Syntheses and properties of 2,3-dibromo- and 2,3-dichloro-1,8-naphthyridines was written by Czuba, Wladyslaw;Wozniak, Marian. And the article was included in Roczniki Chemii in 1973.Safety of 2-Bromo-3-chloro-1,8-naphthyridine This article mentions the following:
Naphthyridinol I with KClO3 in concentrated HCl at 50° yielded 73% II, which heated at 125° with POBr3 gave 80% III. Similarly, II refluxed with POCl3 gave 98% IV. III and p-MeC6H4SO2-NHNH2 refluxed 24 hr in CHCl3 yielded 82% V.HBr; a similar reaction attempted with IV failed. V.HBr refluxed with aqueous Na2CO3 gave 28% VI. Analogs of II, IV, V, and VI with Br in place of Cl were prepared similarly. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-chloro-1,8-naphthyridine (cas: 52626-32-1Safety of 2-Bromo-3-chloro-1,8-naphthyridine).
2-Bromo-3-chloro-1,8-naphthyridine (cas: 52626-32-1) belongs to naphthyridine derivatives. Six naphthyridine isomers are white solids with a surprisingly wide span of melting points: 1,6-Naphthyridine’s is the lowest at <40 ºC; 2,6-naphthyridine’s is the highest at 114–115 ºC. Halogen atoms attached to the naphthyridine moiety can be easily replaced by other nucleophiles such as alkoxides and amines.Safety of 2-Bromo-3-chloro-1,8-naphthyridine
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem