Category: 215523-34-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.215523-34-5,1,8-Naphthyridine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a suspension of 1,8-naphthyridine-2-carboxylic acid (2?g, 0.011?mol) in dry benzene (50?mL), was added oxalyl chloride (1.4?mL, 0.017?mol) drop wisely at 0?C. Then few drops of DMF were added and the reaction began immediately. It was then slowly broug

215523-34-5, The synthetic route of 215523-34-5 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.215523-34-5,1,8-Naphthyridine-2-carboxylic acid,as a common compound, the synthetic route is as follows.,215523-34-5

General procedure: To the resin 13 (560 mg) in DMF (2.5 mL) were added a solutionof the appropriate Fmoc-protected amino acid (see Tables 1-3)(0.3 M), PyBOP (0.3 M) and HOBt (0.3 M) in dry DMF (4.2 mL). Thesuspensions were stirred for 3 min and then DIPEA (0.6 M) wasadded. The suspensions were stirred for 3 h under an argon atmosphereat rt. The resins were washed successively with DCM(150 mL), MeOH (120 mL), DCM (75 mL) and dried overnight undervacuum to give resins 14, each bearing an appropriate Fmoc-protectedamino acid. To the resins 14 (161 mg, 0.13 mmol) wereadded a solution of piperidine (20%, v/v) in DCM (2.1 mL) and themixtures were stirred for 1 h at rt. After filtration, the resins werewashed successively with DCM (50 mL), MeOH (45 mL), DCM(25 mL) and dried under vacuum to give resins 15. Portions(65 mg) of resins 15 were placed in reactor wells (12 mL) of anautomated synthesizer reaction block (40-well format) (AdvancedChemTech). To each well was added a solution of appropriate carboxylicacid (see Tables 1-3) (0.3 M), PyBOP (0.3 M) and HOBt 6-Cl(0.3 M) and DIPEA (0.6 M) in dry DMF (2 mL). The suspensionswere vortexed at 300 rpm over a period of 5 h under an argonatmosphere. The wells were then filtered to remove the reactivesolution from the resins 16 and washed successively with THF,DCM, MeOH and DCM.

215523-34-5 1,8-Naphthyridine-2-carboxylic acid 735156, anaphthyridine compound, is more and more widely used in various fields.

Reference£º
Article; Talbot, Amelie; Maltais, Rene; Kenmogne, Lucie Carolle; Roy, Jenny; Poirier, Donald; Steroids; vol. 107; (2016); p. 55 – 64;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

215523-34-5, 1,8-Naphthyridine-2-carboxylic acid is a naphthyridine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

215523-34-5, General procedure: To the resin 13 (560 mg) in DMF (2.5 mL) were added a solutionof the appropriate Fmoc-protected amino acid (see Tables 1-3)(0.3 M), PyBOP (0.3 M) and HOBt (0.3 M) in dry DMF (4.2 mL). Thesuspensions were stirred for 3 min and then DIPEA (0.6 M) wasadded. The suspensions were stirred for 3 h under an argon atmosphereat rt. The resins were washed successively with DCM(150 mL), MeOH (120 mL), DCM (75 mL) and dried overnight undervacuum to give resins 14, each bearing an appropriate Fmoc-protectedamino acid. To the resins 14 (161 mg, 0.13 mmol) wereadded a solution of piperidine (20%, v/v) in DCM (2.1 mL) and themixtures were stirred for 1 h at rt. After filtration, the resins werewashed successively with DCM (50 mL), MeOH (45 mL), DCM(25 mL) and dried under vacuum to give resins 15. Portions(65 mg) of resins 15 were placed in reactor wells (12 mL) of anautomated synthesizer reaction block (40-well format) (AdvancedChemTech). To each well was added a solution of appropriate carboxylicacid (see Tables 1-3) (0.3 M), PyBOP (0.3 M) and HOBt 6-Cl(0.3 M) and DIPEA (0.6 M) in dry DMF (2 mL). The suspensionswere vortexed at 300 rpm over a period of 5 h under an argonatmosphere. The wells were then filtered to remove the reactivesolution from the resins 16 and washed successively with THF,DCM, MeOH and DCM.

The synthetic route of 215523-34-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Talbot, Amelie; Maltais, Rene; Kenmogne, Lucie Carolle; Roy, Jenny; Poirier, Donald; Steroids; vol. 107; (2016); p. 55 – 64;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.215523-34-5,1,8-Naphthyridine-2-carboxylic acid,as a common compound, the synthetic route is as follows.,215523-34-5

600 mg (3.44 mmol) of 1,8-naphthyridine-2-carboxylic acid and 0.754 ml (10.3 mmol) of thionyl chloride were stirred in 15 ml of methanol at 60 C. for 6 h. The mixture was freed of the solvent under reduced pressure. Methyl tert-butyl ether was added to the residue and the mixture was freed of the solvent under reduced pressure. log P (neutral): 0.77; MH+: 189; 1H-NMR (400 MHz, CD3CN) delta ppm: 4.00 (s, 3H), 7.84 (dd, 1H), 8.27 (d, 1H), 8.70 (dd, 1H), 8.76 (d, 1H), 9.28 (m, 1H).

The synthetic route of 215523-34-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER CROPSCIENCE AKTIENGESELLSCHAFT; FISCHER, Ruediger; HAGER, Dominik; HOFFMEISTER, Laura; KAUSCH-BUSIES, Nina; WILCKE, David; WILLOT, Matthieu; GOeRGENS, Urich; ILG, Kerstin; MOSRIN, Marc; PORTZ, Daniela; TURBERG, Andreas; US2018/305353; (2018); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

215523-34-5, 1,8-Naphthyridine-2-carboxylic acid is a naphthyridine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,215523-34-5

PyBOP (132 mg, 254 muiotaetaomicronIota) was added to a mixture of 1 ,8-naphthyridine-2-carboxylic acid (40.2 mg, 231 muiotaetaomicronIota), 8-amino-2-(2-chloro-4,5-difluorophenyl)-2-azaspiro[4.5]decan-1 -one (isomer 1 , Intermediate I45 ) (80.0 mg, 254 muiotaetaomicronIota) and N,N-diisopropylethylamine (160 muIota, 920 muiotaetaomicronIota) in DMF (2.3 ml) and the mixture was stirred for 2 h at room temperature. For work-up, water (45 ml) and methanol (2 ml) were added and the mixtre was stirred over night. The precipitate was collected by filtration, washed with water and dried to give the title compound 87.0 mg (79 % yield). LC-MS (Method 1 ): Rt= 1.08 min; MS (ESIpos): m/z = 471 [M+H]+1H-NMR (400 MHz, DMSO-d6) delta [ppm]: 0.932 (1.28), 0.949 (1.24), 1.231 (1.28), 1.352 (0.85), 1.591 (0.43), 1.634 (0.73), 1.657 (3.54), 1.665 (3.07), 1.689 (16.00), 1.696 (15.91), 1.732 (4.05), 1.742 (3.41), 1.761 (3.46), 1.772 (3.11), 1.791 (1.62), 1.801 (1.37), 1.855 (5.29), 1.877 (3.07), 1.886 (2.69), 2.069 (0.43), 2.155 (7.04), 2.172 (13.78), 2.190 (7.51), 2.337 (0.81), 2.518 (9.26), 2.523 (6.53), 2.674 (1.79), 2.679 (0.81), 2.888 (0.47), 3.612 (0.51), 3.639 (7.59), 3.656 (13.87), 3.674 (7.34), 3.871 (0.73), 3.897 (1.75), 3.908 (1.66), 3.919 (1.75), 3.946 (0.73), 7.697 (5.21), 7.717 (5.72), 7.724 (5.59), 7.732 (9.13), 7.743 (11.05), 7.753 (8.02), 7.763 (9.30), 7.863 (5.38), 7.884 (5.63), 7.889 (5.80), 7.910 (5.63), 8.264 (15.15), 8.285 (15.66), 8.580 (7.55), 8.586 (7.89), 8.601 (7.64), 8.606 (7.17), 8.680 (15.27), 8.701 (13.82), 8.822 (6.10), 8.844 (5.89), 9.197 (8.96), 9.202 (9.17), 9.208 (8.41), 9.212 (7.94)

As the paragraph descriping shows that 215523-34-5 is playing an increasingly important role.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; EIS, Knut; WAGNER, Sarah; SUeLZLE, Detlev; VON NUSSBAUM, Franz; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philipp; (248 pag.)WO2018/78005; (2018); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.215523-34-5,1,8-Naphthyridine-2-carboxylic acid,as a common compound, the synthetic route is as follows.,215523-34-5

14.00 mmol of corresponding amino derivative and 10.00 mmol of carboxylic acid, 11.00 mmol of 1-hydroxybenzotriazole and 11.10 mmol of N’-(3-dimethylaminopropyl)-N-ethylcarbodiimid hydrochlorid in 120 cm3 N,N dimethylformamide was stirred overnight at room temperature. Then 1000 g of crashed ice was added and stirred further one hour. The precipitate was filtered off, washed with saturated NaHCO3 solution, water and dried at room temperature. The crude material was refluxed in ethylalcohol for 10 minutes, cooled back and filtered off.

As the paragraph descriping shows that 215523-34-5 is playing an increasingly important role.

Reference£º
Patent; Klebl, Bert; Baumann, Matthias; Hoppe, Edmund; Brehmer, Dirk; Daub, Henrik; Keri, Gyorgy; Varga, Zoltan; Marosfalvi, Jeno; Orfi, Laszlo; US2008/187575; (2008); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem