On November 22, 2007, Shishido, Yuji; Nakao, Kazunari; Nagayama, Satoshi; Tanaka, Hirotaka; Duncton, Matthew Alexander James; Cox, Matthew; Kincaid, John; Sahasrabudhe, Kiran; Estiarte-Martinez, Maria de Los Angeles published a patent.Recommanded Product: 958334-24-2 The title of the patent was Preparation of bicyclic amide derivatives as ion-channel ligands. And the patent contained the following:
The title compounds I [W, W1, X1, X1, Y, Y1, Z = CR8 or N; R1, R2 = H, halo, OH, etc.; R3 = H, halo, OH, etc.; R4, R5 = H, alkyl, halo, haloalkyl, hydroxyalkyl; R7 = alkyl; R8 = H, halo, OH, etc.] that may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of nonlimiting example, pain, inflammation, traumatic injury, and others, were prepared and formulated. A multistep synthesis of (1R)-II, starting from 1-(4-hydroxy-3-methylphenyl)ethanone, is described. Exemplified compounds I were evaluated in an acid stimulation assay (IC50 values of VR1 antagonists were given). The experimental process involved the reaction of Methyl 7-bromo-1,5-naphthyridine-3-carboxylate(cas: 958334-24-2).Recommanded Product: 958334-24-2
The Article related to bicyclic amide preparation ion channel ligand vr1 antagonist, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Recommanded Product: 958334-24-2
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem