Category: 72754-05-3

72754-05-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6-Bromo-1,8-naphthyridin-2-ol, cas is 72754-05-3,the naphthyridine compound, it is a common compound, a new synthetic route is introduced below.

c) (EVtert-butyl 3-(7-oxo-7.8-dihvdro-l ,,8-naphtfayridin-3-yr)acrylate; A reaction vessel was charged with 6-bromo-l,8-naphthyridin-2(lH)-one (1.5g, 6.69 mmol), tert-bxyl acrylate (4.86 mL, 33.45 mmol), and (J-Pr)2EtN (3.5 niL, 20.07 mmol) followed by DMF (40 mL). The solution was de-oxygenated with argon for 20 min. The mixture was treated with Pd(OAc)2 (150 mg, 0.67 mmol) and P(o-tol)3 (407 mg, 1.34 mmol) then heated to 100 0C for 15 h (overnight). A TLC anlaysis indicated that only the starting arylhalide is present. At this time the mixture was a yellow suspension. To this mixture was added 20 DMSO (20 mL) and an additional 75 mg OfPd(OAc)2. The mixture was heated at 100 0C for 24 h. After cooling, the dark mixture was filtered through celite and the filter cake was rinsed with EtOAc (100 mL). The filtrate was extracted with EtOAc (2 x 100 mL). The combined organic fractions were washed with brine (2 x 100 mL), H2O (100 mL), dried over MgSO4 and filtered through a pad of silica gel. The filtrate was concentrated to about 50 mL then treated with about 150 mL hexanes to form a precipitate. The precipitate was filtered to give the product as a light brown solid. Yield: 700 mg(39%); 1H-NMR (300 MHz, DMSO-d6) delta 12.36 (s, IH), 8.83 (d, IH, J = 2.3 Hz), 8.53 (d, IH, J = 2.3 Hz), 7.89 (d, IH, J = 9.0 Hz), 7.64 (d, IH, J = 18.0 Hz), 6.65 (d, IH, J = 18.0 Hz), 6.62 (m, IH)5 1.51 (s, 9H); ESIMS m/z 273 [Ci5H16N2O3 + H]+

The chemical industry reduces the impact on the environment during synthesis,72754-05-3,6-Bromo-1,8-naphthyridin-2-ol,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; AFFINIUM PHARMACEUTICALS, INC.; WO2007/53131; (2007); A2;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to naphthyridine compound, name is 6-Bromo-1,8-naphthyridin-2-ol, and cas is 72754-05-3, its synthesis route is as follows.

Step 1: A mixture of 6-bromo-i,8-naphthyridin-2(1H)-one (1.0 equiv) and 2,5-dihydrofuran (10 equiv) in AcOH (0.05 M) was irradiated with UVA lamps (Rayonet reactor, RPR3 500 A bulbs) at RT overnight. The mixture was filtered, washing with EtOAc, and the solids were dried in vacuo. The so-obtained residue was purified via flash chromatography over silica gel, eluting with DCM and 0-20% EtOAc gradient to provide the title (rac)-2-bromo- 6a,6b,7,9,9a,9b-hexahydrofuro[3 ?,4?: 3 ,4]cyclobuta[ 1,2-c] [1 ,8]naphthyridin-6(5H)-one as a yellow solid in 9% yield. ?H NIVIR (400 IVIHz, DMSO-d6) oe 10.60 (s, 1H), 8.20 (m, 1H), 7.85 (m, 1H), 4.13 (d,J= 9.4 Hz, 1H), 3.97 (d,J= 9.6 Hz, 1H), 3.38 (m, 3H), 3.06 (d,J 8.9, 5.1 Hz, 1H), 2.90 (dd, J= 9.7, 4.4 Hz, 1H), 2.84 (m, 1H). LCMS (m/z) (M+H) = 295.1/297.1, Rt = 0.69 mm.

72754-05-3, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,72754-05-3 ,6-Bromo-1,8-naphthyridin-2-ol, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; NOVARTIS AG; AVERSA, Robert John; BURGER, Matthew T.; DILLON, Michael Patrick; DINEEN JR., Thomas A.; KARKI, Rajesh; RAMURTHY, Savithri; RAUNIYAR, Vivek; ROBINSON, Richard; SARVER, Patrick James; (374 pag.)WO2017/103824; (2017); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

Related Products of 72754-05-3, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.72754-05-3, Name is 6-Bromo-1,8-naphthyridin-2-ol, molecular formula is C8H5BrN2O. In a article£¬once mentioned of 72754-05-3

NOVARTIS AG; AVERSA, Robert John; BURGER, Matthew T.; DILLON, Michael Patrick; DINEEN JR., Thomas A.; KARKI, Rajesh; RAMURTHY, Savithri; RAUNIYAR, Vivek; ROBINSON, Richard; SARVER, Patrick James

The present invention provides compounds of Formula (A): (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent, and methods of using the compositions and combinations to treat conditions including cancers.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 72754-05-3

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1,641-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N635 – PubChem

Synthetic Route of 72754-05-3, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 72754-05-3, 6-Bromo-1,8-naphthyridin-2-ol, introducing its new discovery.

OTSUKA PHARMACEUTICAL CO., LTD.; ABUDUSAIMI, Mamuti; YE, Fangguo; SUN, Jiangqin; MIYAMOTO, Hisashi; CHENG, Jay-Fei; OKA, Daisuke

The present invention provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by 1 to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile-associated diarrhea.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 72754-05-3. In my other articles, you can also check out more blogs about 72754-05-3

Reference£º
1,639-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N633 – PubChem

Reference of 72754-05-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.72754-05-3, Name is 6-Bromo-1,8-naphthyridin-2-ol, molecular formula is C8H5BrN2O. In a Patent£¬once mentioned of 72754-05-3

BRISTOL-MYERS SQUIBB COMPANY; King, Dalton; Macor, John E.; Olson, Richard E.; Iwuagwu, Christiana I.; Karageorge, George N.

The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, antagonists of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system. Formule (I)

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Reference£º
1,642-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N636 – PubChem

72754-05-3, Name is 6-Bromo-1,8-naphthyridin-2-ol, belongs to naphthyridine compound, is a common compound. Recommanded Product: 72754-05-3In an article, once mentioned the new application about 72754-05-3.

NATCO PHARMA LIMITED; KOMPELLA, Amala; GAMPA, Venugopala Krishna; GANGANAMONI, Srinivasulu; SIRIGIREDDY, Balakrishna Reddy; ADIBHATLA, Kali Satya Bhujanga Rao; NANNAPANENI, Venkaiah Chowdary

The present invention relates to novel antiproliferative1H-1, 8-naphthyridin-2-ones of the general formula (I) or pharmaceutically acceptable salts thereof: In which the variable groups are as defined herein, and their preparation and use in therapeutic treatment of disorders related to inhibition of tyrosine kinases in warm blooded animals. The compounds can overcome imatinib induced drug resistance.

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Reference£º
1,643-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N637 – PubChem

Related Products of 72754-05-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.72754-05-3, Name is 6-Bromo-1,8-naphthyridin-2-ol, molecular formula is C8H5BrN2O. In a Patent£¬once mentioned of 72754-05-3

OTSUKA PHARMACEUTICAL CO., LTD.; ABUDUSAIMI, Mamuti; YE, Fangguo; SUN, Jiangqin; MIYAMOTO, Hisashi; CHENG, Jay-Fei; OKA, Daisuke

The present invention provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R3 is 7-oxo-7,8-dihydro-l,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile-associated diarrhea

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 72754-05-3, and how the biochemistry of the body works.Related Products of 72754-05-3

Reference£º
1,640-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N634 – PubChem

72754-05-3, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 72754-05-3

AFFINIUM PHARMACEUTICALS, INC.

In part, the present invention is directed to antibacterial compounds

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 72754-05-3, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 72754-05-3

Reference£º
1,644-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N638 – PubChem

72754-05-3, 6-Bromo-1,8-naphthyridin-2-ol is a naphthyridine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,72754-05-3

Example 7 Synthesis of boronic acid 7Reaction reagents and conditions: a. 1 ) NaH, THF, r.t.; 2) nBuLi, B(OiPr)3, -70C to 0C7.1 Boronic acid 7: To a solution of compound 6 (10 g, 44.44 mmol) in dry tetrahydrofuran (350 mL) was added sodium hydride(2 g, 66.66 mmol, 80% dispersion) at 0C. After the mixture was stirred at room temperature for 30 min, the mixture was cooled below -60C in a dry ice/acetone bath, and n- butyllithium (70 mL, 112 mmol, 1.6 M in hexane) was added over 30 min. The mixture was kept stirring for another 30 min, then triisopropyl borate (40 mL, 177 mmol) was added dropwise. The reaction mixture was stirred for 10 min, and then warmed to 0C slowly in an ice bath. HC1 (5 N) was added to the mixture to adjust pH = 3-4, and the mixture was stirred for 20 min. Aq. NaOH was added to the mixture to adjust pH = 10. After filtration, the organic layer was separated. The aqueous layer was extracted with a mixture of ethyl acetate/THF (4/1; 2 x 120 mL) and EtOAc (100 mL) . The aqueous layer was adjusted to pH = 5-6 with HC1. The precipitate thus formed was collected by filtration and dried to give boronic acid 7 (3.5 g, 41%) a white solid.

72754-05-3 6-Bromo-1,8-naphthyridin-2-ol 12520144, anaphthyridine compound, is more and more widely used in various fields.

Reference£º
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; ABUDUSAIMI, Mamuti; YE, Fangguo; SUN, Jiangqin; MIYAMOTO, Hisashi; CHENG, Jay-Fei; OKA, Daisuke; WO2013/29548; (2013); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

72754-05-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6-Bromo-1,8-naphthyridin-2-ol, cas is 72754-05-3,the naphthyridine compound, it is a common compound, a new synthetic route is introduced below.

Step 1: To a stirred solution of 6-bromo-1,8-naphthyridin-2(1H)-one (1 equiv) in DIVIF (0.2 M) at 25 C were added cesium carbonate (1.3 equiv) and iodoethane (1.1 equiv) and the reaction was stirred for 30 mm. The mixture was poured onto water and extracted three times with ethyl acetate. The combined organics were washed with water and brine, dried over MgSO4, filtered, and concentrated to give 6-bromo-1-ethyl-1,8-naphthyridin-2(1H)-one as a yellow solid in 87% yield, which was used without further purification. LCMS (m/z) (M+H) = 253.0/255.0, Rt = 0.91 mm

The chemical industry reduces the impact on the environment during synthesis,72754-05-3,6-Bromo-1,8-naphthyridin-2-ol,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; NOVARTIS AG; AVERSA, Robert John; BURGER, Matthew T.; DILLON, Michael Patrick; DINEEN JR., Thomas A.; KARKI, Rajesh; RAMURTHY, Savithri; RAUNIYAR, Vivek; ROBINSON, Richard; SARVER, Patrick James; (374 pag.)WO2017/103824; (2017); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem