Category: 65438-97-3

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone, is researched, Molecular C7H8BrNO, CAS is 65438-97-3, about Electrochemical diselenylation of indolizines via intermolecular C-Se formation with 2-methylpyridines, α-bromoketones and diselenides, the main research direction is selenylindolizine preparation; electrochem cyclocondensation selenylation methylpyridine bromomethylaryl ketone diselenide.Related Products of 65438-97-3.

2-Methylpyridines, aryl bromomethyl ketones, and diselenides underwent electrochem. three-component cyclocondensation and selenylation reactions mediated by KI and K2CO3 in aqueous DMF to yield diselenylindolizines such as I [R = Ph, 4-R1C6H4, 3-R2C6H4, 2-FC6H4, 2,4-Cl2C6H3, 3,4-Cl2C6H3, 3,4-(MeO)2C6H3, 2-naphthyl, 1,3-benzodioxol-5-yl, 2-dibenzofuranyl, 1-methyl-2-pyrrolyl; R1 = Me, MeO, i-Bu, F, Cl, Br, I, F3C, Ph, PhCH2O, MeSO2; R2 = Me, MeO, Cl, Br].

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone(SMILESS: CN1C(C(CBr)=O)=CC=C1,cas:65438-97-3) is researched.Safety of 4-Methyl-1,8-naphthyridine. The article 《Design, synthesis and biological activities of benzo[d]imidazo[1,2-a]imidazole derivatives as TRPM2-specific inhibitors》 in relation to this compound, is published in European Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:65438-97-3).

Transient receptor potential melastatin 2 (TRPM2) channel is associated with ischemia/reperfusion injury, inflammation, cancer and neurodegenerative diseases. However, the lack of specific inhibitors impedes the development of TRPM2 targeted therapeutic agents. To develop a selective TRPM2 inhibitor, three-dimensional similarity-based screening strategy was employed using the energy-minimized conformation of non-selective TRPM2 inhibitor 2-APB as the query structure, which resulted in the discovery of a novel tricyclic TRPM2 inhibitor I with benzo[d]imidazo[1,2-a]imidazole skeleton. A series of I derivatives were subsequently synthesized and evaluated using calcium imaging and electrophysiol. approaches. Among them, preferred compounds II and III inhibited the TRPM2 channel with micromolar half-maximal inhibitory concentration values and exhibited TRPM2 selectivity over the TRPM8 channel, TRPV1 channel, InsP3 receptor and Orai channel. The anal. of structure-activity relationship provides valuable insights for further development of selective TRPM2 inhibitors. Neuroprotection assay showed that II and III could effectively reduce the mortality of SH-SY5Y cells induced by H2O2. These findings enrich the structure types of existing TRPM2 inhibitors and might provide a new tool for the study of TRPM2 function in Reactive oxygen species (ROS) -related diseases.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemical Communications (Cambridge, United Kingdom) called Electrochemical diselenylation of indolizines via intermolecular C-Se formation with 2-methylpyridines, α-bromoketones and diselenides, Author is Li, Junxuan; Liu, Xiang; Deng, Jiadi; Huang, Yingshan; Pan, Zihao; Yu, Yue; Cao, Hua, which mentions a compound: 65438-97-3, SMILESS is CN1C(C(CBr)=O)=CC=C1, Molecular C7H8BrNO, Application In Synthesis of 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone.

2-Methylpyridines, aryl bromomethyl ketones, and diselenides underwent electrochem. three-component cyclocondensation and selenylation reactions mediated by KI and K2CO3 in aqueous DMF to yield diselenylindolizines such as I [R = Ph, 4-R1C6H4, 3-R2C6H4, 2-FC6H4, 2,4-Cl2C6H3, 3,4-Cl2C6H3, 3,4-(MeO)2C6H3, 2-naphthyl, 1,3-benzodioxol-5-yl, 2-dibenzofuranyl, 1-methyl-2-pyrrolyl; R1 = Me, MeO, i-Bu, F, Cl, Br, I, F3C, Ph, PhCH2O, MeSO2; R2 = Me, MeO, Cl, Br].

