Category: 76629-10-2

On February 29, 2000, Nishijima, Kazumi; Nishida, Hidemitsu; Yamashita, Yoshiaki; Ito, Manabu; Onuki, Yoshiaki; Mizota, Masahiro; Miyano, Sotaro published an article.Electric Literature of 76629-10-2 The title of the article was Synthesis and diuretic activity of bicyclic fused heterocycles containing oxime-O-sulfonic acid moiety. And the article contained the following:

In order to investigate the origin of the loop-type diuretic activity of M17055, several variants were designed and synthesized by modifying the quinolinone skeleton, and their diuretic activities were compared with the lead M17055 and furosemide in dogs. It was found that the neg. charge distribution pattern afforded by the dispositional arrangement of the 4-oxime-O-sulfonic acid and 1-N-acyl carbonyl moiety attached to the tetrahydropyridine ring system is inevitable for the development of the activity, which strongly supports the previously proposed model for the active site of the Na+-K+-2Cl- cotransporter. The experimental process involved the reaction of 7-Chloro-2,3-dihydro-1,8-naphthyridin-4(1H)-one(cas: 76629-10-2).Electric Literature of 76629-10-2

The Article related to oxime sulfonate heterocycle preparation diuretic structure, Pharmacology: Structure-Activity and other aspects.Electric Literature of 76629-10-2

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

On October 27, 2016, Asano, Yasutomi; Kojima, Takuto; Kurasawa, Osamu; Wong, Tzu-Tshin; Hirata, Yasuhiro; Iwamura, Naoki; Saito, Bunnai; Tanaka, Yuta; Arai, Ryosuke; Imamura, Shinichi; Yonemori, Kazuko; Miyamoto, Yasufumi; Kitamura, Shuji; Sano, Osamu published a patent.Recommanded Product: 7-Chloro-2,3-dihydro-1,8-naphthyridin-4(1H)-one The title of the patent was Preparation of 1-acyl-4-acylaminopiperidine derivatives as serine palmitoyltransferase (SPT) inhibitors. And the patent contained the following:

The present invention relates to the title compounds I [ring Ar = each (un)substituted aromatic heterocyclyl or C6-14 aromatic hydrocarbyl; ring A = each (un)substituted C6-14 aromatic hydrocarbyl or heterocyclyl; R1 = each (un)substituted C6-14 aryl, C3-10 cycloalkyl, or heterocyclyl; when R1 is (un)substituted heterocyclyl, R1 = Q or Q1; ring B = (un)substituted heterocyclyl; ring D = (un)substituted N-containing heterocyclyl; R2 = H or R1 and R2 are bonded together to form (un)substituted 5- or 6-membered aromatic heterocyclyl or (un)substituted benzene ring] or salts thereof. These compounds are serine palmitoyltransferase (SPT) inhibitors and potentially useful for treating or preventing SPT-related disease including congenital disease accompanied by sphingolipid accumulation, cancer, and Niemann-Pick disease in mammals. Thus, 188 mg 2-chlorobenzoyl chloride was gradually added to a solution of 283 mg (7-amino-2-methyl-2,5,6,7-tetrahydro-4H-pyrazolo[4,3-b]pyridin-4-yl)(3,4-dimethoxyphenyl)methanone and 270 mg Et3N in 5 mL CH2Cl2 under ice-cooling and the resulting mixture was stirred at room temperature for 1 h to give, after workup and silica gel chromatog., 2-chloro-N-(4-(3,4-dimethoxybenzoyl)-2-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-b]pyridin-7-yl)benzamide (II). II at 1 μM inhibited 91% human serine palmitoyltransferase (SPT). A capsule and a tablet formulation containing II were described. The experimental process involved the reaction of 7-Chloro-2,3-dihydro-1,8-naphthyridin-4(1H)-one(cas: 76629-10-2).Recommanded Product: 7-Chloro-2,3-dihydro-1,8-naphthyridin-4(1H)-one

The Article related to acylaminoacylpiperidine preparation serine palmitoyltransferase spt inhibitor, pyrazolopyridinylbenzamide preparation serine palmitoyltransferase spt inhibitor, congenital disease sphingolipid accumulation treatment prevention acylaminoacylpiperidine preparation, cancer niemann pick disease treatment prevention acylaminoacylpiperidine preparation and other aspects.Recommanded Product: 7-Chloro-2,3-dihydro-1,8-naphthyridin-4(1H)-one

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

On August 31, 1990, Ferrarini, P. L.; Mori, C.; Primofiore, G.; Da Settimo, A.; Breschi, M. C.; Martinotti, E.; Nieri, P.; Ciucci, M. A. published an article.Related Products of 76629-10-2 The title of the article was Synthesis and β-blocking activity of (E)- and (Z)-iminoethers of 1,8-naphthyridine. Potential antihypertensive agents. 4. And the article contained the following:

A series of (E)- (I, R = Br, Cl, Me, OMe or OEt, R1 = H or Br; R2 = iso-Pr, tert-Bu) and (Z)-imino ethers (II, R = Br, Cl, Me, OMe or OEt and R2 = iso-Pr or tert-Bu) of 1,8-naphthyridine were prepared from the corresponding ketones by a series of reactions involving oxime formation, reaction with epichlorohydrin followed by reaction with amines. The pharmacol. activities of these compounds were evaluated by using isolated guinea pig atria or trachea, or rat vas deferens. All compounds showed β2 adrenergic agonist and B1-blocking properties. Neither stimulation nor blocking activity was observed on α receptors. The activity was independent of the side-chain and no difference was observed in activity between (E)-I or (Z)-II. The experimental process involved the reaction of 7-Chloro-2,3-dihydro-1,8-naphthyridin-4(1H)-one(cas: 76629-10-2).Related Products of 76629-10-2

The Article related to beta blocker naphthyridine imino ether preparation, adrenergic agonist naphthyridine imino ether preparation, naphthyridine imino ether adrenergic agonist antagonist, antihypertensive naphthyridine imino ether and other aspects.Related Products of 76629-10-2

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Da Settimo, Antonio; Biagi, Giuliana; Primofiore, Giampaolo; Ferrarini, Pier Luigi; Livi, Oreste; Marini, Anna Maria published an article in 1980, the title of the article was Synthesis of some 3,7-disubstituted quino[3,2-c][1,8]naphthyridines.Application In Synthesis of 7-Chloro-2,3-dihydro-1,8-naphthyridin-4(1H)-one And the article contains the following content:

Quinonaphthyridines I (R = Me, Br, Cl, EtO, NH2; R1 = Me, Et; R2 = R3 = H) were prepared in 13-95% yields by cyclizing II with o-H2NC6H4COR1. Heating I (R2 = R3 = H) in PhNO2 gave I (R2R3 = bond). The experimental process involved the reaction of 7-Chloro-2,3-dihydro-1,8-naphthyridin-4(1H)-one(cas: 76629-10-2).Application In Synthesis of 7-Chloro-2,3-dihydro-1,8-naphthyridin-4(1H)-one

The Article related to quinonaphthyridine, naphthyridinone phenone cyclization, acetophenone naphthyridinone cyclization, benzophenone naphthyridinone cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application In Synthesis of 7-Chloro-2,3-dihydro-1,8-naphthyridin-4(1H)-one

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

On August 31, 1981, Ferrarini, Pier Luigi; Biagi, Giuliana; Livi, Oreste; Primofiore, Giampaolo; Carpene, Marino published an article.Quality Control of 7-Chloro-2,3-dihydro-1,8-naphthyridin-4(1H)-one The title of the article was Synthesis of some 3-substituted [1,8]Naphthyrido[3,2-c][1,8]naphthyridines. A new heterocyclic ring system. And the article contained the following:

The title compounds (I; R = Me, Br, Cl, EtO, HS) were prepared by condensation of naphthyridinones (II) with 2-aminonicotinaldehyde. I were transformed into the fully aromatic compounds by refluxing with nitrobenzene. The experimental process involved the reaction of 7-Chloro-2,3-dihydro-1,8-naphthyridin-4(1H)-one(cas: 76629-10-2).Quality Control of 7-Chloro-2,3-dihydro-1,8-naphthyridin-4(1H)-one

The Article related to naphthyridonaphthyridine, condensation naphthyridinone aminonicotinaldehyde, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Quality Control of 7-Chloro-2,3-dihydro-1,8-naphthyridin-4(1H)-one

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem