Category: 5423-54-1

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. name: 1,5-Naphthyridin-4-ol, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 5423-54-1, name is 1,5-Naphthyridin-4-ol. In an article£¬Which mentioned a new discovery about 5423-54-1

KIRIN BEER KABUSHIKI KAISHA

The present invention provides compounds of formula (I) or compounds of formula (II) and pharmaceutically acceptable salts or solvates thereof. An objective of the present invention is to provide compounds having TGFI? inhibitory activity.

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1,389-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N383 – PubChem

Reference of 5423-54-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.5423-54-1, Name is 1,5-Naphthyridin-4-ol, molecular formula is C8H6N2O. In a Patent£¬once mentioned of 5423-54-1

Shenzhen University; Yang Chuluo; Zhou Xue

The invention discloses a kind of fluorescent material, preparation method and application, wherein fluorescent material molecular structure of the general formula: R1 – R10 are each independently selected from H atom, deuterium atoms, to the electronic group or pulling in the electronic group a; and R1 – R10 a is at least one of the electron-donating groups, at least one of the is dragging the electronic group; Ar for electron-donating groups. The present invention provides fluorescent material, with twisted of – A D (Donor) (Acceptor) structure, on the long shaft to expand the molecular, improve the transition dipole moment horizontal orientation, to improve light output efficiency, thereby improving the light emitting efficiency of the electroluminescent device. In addition the material with a heat-activated delay fluorescent and aggregation induced characteristic, not only can realize 100% internal quantum efficiency, but also can reduce the aggregation caused by the luminescence quenching process. For the organic electroluminescent device in, its efficiency can be comparable with the phosphorescence, and greatly reduces the cost. (by machine translation)

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1,393-Naphthyridine – Wikipedia,
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Ebola virus (EBOV) causes a deadly hemorrhagic fever in humans and non-human primates. There is currently no FDA-approved vaccine or medication to counter this disease. Here, we report on the design, synthesis and anti-viral activities of two classes of compounds which show high potency against EBOV in both in vitro cell culture assays and in vivo mouse models Ebola viral disease. These compounds incorporate the structural features of cationic amphiphilic drugs (CAD), i.e they possess both a hydrophobic domain and a hydrophilic domain consisting of an ionizable amine functional group. These structural features enable easily diffusion into cells but once inside an acidic compartment their amine groups became protonated, ionized and remain trapped inside the acidic compartments such as late endosomes and lysosomes. These compounds, by virtue of their lysomotrophic functions, blocked EBOV entry. However, unlike other drugs containing a CAD moiety including chloroquine and amodiaquine, compounds reported in this study display faster kinetics of accumulation in the lysosomes, robust expansion of late endosome/lysosomes, relatively more potent suppression of lysosome fusion with other vesicular compartments and inhibition of cathepsins activities, all of which play a vital role in anti-EBOV activity. Furthermore, the diazachrysene 2 (ZSML08) that showed most potent activity against EBOV in in vitro cell culture assays also showed significant survival benefit with 100% protection in mouse models of Ebola virus disease, at a low dose of 10 mg/kg/day. Lastly, toxicity studies in vivo using zebrafish models suggest no developmental defects or toxicity associated with these compounds. Overall, these studies describe two new pharmacophores that by virtue of being potent lysosomotrophs, display potent anti-EBOV activities both in vitro and in vivo animal models of EBOV disease.

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1,401-Naphthyridine – Wikipedia,
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Electric Literature of 5423-54-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.5423-54-1, Name is 1,5-Naphthyridin-4-ol, molecular formula is C8H6N2O. In a Article£¬once mentioned of 5423-54-1

Lithium indenide (Li-Ind) or cyclopentadienide (Li-Cp) derivatives react as nucleophiles with 8-(methylsulfinyl)- 1,5-naphthyridine (Naph), leading to donor-functionalized ligands IndNaph or CpNaph, respectively. The new ligands comprise two N-donor atoms, which, for geometric reasons, cannot bind to the same metal atom. In complexes, where the metal atom is bound by the Cp or Ind moiety, the N5-donor atom is located in a distal position. The coordination behavior to Rh or Zr metal centers has been investigated. The Cp-based ligands show the expected chelating coordination mode with nu5-Cp and N coordination, whereas the indenyl units act as dihapto, trihapto, or pentahapto ligands. The dinuclear Rh(I) complex 12 shows a rare coordination geometry with two nu3 ligands bridging a Rh 2(CO)3 fragment.

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1,402-Naphthyridine – Wikipedia,
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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 5423-54-1, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 5423-54-1, name is 1,5-Naphthyridin-4-ol. In an article£¬Which mentioned a new discovery about 5423-54-1

Luminescent materials simultaneously exhibiting superior luminescence efficiency, thermally activated delayed fluorescence (TADF) and aggregation-induced emission (AIE) properties in the solid state are eagerly required for highly efficient non-doped organic light-emitting diodes (OLEDs). Herein, two new emitters, namely ND-AC and CND-AC, featuring a naphthyridine or cyano-naphthyridine segment as the electron acceptor and an acridine unit as the electron donor were designed, synthesized and investigated. The nearly orthogonal molecular configuration of the target emitters not only endows them with small energy differences between singlet and triplet states for ensuring TADF character but also affords a remarkable AIE feature. Due to the high photoluminescence quantum yields, and excellent TADF and AIE characteristics, the doped and non-doped OLEDs based on ND-AC exhibit outstanding performances with maximum external quantum efficiencies of 16.8% and 12.0%, respectively. These results demonstrate that the naphthyridine-based emitters have a promising application in OLEDs.

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1,406-Naphthyridine – Wikipedia,
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Electric Literature of 5423-54-1, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 5423-54-1, Name is 1,5-Naphthyridin-4-ol,introducing its new discovery.

4-Substituted 1,5-naphthyridines and their N-oxides were synthesized, and their structures and properties were studied.The IR and UV spectra of 4-hydroxy- and 4-methoxy-1,5-naphthyridines and their 1-oxides and 1-ethyl-4-oxo-1,4-dihydro-1,5-naphthyridine were examined.It is shown that 4-hydroxy-1,5-naphthyridine and its 1-oxide exist in the crystalline state in the lactam form.A quantitative estimate of the position of the tautomeric equilibrium of 4-hydroxy-1,5-naphthyridine as a function of the polarity of the solvent is given, and the tautomeric equilibrium constants and the percentages of the lactim form are calculated.The basicity constants of 4-chloro-, 4-methoxy-, 4-hydrazino-, 4-methylthio-, 4-acetamido-, and 4-amino-1,5-naphthyridines were measured.A comparison of the calculated and the experimental pKa data provides evidence in favor of the fact that the compounds are protonated at the N1 atom.A correlation of the basicity constants with the ? substituent constants is examined.

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1,404-Naphthyridine – Wikipedia,
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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, SDS of cas: 5423-54-1, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 5423-54-1, Name is 1,5-Naphthyridin-4-ol, molecular formula is C8H6N2O

SB-334867 has been an important ligand for the study of the orexin 1 (OX1) receptor due to its high OX1/OX2 selectivity and bioavailability. This ligand however, contains a 2-methylbenzoxazole ring system which is known to undergo hydrolysis, particularly under acidic or basic conditions. The possibility that SB-334867 would be susceptible to significant hydrolysis was evaluated in various formulations and in the solid state. SB-334867 was found to be unstable under conditions commonly employed to prepare stock solutions for in vitro and in vivo studies. In addition, and most alarmingly, the hydrochloride salt of SB-334867 was found to quantitatively decompose to an OX1-inactive product even in the solid state. These findings combine to suggest that studies using SB-334867 (and any other 2-methylbenzoxazole-containing compound) should be performed with great care to avoid the confounding effects of the rapid hydrolytic decomposition of this susceptible structure.

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1,398-Naphthyridine – Wikipedia,
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Electric Literature of 5423-54-1, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 5423-54-1, Name is 1,5-Naphthyridin-4-ol, molecular formula is C8H6N2O. In a Patent£¬once mentioned of 5423-54-1

3M INNOVATIVE PROPERTIES COMPANY

The invention provides various crystalline forms of 1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine ethanesulfonate, pharmaceutical compositions, methods of making, and methods of use.

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1,386-Naphthyridine – Wikipedia,
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Eisai Co., Ltd.

An anxiolytic drug of the invention comprises an orexin receptor antagonist, a pharmacologically acceptable salt thereof, or a solvate thereof as an active ingredient. A method for screening a compound having an anxiolytic action of the invention comprises a step of using orexin-A.

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1,392-Naphthyridine – Wikipedia,
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This communication reports SARs for the first orexin-1 receptor antagonist series of 1-aryl-3-quinolin-4-yl and 1-aryl-3-naphthyridin-4-yl ureas. One of these compounds, 31 (SB-334867), has excellent selectivity for the orexin-1 receptor, blood-brain barrier permeability and shows in vivo activity following ip dosing.

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1,400-Naphthyridine – Wikipedia,
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