Category: 55716-28-4

Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of 8-Methoxy-1,7-naphthyridin-6-amine, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 55716-28-4

AMGEN INC.

The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X1, X2, R1 and Z are as defined herein.

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Reference£º
1,502-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N496 – PubChem

55716-28-4, Name is 8-Methoxy-1,7-naphthyridin-6-amine, belongs to naphthyridine compound, is a common compound. Recommanded Product: 55716-28-4In an article, once mentioned the new application about 55716-28-4.

The synthesis of a 6,8-disubstituted 1,7-naphthyridine 1 and its characterization as a potent and selective phosphodiesterase type 4D inhibitor (IC50=1.5nM) are described. The compound inhibited TNFalpha-release from human peripheral blood mononuclear cells and was orally active in a model of adjuvant-induced arthritis in rats.

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Reference£º
1,504-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N498 – PubChem

55716-28-4, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 55716-28-4, molcular formula is C9H9N3O, introducing its new discovery.

Novartis AG

Novel 8-aryl-1,7-naphthyridines, in free or salt form, are PDE IV inhibitors and are thus useful as pharmaceuticals, e.g. for asthma therapy. Preferred compounds include compounds of formulae (I and II) wherein the R groups are as defined. Pharmaceutical compositions comprising the compounds, processes for preparation of the compounds and novel intermediates for use in the processes are disclosed.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 55716-28-4, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 55716-28-4

Reference£º
1,503-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N497 – PubChem

55716-28-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 8-Methoxy-1,7-naphthyridin-6-amine, cas is 55716-28-4,the naphthyridine compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 76; N-(2-Chloro-5-(8-methoxy-l,7-naphthyridin-6-yl)pyridin-3-yl)-4- fluorobenzenesulfonamide; (1) 8-methoxy-l,7-naphthyridin-6-yl trifluoromethanesulfonate.; (Some starting materials may be obtained from Parkway Scientific, NY, NY) To a 50 mL round- bottomed flask was added 8-methoxy-l,7-naphthyridin-6-amine (175 mg, 999 mumol), DMF (1.6 mL), trifluoromethane sulfonic acid (0.8 mL, 9041 mumol), sodium nitrite (0.06 mL, 1998 mumol). The reaction mixture was stirred at room temperature for 2 h. The reaction mixture was diluted with water (10 mL) and extracted with EtOAc (2 x 40 mL). The organic extract was washed with water (10 mL), satd NaCl (10 mL), dried over Na2SO4, filtered and concentrated in vacuo and the residue was purified by silica gel chromatography, eluting with 60% EtOAc/hexanes to give 8-methoxy-l,7-naphthyridin-6-yl trifluoromethanesulfonate (126mg, 41% yield). MS (ESI pos. ion) m/z calc’d for Ci0H7F3N2O4S: 308.0; found 309.0. 1H NMR (300 MHz, CHLOROFORM-^) delta ppm 4.25 (s, 3 H) 7.13 (s, 1 H) 7.70 (dd, J=8.33, 4.24 Hz, 1 H) 8.19 (dd, J=8.40, 1.53 Hz, 1 H) 9.04 (dd, J=4.24, 1.61 Hz, 1 H)

The chemical industry reduces the impact on the environment during synthesis,55716-28-4,8-Methoxy-1,7-naphthyridin-6-amine,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; AMGEN INC.; WO2009/155121; (2009); A2;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

It is a common heterocyclic compound, the naphthyridine compound, 8-Methoxy-1,7-naphthyridin-6-amine, cas is 55716-28-4 its synthesis route is as follows.

B. 6-Trifluoromethylsulfonyloxy-8-methoxy-1,7-naphthyridine To a solution of 6-amino-8-methoxy-1,7-naphthyridine (19 g, 0.108 mol) in a 1:1 mixture of water and trifluoromethane sulfonic acid (380 ml) is carefully added a solution of sodium nitrite (11.2 g, 0.162 mol) in water (40 ml) at 0 C. After 1 h the cooling bath is removed and the reaction mixture stirred for an other hour at ambient temperature. Then, ethyl acetate (500 ml) is added and the solution is neutralized by adding sodium bicarbonate (4N, 1 l). The water phase is extracted again with ethyl acetate (3*500 ml). The organic solvent is evaporated and the crude product is purified by flash column chromatography on silica gel (20:3 toluene/acetone) affording the title compound. M+308; Melting point 99-101 C.

55716-28-4, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,55716-28-4 ,8-Methoxy-1,7-naphthyridin-6-amine, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Novartis AG; US6136821; (2000); A;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO251,mainly used in chemical industry, its synthesis route is as follows.,55716-28-4

B. 6-Trifluoromethylsulfonyloxy-8-methoxy-1,7-naphthyridine To a solution of 6-amino-8-methoxy-1,7-naphthyridine (19 g, 0.108 mol) in a 1:1 mixture of water and trifluoromethane sulfonic acid (380 ml) is carefully added a solution of sodium nitrite (11.2 g, 0.162 mol) in water (40 ml) at 0 C. After 1 h the cooling bath is removed and the reaction mixture stirred for an other hour at ambient temperature. Then, ethyl acetate (500 ml) is added and the solution is neutralized by adding sodium bicarbonate (4N, 1 l). The water phase is extracted again with ethyl acetate (3*500 ml). The organic solvent is evaporated and the crude product is purified by flash column chromatography on silica gel (20:3 toluene/acetone) affording the title compound. M+308; Melting point 99-101 C.

With the complex challenges of chemical substances, we look forward to future research findings about 8-Methoxy-1,7-naphthyridin-6-amine,belong naphthyridine compound

Reference£º
Patent; Novartis AG; US6136821; (2000); A;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

55716-28-4, 8-Methoxy-1,7-naphthyridin-6-amine is a naphthyridine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,55716-28-4

B. 6-Trifluoromethylsulfonyloxy-8-methoxy-1,7-naphthyridine To a solution of 6-amino-8-methoxy-1,7-naphthyridine (19 g, 0.108 mol) in a 1:1 mixture of water and trifluoromethane sulfonic acid (380 ml) is carefully added a solution of sodium nitrite (11.2 g, 0.162 mol) in water (40 ml) at 0 C. After 1 h the cooling bath is removed and the reaction mixture stirred for an other hour at ambient temperature. Then, ethyl acetate (500 ml) is added and the solution is neutralized by adding sodium bicarbonate (4N, 1 l). The water phase is extracted again with ethyl acetate (3*500 ml). The organic solvent is evaporated and the crude product is purified by flash column chromatography on silica gel (20:3 toluene/acetone) affording the title compound. M+308; Melting point 99-101 C.

The synthetic route of 55716-28-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Novartis AG; US6136821; (2000); A;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55716-28-4,8-Methoxy-1,7-naphthyridin-6-amine,as a common compound, the synthetic route is as follows.,55716-28-4

EXAMPLE 76; N-(2-Chloro-5-(8-methoxy-l,7-naphthyridin-6-yl)pyridin-3-yl)-4- fluorobenzenesulfonamide; (1) 8-methoxy-l,7-naphthyridin-6-yl trifluoromethanesulfonate.; (Some starting materials may be obtained from Parkway Scientific, NY, NY) To a 50 mL round- bottomed flask was added 8-methoxy-l,7-naphthyridin-6-amine (175 mg, 999 mumol), DMF (1.6 mL), trifluoromethane sulfonic acid (0.8 mL, 9041 mumol), sodium nitrite (0.06 mL, 1998 mumol). The reaction mixture was stirred at room temperature for 2 h. The reaction mixture was diluted with water (10 mL) and extracted with EtOAc (2 x 40 mL). The organic extract was washed with water (10 mL), satd NaCl (10 mL), dried over Na2SO4, filtered and concentrated in vacuo and the residue was purified by silica gel chromatography, eluting with 60% EtOAc/hexanes to give 8-methoxy-l,7-naphthyridin-6-yl trifluoromethanesulfonate (126mg, 41% yield). MS (ESI pos. ion) m/z calc’d for Ci0H7F3N2O4S: 308.0; found 309.0. 1H NMR (300 MHz, CHLOROFORM-^) delta ppm 4.25 (s, 3 H) 7.13 (s, 1 H) 7.70 (dd, J=8.33, 4.24 Hz, 1 H) 8.19 (dd, J=8.40, 1.53 Hz, 1 H) 9.04 (dd, J=4.24, 1.61 Hz, 1 H)

As the paragraph descriping shows that 55716-28-4 is playing an increasingly important role.

Reference£º
Patent; AMGEN INC.; WO2009/155121; (2009); A2;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem