Category: 53731-26-3

Aikawa, Kohsuke published the artcilePalladium-Catalyzed Negishi Cross-Coupling Reaction of Aryl Halides with (Difluoromethyl)zinc Reagent, Recommanded Product: 1-(Difluoromethyl)naphthalene, the publication is Organic Letters (2016), 18(15), 3690-3693, database is CAplus and MEDLINE.

The palladium-catalyzed Negishi cross-coupling reaction of aryl iodides I [R = CN-4, NO₂-4, CO₂Et-4, Cl-4, (Bu-t)-4, OMe-4, Ph-4, Me₂-3,5, CHOCHCHOCH-2,3, Me₃-2,4,6; X = I] and bromides I [R = NO₂-4, CO₂Et-4, (Bu-t)-4, CN-3; X = Br] with (difluoromethyl)zinc reagent bearing a diamine such as TMEDA is achieved to provide the difluoromethylated aromatic compounds II in good to excellent yields. The advantages of (difluoromethyl)zinc reagent are that (1) the derivatives, which possess different stability and reactivity, can be readily prepared via ligand screening and (2) transmetalation of a difluoromethyl group from the zinc reagent to palladium catalyst efficiently proceeds without an activator.

Organic Letters published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C11H8F2, Recommanded Product: 1-(Difluoromethyl)naphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Middleton, William J. published the artcileNew fluorinating reagents. Dialkylaminosulfur fluorides, Related Products of naphthyridine, the publication is Journal of Organic Chemistry (1975), 40(5), 574-8, database is CAplus.

Trifluorides R2NSF3 (I; R = Me, Et, Me2CH; or R2N = pyrrolidino) were prepared by the reaction of R2NSiMe3 with SF4 in FCCl3 at -78°; I reacted with R21NSiMe3 to give R2NSF2NR21 (II; R, R1 = Me, Et; or R12 = piperidino). I and II were used to fluorinate alcs., aldehydes, or ketones. E.g., I (R = Et) reacted with Me2CHCH2OH in diglyme at -50 to -78° to give 49% Me2CHCH2F and 21% Me3CF. EtCHO with I (R = Et) in FCCl3 at 25° gave 80% EtCHF2. Among ∼23 other compounds fluorinated were: cyclooctanol, BzH, 1-naphthaldehyde, and menthol.

Journal of Organic Chemistry published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C11H8F2, Related Products of naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Miao, Wenjun published the artcileIron-Catalyzed Difluoromethylation of Arylzincs with Difluoromethyl 2-Pyridyl Sulfone, Product Details of C11H8F2, the publication is Journal of the American Chemical Society (2018), 140(3), 880-883, database is CAplus and MEDLINE.

In the presence of Fe(acac)₃ and N,N,N’,N’-tetramethylethylenediamine, arylzinc reagents (in most cases generated in situ from aryl Grignard reagents) underwent difluoromethylation reactions with difluoromethyl 2-pyridinyl sulfone at -40° to ambient temperature to yield difluoromethylarenes. Reaction of a difluoropentenyl 2-pyridinyl sulfone with an in situ-generated diarylzinc reagent yielded an arylmethyldifluorocyclopentane, implying the involvement of radical species in the iron-catalyzed difluoromethylation; the reaction was inhibited by TEMPO, BHT, and 1,4-dinitrobenzene.

Journal of the American Chemical Society published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C11H8F2, Product Details of C11H8F2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Yoshida, Kunio published the artcileLaser-induced damage of multilayer coated optical components, Application of 1-(Difluoromethyl)naphthalene, the publication is Kaku Yugo Kenkyu (1992), 68(Suppl.), 227-33, database is CAplus.

A number of optics having high quality and high damage threshold were developed. The damage threshold of borosilicate crown glass was considerably improved. The surface roughness dependence of the laser-induced surface damage of optical glasses and the laser-induced damage of HR coating were found for the first time. These optical technologies meet the GEKKO XII Upgrade fluence requirements.

Kaku Yugo Kenkyu published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C17H20ClN3, Application of 1-(Difluoromethyl)naphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Zheng, Yu published the artcilePhosphonium Ylide-Mediated Programmable Fluorination to Access Mono- and Difluoromethylarenes, Application In Synthesis of 53731-26-3, the publication is Organic Letters, database is CAplus and MEDLINE.

Compounds bearing fluorinated moieties are pervasive in a wide range of pharmaceuticals and agrochems. The installation of fluorinated units is a persistently vital task in synthetic chem., where facile and manipulable assays are highly demanding. Herein, we establish a general and programmable fluorination strategy for the modular assembly of mono- and difluoromethylarenes through the controllable deprotonation and fluorination of phosphonium ylides. Moreover, the rational combination of the reaction sequence allows the rapid construction of diversified fluorine-containing arenes.

Organic Letters published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C23H20BN, Application In Synthesis of 53731-26-3.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

He, Guowen published the artcilePh₂S/selectfluor-promoted deoxydifluorination of aldehydes, COA of Formula: C11H8F2, the publication is Tetrahedron (2021), 131963, database is CAplus.

The installation of a HCF₂ group is a research area that has received increasing attention, and deoxydifluorination of aldehydes have served as an attractive protocol due to the wide availability of aldehydes. Herein a Ph₂S/selectfluor-promoted deoxydifluorination of aldehydes under mild conditions is described. Compared with previous deoxydifluorination methods, which usually use hazardous reagents such as SF₄, DAST and deoxo-fluor, this protocol is quite attractive because of the safe and convenient operations, and the use of easily available reagents.

Tetrahedron published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C11H8F2, COA of Formula: C11H8F2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Sap, Jeroen B. I. published the artcileSynthesis of ¹⁸F-difluoromethylarenes using arylboronic acids, ethyl bromofluoroacetate and [¹⁸F]fluoride, Recommanded Product: 1-(Difluoromethyl)naphthalene, the publication is Chemical Science (2019), 10(11), 3237-3241, database is CAplus and MEDLINE.

Herein, the radiosynthesis of ¹⁸F-difluoromethylarenes RCHF¹⁸F (R = 4-C₂H₅, 4-OC₆H₅, 3,5-CH₃, etc.) via the assembly of three components, a boron reagent, Et bromofluoroacetate, and cyclotron-produced non-carrier added [¹⁸F]fluoride was reported. The two key steps are a copper-catalyzed cross-coupling reaction, and a Mn-mediated ¹⁸F-fluorodecarboxylation.

Chemical Science published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C11H8F2, Recommanded Product: 1-(Difluoromethyl)naphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Fuchibe, Kohei published the artcileSynthesis of (difluoromethyl)naphthalenes using the ring construction strategy: C-C bond formation on the central carbon of 1,1-difluoroallenes via Pd-catalyzed insertion, Application In Synthesis of 53731-26-3, the publication is Organic & Biomolecular Chemistry (2019), 17(20), 5047-5054, database is CAplus and MEDLINE.

The insertion of 1,1-difluoroallenes was carried out to form a C-C bond exclusively on their central carbon. O-Bromophenyl-bearing 1,1-difluoroallenes underwent intramol. insertion in the presence of a palladium catalyst. Regioselective C-C bond formation occurred to form a six-membered carbocycle, leading to pharmaceutically and agrochem. promising difluoromethylated naphthalenes.

Organic & Biomolecular Chemistry published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C11H8F2, Application In Synthesis of 53731-26-3.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Verhoog, Stefan published the artcileSilver-Mediated ¹⁸F-Labeling of Aryl-CF₃ and Aryl-CHF₂ with ¹⁸F-Fluoride, Formula: C11H8F2, the publication is Synlett (2016), 27(1), 25-28, database is CAplus.

We report the synthesis of [¹⁸F]arylCF₃ and [¹⁸F]arylCHF₂ derivatives from arylCF₂Br and arylCHFCl precursors applying a silver-mediated halogen exchange with [¹⁸F]fluoride. In the absence of Ag(I)OTf, no reaction takes place at room temperature for both classes of substrates; this result demonstrates the beneficial role of silver(I) as a means to induce ¹⁸F-incorporation under very mild conditions.

Synlett published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C9H9BrO2, Formula: C11H8F2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Zou, Zhenlei published the artcileElectrochemical-Promoted Nickel-Catalyzed Oxidative Fluoroalkylation of Aryl Iodides, Recommanded Product: 1-(Difluoromethyl)naphthalene, the publication is Organic Letters (2021), 23(21), 8252-8256, database is CAplus and MEDLINE.

This work describes a general strategy for metal-catalyzed cross-coupling of fluoroalkyl radicals with aryl halides ArX (Ar = biphenyl-4-yl, benzothiophen-3-yl, benzodioxol-5-yl, etc.; X = Br, I) under electrochem. conditions. The contradiction between anodic oxidation of fluoroalkyl sulfinates NaSO₂CF₂H, NaSO₂CH₂F and cathodic reduction of low-valent nickel catalysts can be well addressed by paired electrolysis, allowing for direct introduction of fluorinated functionalities into aromatic systems.

Organic Letters published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C3H8N2S, Recommanded Product: 1-(Difluoromethyl)naphthalene.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem