Category: 15944-34-0

It is a common heterocyclic compound, the naphthyridine compound, 7-Chloro-1,8-naphthyridin-2-ol, cas is 15944-34-0 its synthesis route is as follows.

Preparation B 7-methoxy-1H-[1,8]naphthyridin-2-one To a solution of 7-chloro-1H-[1,8]naphthyridin-2-one (prepared as described in J. Org. Chem. (1990), 55, 4744; 5.36 g, 29.68 mmol) in MeOH (98 mL) was added NaOMe (25 wt % in MeOH, 161 mL). The resulting solution was stirred at reflux for 15 h. The solvent was removed in vacuo. Water (100 mL) and EA (80 mL) were added. The phases were separated and the aq. layer was extracted with EA (8*80 mL). The combined org. layers were washed with brine (50 mL), dried over MgSO4, filtered and evaporated under reduced pressure. The title compound was obtained as a beige solid (5.22 g, 100% yield). 1H NMR (d6DMSO) delta: 11.96 (s, 1H); 7.96 (d, J=8.5 Hz, 1H); 7.81 (d, J=9.4 Hz, 1H); 6.63 (d, J=8.5 Hz, 1H); 6.34 (d, J=9.4 Hz, 1H); 3.90 (s, 3H).

15944-34-0, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,15944-34-0 ,7-Chloro-1,8-naphthyridin-2-ol, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Actelion Pharmaceuticals Ltd.; US2012/40989; (2012); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

It is a common heterocyclic compound, the naphthyridine compound, 7-Chloro-1,8-naphthyridin-2-ol, cas is 15944-34-0 its synthesis route is as follows.

EXAMPLESEXAMPLE l7-(4-Hydroxy-butoxy)-lH-[l,8]naphthyridin-2-one; To 1 liter (L) of n-methylpyrrolidinone was added 60% sodium hydride suspension (83.6g, 2.09moles). With external cooling to maintain 50C, 1,4-butanediol (3.39 moles) was added dropwise, causing offgassing. The mixture was stirred for 15 minutes at 60C, followed by addition of 7-Chloro-lH-[l,8]naphthyridin-2-one (Journal of Organic Chemistry, 55(15), 4744-50; 1990, 146g, 0.813 moles) while stirring at 680C for 20 hours (h). To the mixture was added 5 liters of acetonitrile followed by filtration of a solid which was washed with a 50:50 mixture of acetonitrile and tetrahydrofuran. The solid was resuspended in 3 liters of tetrahydrofuran, to which was EPO added 3N HCl in methanol (290ml, 0.870 moles). After heating for 1 hour at 6O0C, the mixture was filtered thru celite, washed with 1 liter of tetrahydrofuran and concentrated to 500ml in volume. To the residue was added 1.5 liters of tetrahydrofuran, 1Og Darco activated charcoal, and 100ml Magnesol. After stirring at 40C for 30 minutes (min.), the mixture was filtered and washed with tetrahydrofuran and concentrated to 500ml in volume. To this residue was added 1 liter of acetonitrile followed by concentration of the mixture to 1 liter in volume. The resulting solid precipitate was filtered, washed with acetonitrile and ether, and dried at 50C giving 7-(4-Hydroxy-butoxy)-lH- [l,8]naphthyridin-2-one, 101g, (53% yield).

15944-34-0, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,15944-34-0 ,7-Chloro-1,8-naphthyridin-2-ol, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; WARNER-LAMBERT COMPANY LLC; WO2006/90272; (2006); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem

Reference of 15944-34-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.15944-34-0, Name is 7-Chloro-1,8-naphthyridin-2-ol, molecular formula is C8H5ClN2O. In a Patent£¬once mentioned of 15944-34-0

WARNER-LAMBERT COMPANY LLC

Disclosed are piperazine derivatives, their manufacture and use as inhibitors of renin. Formula (I):

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 15944-34-0

Reference£º
1,518-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N512 – PubChem

15944-34-0, Name is 7-Chloro-1,8-naphthyridin-2-ol, belongs to naphthyridine compound, is a common compound. Product Details of 15944-34-0In an article, once mentioned the new application about 15944-34-0.

REDX PHARMA PLC; COOPER, Ian; LYONS, Amanda; ORR, David; KIRKHAM, James; BLADES, Kevin

This invention relates to antibacterial drug compounds containing a bicyclic core, typically a bicycle in which one of the rings is an oxazolidinone. It also relates to pharmaceutical formulations of antibacterial drug compounds. It also relates to uses of the compounds in treating bacterial infections and in methods of treating bacterial infections.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 15944-34-0

Reference£º
1,511-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N505 – PubChem

15944-34-0, Name is 7-Chloro-1,8-naphthyridin-2-ol, belongs to naphthyridine compound, is a common compound. category: naphthyridineIn an article, once mentioned the new application about 15944-34-0.

AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.; OMBRATO, Rosella; MAGARO’, Gabriele; GAROFALO, Barbara; FURLOTTI, Guido; MANGANO, Giorgina; CAPEZZONE DE JOANNON, Alessandra

The present invention relates to novel antibacterial compounds, pharmaceutical compositions containing them and their use as antimicrobials.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 15944-34-0

Reference£º
1,519-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N513 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Formula: C8H5ClN2O. Introducing a new discovery about 15944-34-0, Name is 7-Chloro-1,8-naphthyridin-2-ol

ASTRAZENECA AB; ASTRAZENECA UK LIMITED

The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Formula: C8H5ClN2O, you can also check out more blogs about15944-34-0

Reference£º
1,508-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N502 – PubChem

Electric Literature of 15944-34-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 15944-34-0, 7-Chloro-1,8-naphthyridin-2-ol, introducing its new discovery.

A new three-step procedure for pyridine annulation is described and illustrated with efficient syntheses of various 1,6-, 1,7-, and 1,8-naphthyridin-2-ones as well as 6-chloroquinolin-2-one.The regiospecific ortho metalation and subsequent formylation of 2-, 3-, or 4-(pivaloylamino)pyridines provides the corresponding protected ortho aminopyridinecarboxaldehydes as key intermediates in this procedure.After condensation of these aldehydes with tert-butyl lithioacetate the resulting beta-hydroxy esters are treated with refluxing aqueous HCl to generate the naphthyridine system in excellent yield.Naphthyridines with diverse substitution patterns in eighter of the pyridine rings are available by appropriate modification of the overall pyridine annulation sequence.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 15944-34-0. In my other articles, you can also check out more blogs about 15944-34-0

Reference£º
1,522-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N516 – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 7-Chloro-1,8-naphthyridin-2-ol, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 15944-34-0, name is 7-Chloro-1,8-naphthyridin-2-ol. In an article£¬Which mentioned a new discovery about 15944-34-0

WARNER-LAMBERT COMPANY LLC

Compounds of formula (I) are disclosed. A of formula 1 is-(CH2 )mCO-or-(CH2)mCOH-, wherein m is an integer from 2 to 5 and wherein one or two of the carbon atoms can be substituted as described in the specification. G, D, Z, Q, X, Y, R 1, and R4 through R7 of formula 1 are defined in the specification. Also provided are descriptions of processes for preparing compounds of formula 1, intermediates used in making the same, and pharmaceutical compositions containing such compounds and their use in the treatment of central nervous system disorders and other disorders.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 15944-34-0, help many people in the next few years.Recommanded Product: 7-Chloro-1,8-naphthyridin-2-ol

Reference£º
1,516-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N510 – PubChem

15944-34-0, Name is 7-Chloro-1,8-naphthyridin-2-ol, belongs to naphthyridine compound, is a common compound. category: naphthyridineIn an article, once mentioned the new application about 15944-34-0.

Novel non-fluoroquinolone inhibitors of bacterial type II topoisomerases (DNA gyrase and topoisomerase IV) are of interest for the development of new antibacterial agents that are not impacted by target-mediated cross-resistance with fluoroquinolones. Aminopiperidines that have a bicyclic aromatic moiety linked through a carbon to an ethyl bridge, such as 1, generally show potent broad-spectrum antibacterial activity, including quinolone-resistant isolates, but suffer from potent hERG inhibition (IC50= 3 M for 1). We now disclose the finding that new analogues of 1 with an N-linked cyclic amide moiety attached to the ethyl bridge, such as 24m, retain the broad-spectrum antibacterial activity of 1 but show significantly less hERG inhibition (IC 50= 31 M for 24m) and higher free fraction than 1. One optimized analogue, compound 24l, showed moderate clearance in the dog and promising efficacy against Staphylococcus aureus in a mouse thigh infection model.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 15944-34-0

Reference£º
1,521-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N515 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, category: naphthyridine, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 15944-34-0, Name is 7-Chloro-1,8-naphthyridin-2-ol, molecular formula is C8H5ClN2O

SUNOVION PHARMACEUTICALS INC.; JONES, Phillip, G.; LEW, Robert; SPEAR, Kerry, L.; XIE, Linghong

Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and neurological disorders, including, but not limited to, e.g., psychosis, schizophrenia, depression, movement disorders, and Parkinson’s disease.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, category: naphthyridine, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 15944-34-0

Reference£º
1,517-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N511 – PubChem