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Recommanded Product: 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone, is researched, Molecular C7H8BrNO, CAS is 65438-97-3, about Visible-Light-Mediated Addition of Phenacyl Bromides onto Cyclopropenes. Author is Dange, Nitin S.; Hussain Jatoi, Ashique; Robert, Frederic; Landais, Yannick.

In the presence of the photocatalyst fac-Ir(ppy)3 (ppy = 2-pyridinylphenyl), K2CO3, and LiBr in DMF, aryl bromomethyl ketones such as phenacyl bromide underwent chemoselective photochem. addition and cyclization reactions with cyclopropenecarboxylates such as I under irradiation with blue LED at 0° followed by base-mediated ring opening at 60° without irradiation to give oxonaphthaleneacetates such as II and oxobenzo-fused heterocyclylacetates in 16-51% yields. Nonracemic II was prepared in 40% yield and 95:5 er by the reaction of nonracemic I (95:5 er) with phenacyl bromide. Oxonaphthaleneacetates derived from this reaction can be further converted in one or two steps to polycyclic products such as naphthopyranacetate III and benzoindeneacetate IV.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Howes, Peter D.; Cleasby, Anne; Evans, Derek N.; Feilden, Helen; Smith, Paul W.; Sollis, Steven L.; Taylor, Neil; Wonacott, Alan J. published an article about the compound: 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone( cas:65438-97-3,SMILESS:CN1C(C(CBr)=O)=CC=C1 ).Name: 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:65438-97-3) through the article.

Two methods for the synthesis of 4-acetylaminobenzoic acids substituted at the 3-position with imidazoles are described. Thus, 4-acetylamino-3-aminobenzoic acid tert-Bu ester was N-alkylated with RCH2COBr (R = Ph, Et, benzofuran-3-yl, etc.) followed by cyclization with cyanamide and hydrolysis to give imidazolylbenzoic acids I (R1 = Ph, furyl, Et, etc.; R2 = NH2). Imidazolylbenzoic acids I (R1 = H; R2 = NH2, H, Et) were prepared by addition of the appropriate imidazole to 3-fluoro-4-nitrobenzoic acid tert-Bu ester followed by reduction of the nitro group, acetylation, and hydrolysis. Many of the compounds are inhibitors of influenza virus sialidases with levels of activity similar to the recently described 4-acetylamino-3-guanidino-benzoic acid (BANA 113).

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Electrochemical diselenylation of indolizines via intermolecular C-Se formation with 2-methylpyridines, α-bromoketones and diselenides, published in 2020, which mentions a compound: 65438-97-3, Name is 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone, Molecular C7H8BrNO, Formula: C7H8BrNO.

2-Methylpyridines, aryl bromomethyl ketones, and diselenides underwent electrochem. three-component cyclocondensation and selenylation reactions mediated by KI and K2CO3 in aqueous DMF to yield diselenylindolizines such as I [R = Ph, 4-R1C6H4, 3-R2C6H4, 2-FC6H4, 2,4-Cl2C6H3, 3,4-Cl2C6H3, 3,4-(MeO)2C6H3, 2-naphthyl, 1,3-benzodioxol-5-yl, 2-dibenzofuranyl, 1-methyl-2-pyrrolyl; R1 = Me, MeO, i-Bu, F, Cl, Br, I, F3C, Ph, PhCH2O, MeSO2; R2 = Me, MeO, Cl, Br].

Here is just a brief introduction to this compound(65438-97-3)Formula: C7H8BrNO, more information about the compound(2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone) is in the article, you can click the link below.

Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Dange, Nitin S.; Hussain Jatoi, Ashique; Robert, Frederic; Landais, Yannick researched the compound: 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone( cas:65438-97-3 ).Safety of 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone.They published the article 《Visible-Light-Mediated Addition of Phenacyl Bromides onto Cyclopropenes》 about this compound( cas:65438-97-3 ) in Organic Letters. Keywords: oxonaphthaleneacetate oxobenzo fused heterocyclylacetate chemoselective preparation; photochem addition cyclization aryl bromomethyl ketone cyclopropenecarboxylate ring opening; iridium photocatalyst addition cyclization aryl bromomethyl ketone cyclopropenecarboxylate; nonracemic cyclopropene stereoselective photochem addition cyclization phenacyl bromide. We’ll tell you more about this compound (cas:65438-97-3).

In the presence of the photocatalyst fac-Ir(ppy)3 (ppy = 2-pyridinylphenyl), K2CO3, and LiBr in DMF, aryl bromomethyl ketones such as phenacyl bromide underwent chemoselective photochem. addition and cyclization reactions with cyclopropenecarboxylates such as I under irradiation with blue LED at 0° followed by base-mediated ring opening at 60° without irradiation to give oxonaphthaleneacetates such as II and oxobenzo-fused heterocyclylacetates in 16-51% yields. Nonracemic II was prepared in 40% yield and 95:5 er by the reaction of nonracemic I (95:5 er) with phenacyl bromide. Oxonaphthaleneacetates derived from this reaction can be further converted in one or two steps to polycyclic products such as naphthopyranacetate III and benzoindeneacetate IV.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Electric Literature of C7H8BrNO. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone, is researched, Molecular C7H8BrNO, CAS is 65438-97-3, about Pyrrole analogues of chloramphenicol. I. Synthesis and antibacterial activity of dl-threo-1-(1-methyl-4-nitro-pyrrole-2-yl)-2-dichloroacetamidopropane-1,3-diol. Author is Krajewska, Dorota; Dabrowska, Marta; Jakoniuk, Piotr; Rozanski, Andrzej.

The seven step synthesis of the title pyrrole analog (I) of chloramphenicol was described. The compound exhibits a significant antibacterial activity, over the 12-50% range of the chloramphenicol activity.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Synthetic Route of C7H8BrNO. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone, is researched, Molecular C7H8BrNO, CAS is 65438-97-3, about Visible-Light-Mediated Addition of Phenacyl Bromides onto Cyclopropenes. Author is Dange, Nitin S.; Hussain Jatoi, Ashique; Robert, Frederic; Landais, Yannick.

In the presence of the photocatalyst fac-Ir(ppy)3 (ppy = 2-pyridinylphenyl), K2CO3, and LiBr in DMF, aryl bromomethyl ketones such as phenacyl bromide underwent chemoselective photochem. addition and cyclization reactions with cyclopropenecarboxylates such as I under irradiation with blue LED at 0° followed by base-mediated ring opening at 60° without irradiation to give oxonaphthaleneacetates such as II and oxobenzo-fused heterocyclylacetates in 16-51% yields. Nonracemic II was prepared in 40% yield and 95:5 er by the reaction of nonracemic I (95:5 er) with phenacyl bromide. Oxonaphthaleneacetates derived from this reaction can be further converted in one or two steps to polycyclic products such as naphthopyranacetate III and benzoindeneacetate IV.

There is still a lot of research devoted to this compound(SMILES：CN1C(C(CBr)=O)=CC=C1)Synthetic Route of C7H8BrNO, and with the development of science, more effects of this compound(65438-97-3) can be discovered.

Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Electric Literature of C7H8BrNO. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone, is researched, Molecular C7H8BrNO, CAS is 65438-97-3, about Visible-Light-Mediated Addition of Phenacyl Bromides onto Cyclopropenes. Author is Dange, Nitin S.; Hussain Jatoi, Ashique; Robert, Frederic; Landais, Yannick.

In the presence of the photocatalyst fac-Ir(ppy)3 (ppy = 2-pyridinylphenyl), K2CO3, and LiBr in DMF, aryl bromomethyl ketones such as phenacyl bromide underwent chemoselective photochem. addition and cyclization reactions with cyclopropenecarboxylates such as I under irradiation with blue LED at 0° followed by base-mediated ring opening at 60° without irradiation to give oxonaphthaleneacetates such as II and oxobenzo-fused heterocyclylacetates in 16-51% yields. Nonracemic II was prepared in 40% yield and 95:5 er by the reaction of nonracemic I (95:5 er) with phenacyl bromide. Oxonaphthaleneacetates derived from this reaction can be further converted in one or two steps to polycyclic products such as naphthopyranacetate III and benzoindeneacetate IV.

If you want to learn more about this compound(2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone)Electric Literature of C7H8BrNO, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(65438-97-3).

Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem