H), 2.80 (s, 3H), 2.37 (s, 8H), 2.14 (s, 3H); 13C NMR (126 MHz, DMSO) delta 164.01, 162.28, 158.58, 152.20, 149.63, 148.92, 147.44, 140.37, 138.34, 137.81, 132.86, 131.74, 127.93, 127.77, 123.97, 118.86, 117.71, 117.37, 112.05, 101.07, 92.66, 90.47, 57.90, 55.19, 53.17, 46.19, 24.28; HRMS (ESI+): calcd. for C30H29F3N7O (MH+) 560.2380, found 560.2380

With the complex challenges of chemical substances, we look forward to future research findings about 4-Bromo-2,7-naphthyridin-1-amine

Reference£º
Article; Wang, Modi; Naganna; Sintim, Herman O.; Bioorganic Chemistry; vol. 90; (2019);,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

959558-28-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4-Bromo-2,7-naphthyridin-1-amine, cas is 959558-28-2,the naphthyridine compound, it is a common compound, a new synthetic route is introduced below.

A solution of Bromo compound 6a (96 mg, 0.43 mmol, 1.2 equiv), Pd(PPh3)4 (10 mol%), CuI (5 mol%) and Triphenylphosphine (10 mg) in Triethylamine (1.5 mL, 10.8 mmol, 30 equiv) was de-oxygenated using steam of Argon gas. A de-oxygenated solution of alkyne 3b (150 mg, 0.36 mmol, 1 equiv) in DMF (4 mL) was added slowly over a period of 10 min to the solution and the reaction temperature was increased to 50 C and allowed to stir 12 h. The reaction was quenched by addition of NH4Cl (5 mL) at room temperature and diluted with ethyl acetate (300 mL). The organic layer was washed with water (5 ¡Á 50 mL) and washed with brine (1 ¡Á 50 mL). Combined organic layers were dried over anhydrous sodium sulphate, filtered and concentrated in vacuo. The pure product 15 was obtained by flash column chromatography. Yield = 49%.; TLC Rf = 0.1 (10 % MeOH/CH2Cl2). 1H NMR (500 MHz, DMSO-d6) delta 10.65 (s, 1H), 9.60 (s, 1H), 8.93 (s, 1H), 8.74 (d, J = 5.7 Hz, 1H), 8.48 (s, 1H), 8.39 (s, 1H), 8.18 (s, 1H), 8.03 (d, J = 8.5 Hz, 1H), 7.92 (s, 2H), 7.88 (d, J = 5.7 Hz, 1H), 7.70 (d, J = 8.5 Hz, 1H), 3.55 (s, 2H), 2.80 (s, 3H), 2.37 (s, 8H), 2.14 (s, 3H); 13C NMR (126 MHz, DMSO) delta 164.01, 162.28, 158.58, 152.20, 149.63, 148.92, 147.44, 140.37, 138.34, 137.81, 132.86, 131.74, 127.93, 127.77, 123.97, 118.86, 117.71, 117.37, 112.05, 101.07, 92.66, 90.47, 57.90, 55.19, 53.17, 46.19, 24.28; HRMS (ESI+): calcd. for C30H29F3N7O (MH+) 560.2380, found 560.2380

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 959558-28-2, 4-Bromo-2,7-naphthyridin-1-amine

Reference£º
Article; Wang, Modi; Naganna; Sintim, Herman O.; Bioorganic Chemistry; vol. 90; (2019);,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

As a common heterocyclic compound, it belong naphthyridine compound,4-Bromo-2,7-naphthyridin-1-amine,959558-28-2,Molecular formula: C8H6BrN3,mainly used in chemical industry, its synthesis route is as follows.,959558-28-2

4-(1-Benzenesulfonyl-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,7-naphthyridin-1-ylamine23.7 g of tripotassium phosphate and 3.2 g of trans-dichlorobis(tricyclohexyl-phosphine)palladium(II) are added to a solution of 12.5 g of 4-bromo-2,7-naphthyridin-1-ylamine in 400 ml of diglyme and 15 ml of water. The mixture is heated to 125, and 25 g of 1-(benzenesulfonyl)-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine in 100 ml of diglyme are added dropwise over the course of 30 minutes. The mixture is stirred at 125 for 3 h, at room temperature for 20 h and the solvent is subsequently removed and the mixture is subjected to conventional work-up. The product is purified by means of flash chromatography over 330 g of silica with a methanol gradient in ethyl acetate with 200 ml/min with UV detection at 254 nm, giving a pure fraction (5.1 g) and a contaminated fraction (6.5 g) of 4-(1-benzenesulfonyl-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,7-naphthyridin-1-ylamine, M415.47 g/mol, M+H found 416.

With the synthetic route has been constantly updated, we look forward to future research findings about 4-Bromo-2,7-naphthyridin-1-amine,belong naphthyridine compound

Reference£º
Patent; Merck Patent GmbH; Jonczyk, Alfred; Zenke, Frank T.; Amendt, Christiane; US2015/252041; (2015); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

4-Bromo-2,7-naphthyridin-1-amine, cas is 959558-28-2, it is a common heterocyclic compound, the naphthyridine compound, its synthesis route is as follows.

959558-28-2, EXAMPLE 32: Synthesis of 4-[2-(2-fluoro-phenyl)-[1 ,8]naphthyridin-4-yl]-[2,7]naphthyridin- 1- C/MS: 1.40, [M+H] 368

With the rapid development of chemical substances, we look forward to future research findings about 4-Bromo-2,7-naphthyridin-1-amine

Reference£º
Patent; MERCK PATENT GMBH; JONCZYK, Alfred; DORSCH, Dieter; HOELZEMANN, Guenter; AMENDT, Christiane; ZENKE, Frank; WO2011/95196; (2011); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

959558-28-2, 4-Bromo-2,7-naphthyridin-1-amine is a naphthyridine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,959558-28-2

A solution of Bromo compound 6a (96 mg, 0.43 mmol, 1.2 equiv), Pd(PPh3)4 (10 mol%), CuI (5 mol%) and Triphenylphosphine (10 mg) in Triethylamine (1.5 mL, 10.8 mmol, 30 equiv) was de-oxygenated using steam of Argon gas. A de-oxygenated solution of alkyne 3b (150 mg, 0.36 mmol, 1 equiv) in DMF (4 mL) was added slowly over a period of 10 min to the solution and the reaction temperature was increased to 50 C and allowed to stir 12 h. The reaction was quenched by addition of NH4Cl (5 mL) at room temperature and diluted with ethyl acetate (300 mL). The organic layer was washed with water (5 ¡Á 50 mL) and washed with brine (1 ¡Á 50 mL). Combined organic layers were dried over anhydrous sodium sulphate, filtered and concentrated in vacuo. The pure product 15 was obtained by flash column chromatography. Yield = 49%.; TLC Rf = 0.1 (10 % MeOH/CH2Cl2). 1H NMR (500 MHz, DMSO-d6) delta 10.65 (s, 1H), 9.60 (s, 1H), 8.93 (s, 1H), 8.74 (d, J = 5.7 Hz, 1H), 8.48 (s, 1H), 8.39 (s, 1H), 8.18 (s, 1H), 8.03 (d, J = 8.5 Hz, 1H), 7.92 (s, 2H), 7.88 (d, J = 5.7 Hz, 1H), 7.70 (d, J = 8.5 Hz, 1H), 3.55 (s, 2H), 2.80 (s, 3H), 2.37 (s, 8H), 2.14 (s, 3H); 13C NMR (126 MHz, DMSO) delta 164.01, 162.28, 158.58, 152.20, 149.63, 148.92, 147.44, 140.37, 138.34, 137.81, 132.86, 131.74, 127.93, 127.77, 123.97, 118.86, 117.71, 117.37, 112.05, 101.07, 92.66, 90.47, 57.90, 55.19, 53.17, 46.19, 24.28; HRMS (ESI+): calcd. for C30H29F3N7O (MH+) 560.2380, found 560.2380

As the paragraph descriping shows that 959558-28-2 is playing an increasingly important role.

Reference£º
Article; Wang, Modi; Naganna; Sintim, Herman O.; Bioorganic Chemistry; vol. 90; (2019);,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.959558-28-2,4-Bromo-2,7-naphthyridin-1-amine,as a common compound, the synthetic route is as follows.,959558-28-2

A solution of Bromo compound 6a (100 mg, 0.45 mmol, 1.2 equiv), Pd(PPh3)4 (10 mol%), CuI (5 mol%) and Triphenylphosphine (10 mg) in Triethylamine (1.5 mL) was de-oxygenated using steam of Argon gas. A de-oxygenated solution of alkyne 2b (150 mg, 0.37 mmol, 1 equiv) in DMF (4 mL) was added slowly over a period of 10 min to the solution and the reaction temperature was increased to 55 C and allowed to stir 12 h. The reaction was diluted with ethyl acetate (300 mL). The organic layer was washed with water (5 ¡Á 50 mL), saturated NH4Cl (1 ¡Á 50 mL) and washed with brine (1 ¡Á 50 mL). Combined organic layers were dried over anhydrous sodium sulphate, filtered and concentrated in vacuo. The pure product 16 was obtained by flash column chromatography. Yield = 35%; TLC Rf = 0.1 (10 % MeOH/CH2Cl2) 1H NMR (500 MHz, DMSO-d6) delta 10.77 (s, 1H), 9.60 (s, 1H), 9.05 (d, J = 2.2 Hz, 1H), 9.00 (d, J = 2.0 Hz, 1H), 8.73 (d, J = 5.7 Hz, 1H), 8.54 (t, J = 2.1 Hz, 1H), 8.38 (s, 1H), 8.20 (s, 1H), 8.04 (d, J = 9.9 Hz, 1H), 7.96 (d, J = 5.7 Hz, 1H), 7.93 (s, 2H), 7.73 (s, 1H), 3.57 (s, 2H), 2.39 (s, 8H), 2.17 (s, 3H); 13C NMR (126 MHz, DMSO) delta 164.06, 158.62, 154.11, 152.24, 149.60, 148.90, 148.03, 140.47, 138.31, 137.37, 132.96, 131.83, 130.34, 128.86, 124.01, 120.21, 117.56, 112.05, 100.80, 90.37, 89.95, 57.87, 55.11, 53.02, 46.03; HRMS (ESI+): calcd. for C29H27F3N7O (MH+) 546.2224, found 546.2221

959558-28-2 4-Bromo-2,7-naphthyridin-1-amine 23727075, anaphthyridine compound, is more and more widely used in various fields.

Reference£º
Article; Wang, Modi; Naganna; Sintim, Herman O.; Bioorganic Chemistry; vol. 90; (2019);,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

959558-28-2,959558-28-2, 4-Bromo-2,7-naphthyridin-1-amine is a naphthyridine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 32: Synthesis of 4-[2-(2-fluoro-phenyl)-[1 ,8]naphthyridin-4-yl]-[2,7]naphthyridin- 1- C/MS: 1.40, [M+H] 368

959558-28-2 4-Bromo-2,7-naphthyridin-1-amine 23727075, anaphthyridine compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK PATENT GMBH; JONCZYK, Alfred; DORSCH, Dieter; HOELZEMANN, Guenter; AMENDT, Christiane; ZENKE, Frank; WO2011/95196; (2011); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

959558-28-2, 4-Bromo-2,7-naphthyridin-1-amine is a naphthyridine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-(1-Benzenesulfonyl-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,7-naphthyridin-1-ylamine23.7 g of tripotassium phosphate and 3.2 g of trans-dichlorobis(tricyclohexyl-phosphine)palladium(II) are added to a solution of 12.5 g of 4-bromo-2,7-naphthyridin-1-ylamine in 400 ml of diglyme and 15 ml of water. The mixture is heated to 125, and 25 g of 1-(benzenesulfonyl)-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine in 100 ml of diglyme are added dropwise over the course of 30 minutes. The mixture is stirred at 125 for 3 h, at room temperature for 20 h and the solvent is subsequently removed and the mixture is subjected to conventional work-up. The product is purified by means of flash chromatography over 330 g of silica with a methanol gradient in ethyl acetate with 200 ml/min with UV detection at 254 nm, giving a pure fraction (5.1 g) and a contaminated fraction (6.5 g) of 4-(1-benzenesulfonyl-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,7-naphthyridin-1-ylamine, M415.47 g/mol, M+H found 416., 959558-28-2

The synthetic route of 959558-28-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Merck Patent GmbH; Jonczyk, Alfred; Zenke, Frank T.; Amendt, Christiane; US2015/252041; (2015); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem