Category: 65438-97-3

Synthetic Route of C7H8BrNO. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone, is researched, Molecular C7H8BrNO, CAS is 65438-97-3, about Pyrrole analogues of chloramphenicol. I. Synthesis and antibacterial activity of dl-threo-1-(1-methyl-4-nitro-pyrrole-2-yl)-2-dichloroacetamidopropane-1,3-diol. Author is Krajewska, Dorota; Dabrowska, Marta; Jakoniuk, Piotr; Rozanski, Andrzej.

The seven step synthesis of the title pyrrole analog (I) of chloramphenicol was described. The compound exhibits a significant antibacterial activity, over the 12-50% range of the chloramphenicol activity.

After consulting a lot of data, we found that this compound(65438-97-3)Synthetic Route of C7H8BrNO can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Quality Control of 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone, is researched, Molecular C7H8BrNO, CAS is 65438-97-3, about Electrochemical diselenylation of indolizines via intermolecular C-Se formation with 2-methylpyridines, α-bromoketones and diselenides. Author is Li, Junxuan; Liu, Xiang; Deng, Jiadi; Huang, Yingshan; Pan, Zihao; Yu, Yue; Cao, Hua.

2-Methylpyridines, aryl bromomethyl ketones, and diselenides underwent electrochem. three-component cyclocondensation and selenylation reactions mediated by KI and K2CO3 in aqueous DMF to yield diselenylindolizines such as I [R = Ph, 4-R1C6H4, 3-R2C6H4, 2-FC6H4, 2,4-Cl2C6H3, 3,4-Cl2C6H3, 3,4-(MeO)2C6H3, 2-naphthyl, 1,3-benzodioxol-5-yl, 2-dibenzofuranyl, 1-methyl-2-pyrrolyl; R1 = Me, MeO, i-Bu, F, Cl, Br, I, F3C, Ph, PhCH2O, MeSO2; R2 = Me, MeO, Cl, Br].

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Magdesieva, N. N.; Koloskova, N. M.; Le Nguyen Nghi published an article about the compound: 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone( cas:65438-97-3,SMILESS:CN1C(C(CBr)=O)=CC=C1 ).Formula: C7H8BrNO. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:65438-97-3) through the article.

Reaction of BrCH2COAr with Me2Se gave [Me2Se+CH2COAr] Br-, which with diphenylcyclopropenone gave 80-95% I (Ar = Ph, 2-thienyl, selenophene-2-yl, 1-methylpyrrol-2-yl), which with MeNH2 gave the corresponding II.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Visible-Light-Mediated Addition of Phenacyl Bromides onto Cyclopropenes, published in 2017-07-07, which mentions a compound: 65438-97-3, mainly applied to oxonaphthaleneacetate oxobenzo fused heterocyclylacetate chemoselective preparation; photochem addition cyclization aryl bromomethyl ketone cyclopropenecarboxylate ring opening; iridium photocatalyst addition cyclization aryl bromomethyl ketone cyclopropenecarboxylate; nonracemic cyclopropene stereoselective photochem addition cyclization phenacyl bromide, Recommanded Product: 65438-97-3.

In the presence of the photocatalyst fac-Ir(ppy)3 (ppy = 2-pyridinylphenyl), K2CO3, and LiBr in DMF, aryl bromomethyl ketones such as phenacyl bromide underwent chemoselective photochem. addition and cyclization reactions with cyclopropenecarboxylates such as I under irradiation with blue LED at 0° followed by base-mediated ring opening at 60° without irradiation to give oxonaphthaleneacetates such as II and oxobenzo-fused heterocyclylacetates in 16-51% yields. Nonracemic II was prepared in 40% yield and 95:5 er by the reaction of nonracemic I (95:5 er) with phenacyl bromide. Oxonaphthaleneacetates derived from this reaction can be further converted in one or two steps to polycyclic products such as naphthopyranacetate III and benzoindeneacetate IV.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

COA of Formula: C7H8BrNO. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone, is researched, Molecular C7H8BrNO, CAS is 65438-97-3, about Pyrrole analogues of chloramphenicol. I. Synthesis and antibacterial activity of dl-threo-1-(1-methyl-4-nitro-pyrrole-2-yl)-2-dichloroacetamidopropane-1,3-diol. Author is Krajewska, Dorota; Dabrowska, Marta; Jakoniuk, Piotr; Rozanski, Andrzej.

The seven step synthesis of the title pyrrole analog (I) of chloramphenicol was described. The compound exhibits a significant antibacterial activity, over the 12-50% range of the chloramphenicol activity.

Compounds in my other articles are similar to this one(2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone)COA of Formula: C7H8BrNO, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone(SMILESS: CN1C(C(CBr)=O)=CC=C1,cas:65438-97-3) is researched.Application of 65438-97-3. The article 《4-Acetylamino-3-(imidazol-1-yl)-benzoic acids as novel inhibitors of influenza sialidase》 in relation to this compound, is published in European Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:65438-97-3).

Two methods for the synthesis of 4-acetylaminobenzoic acids substituted at the 3-position with imidazoles are described. Thus, 4-acetylamino-3-aminobenzoic acid tert-Bu ester was N-alkylated with RCH2COBr (R = Ph, Et, benzofuran-3-yl, etc.) followed by cyclization with cyanamide and hydrolysis to give imidazolylbenzoic acids I (R1 = Ph, furyl, Et, etc.; R2 = NH2). Imidazolylbenzoic acids I (R1 = H; R2 = NH2, H, Et) were prepared by addition of the appropriate imidazole to 3-fluoro-4-nitrobenzoic acid tert-Bu ester followed by reduction of the nitro group, acetylation, and hydrolysis. Many of the compounds are inhibitors of influenza virus sialidases with levels of activity similar to the recently described 4-acetylamino-3-guanidino-benzoic acid (BANA 113).

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone, is researched, Molecular C7H8BrNO, CAS is 65438-97-3, about Electrochemical diselenylation of indolizines via intermolecular C-Se formation with 2-methylpyridines, α-bromoketones and diselenides.Application of 65438-97-3.

2-Methylpyridines, aryl bromomethyl ketones, and diselenides underwent electrochem. three-component cyclocondensation and selenylation reactions mediated by KI and K2CO3 in aqueous DMF to yield diselenylindolizines such as I [R = Ph, 4-R1C6H4, 3-R2C6H4, 2-FC6H4, 2,4-Cl2C6H3, 3,4-Cl2C6H3, 3,4-(MeO)2C6H3, 2-naphthyl, 1,3-benzodioxol-5-yl, 2-dibenzofuranyl, 1-methyl-2-pyrrolyl; R1 = Me, MeO, i-Bu, F, Cl, Br, I, F3C, Ph, PhCH2O, MeSO2; R2 = Me, MeO, Cl, Br].

As far as I know, this compound(65438-97-3)Application of 65438-97-3 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone( cas:65438-97-3 ) is researched.Product Details of 65438-97-3.Howes, Peter D.; Cleasby, Anne; Evans, Derek N.; Feilden, Helen; Smith, Paul W.; Sollis, Steven L.; Taylor, Neil; Wonacott, Alan J. published the article 《4-Acetylamino-3-(imidazol-1-yl)-benzoic acids as novel inhibitors of influenza sialidase》 about this compound( cas:65438-97-3 ) in European Journal of Medicinal Chemistry. Keywords: acetylaminoimidazolylbenzoic acid preparation influenza sialidase inhibitor; imidazolylbenzoic acid preparation influenza sialidase inhibitor; benzoic acid imidazolyl preparation influenza sialidase inhibitor; virucide anti viral agent acetylaminoimidazolylbenzoic acid. Let’s learn more about this compound (cas:65438-97-3).

Two methods for the synthesis of 4-acetylaminobenzoic acids substituted at the 3-position with imidazoles are described. Thus, 4-acetylamino-3-aminobenzoic acid tert-Bu ester was N-alkylated with RCH2COBr (R = Ph, Et, benzofuran-3-yl, etc.) followed by cyclization with cyanamide and hydrolysis to give imidazolylbenzoic acids I (R1 = Ph, furyl, Et, etc.; R2 = NH2). Imidazolylbenzoic acids I (R1 = H; R2 = NH2, H, Et) were prepared by addition of the appropriate imidazole to 3-fluoro-4-nitrobenzoic acid tert-Bu ester followed by reduction of the nitro group, acetylation, and hydrolysis. Many of the compounds are inhibitors of influenza virus sialidases with levels of activity similar to the recently described 4-acetylamino-3-guanidino-benzoic acid (BANA 113).

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Design, synthesis and biological activities of benzo[d]imidazo[1,2-a]imidazole derivatives as TRPM2-specific inhibitors, published in 2021-12-05, which mentions a compound: 65438-97-3, Name is 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone, Molecular C7H8BrNO, Category: naphthyridine.

Transient receptor potential melastatin 2 (TRPM2) channel is associated with ischemia/reperfusion injury, inflammation, cancer and neurodegenerative diseases. However, the lack of specific inhibitors impedes the development of TRPM2 targeted therapeutic agents. To develop a selective TRPM2 inhibitor, three-dimensional similarity-based screening strategy was employed using the energy-minimized conformation of non-selective TRPM2 inhibitor 2-APB as the query structure, which resulted in the discovery of a novel tricyclic TRPM2 inhibitor I with benzo[d]imidazo[1,2-a]imidazole skeleton. A series of I derivatives were subsequently synthesized and evaluated using calcium imaging and electrophysiol. approaches. Among them, preferred compounds II and III inhibited the TRPM2 channel with micromolar half-maximal inhibitory concentration values and exhibited TRPM2 selectivity over the TRPM8 channel, TRPV1 channel, InsP3 receptor and Orai channel. The anal. of structure-activity relationship provides valuable insights for further development of selective TRPM2 inhibitors. Neuroprotection assay showed that II and III could effectively reduce the mortality of SH-SY5Y cells induced by H2O2. These findings enrich the structure types of existing TRPM2 inhibitors and might provide a new tool for the study of TRPM2 function in Reactive oxygen species (ROS) -related diseases.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem

Quality Control of 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Bromo-1-(1-methyl-1H-pyrrol-2-yl)ethanone, is researched, Molecular C7H8BrNO, CAS is 65438-97-3, about Pyrrole analogues of chloramphenicol. I. Synthesis and antibacterial activity of dl-threo-1-(1-methyl-4-nitro-pyrrole-2-yl)-2-dichloroacetamidopropane-1,3-diol. Author is Krajewska, Dorota; Dabrowska, Marta; Jakoniuk, Piotr; Rozanski, Andrzej.

The seven step synthesis of the title pyrrole analog (I) of chloramphenicol was described. The compound exhibits a significant antibacterial activity, over the 12-50% range of the chloramphenicol activity.

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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem