Category: 1588-83-6

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 1588-83-6, Name is 4-Amino-3-nitrobenzoic acid, SMILES is C1=C([N+]([O-])=O)C(=CC=C1C(=O)O)N, in an article , author is Feng Lian-shun, once mentioned of 1588-83-6, HPLC of Formula: C7H6N2O4.

New Way to Synthesize DW286-a Novel Fluoronaphthyridone Antibacterial Agent

A new route for the synthesis of DW286, 7-[3-(aminomethyl)-4-(methoxyimino)-3-methyltetrahydro-1H-1-pyrrolyL]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid hydrochloric acid salt, is described. In the presence of benzadehyde, DW286 was prepared by the direct condensation of 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid with new pyrrolidine derivative 7 which could be obtained by routine reactions.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Nicolay, Amelie, once mentioned the application of 1588-83-6, Name is 4-Amino-3-nitrobenzoic acid, molecular formula is C7H6N2O4, molecular weight is 182.1335, MDL number is MFCD00017009, category is naphthyridines. Now introduce a scientific discovery about this category, Application In Synthesis of 4-Amino-3-nitrobenzoic acid.

Selective Synthesis of a Series of Isostructural (MCuI)-Cu-II Heterobimetallic Complexes Spontaneously Assembled by an Unsymmetrical Naphthyridine-Based Ligand

Metal-metal cooperation is integral to the function of many enzymes and materials, and model complexes hold enormous potential for providing insights into the capabilities of analogous multimetallic cores. However, the selective synthesis of heterobimetallic complexes still presents a significant challenge, especially for systems that hold the metals in close proximity and feature open or reactive coordination sites for both metals. To address this issue, a rigid, naphthyridine-based dinucleating ligand featuring distinct binding environments was synthesized. This ligand enables the selective synthesis of a series of (MCuI)-Cu-II bimetallic complexes (M=Mn, Fe, Co, Ni, Cu, Zn), in which each metal center exclusively occupies its preferred binding pocket, from simple chloride salts. The precision of this selectivity is evident from cyclic voltammetry, ESI-MS and anomalous X-ray diffraction measurements.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

In an article, author is Chaitanya, Muggu V. S. R. K., once mentioned the application of 1588-83-6, Application In Synthesis of 4-Amino-3-nitrobenzoic acid, Name is 4-Amino-3-nitrobenzoic acid, molecular formula is C7H6N2O4, molecular weight is 182.1335, MDL number is MFCD00017009, category is naphthyridines. Now introduce a scientific discovery about this category.

A simple and efficient synthesis of novel naphthyridine-1-H-pyrazole-4-carboxylic acid esters/carbaldehydes using Vilsmeier-Haack reagent

The reaction of hydrazide 4 with beta-keto esters 5 gave hydrazones 6. Cyclization of 6 with Vilsmeier-Haack reagent (DMF-POCl3) for 20 min at room temperature gave 1-(4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carbonyl)-1H-pyrazole-4-carboxylic acid ethyl esters 7. The treatment of 4 with substituted acetophenones 8 yielded the corresponding hydrazones 9 of substituted acetophenones. The treatment of 9 with Vilsmeier-Haack reagent (DMF-POCl3) for 30 min at room temperature gave product 10, the reaction of which with (diacetoxyiodo) benzene in ethanol at room temperature for 12 h in the presence of molecular iodine furnished 7.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, Computed Properties of C7H6N2O4, begins with the direct observation of nature¡ª in this case, of matter.1588-83-6, Name is 4-Amino-3-nitrobenzoic acid, SMILES is C1=C([N+]([O-])=O)C(=CC=C1C(=O)O)N, belongs to naphthyridines compound. In a document, author is Park, T, introduce the new discover.

A quadruply hydrogen bonded heterocomplex displaying high-fidelity recognition

An exceptionally strong quadruply hydrogen-bonded complex is formed between 2,7-diamido-1,8-naphthyridine 3 (DAN) and the butylurea of guanosine 6 (UG) in chloroform. The UG unit can be prepared in four steps from guanosine on a 10 g scale in excellent yields without chromatographic purification. The association constant (K-assoc approximate to 5 x 10(7) m(-1)) for the UG(.)DAN complex determined by fluorescence energy transfer from the naphthyridine unit of 3 to coumarin 343 covalently linked UG (18) is among the highest reported for a neutral DNA base-pair analogue. The weak self-association of DAN (K-dimer < 10 m(-1)) and UG (K-dimer ca. 200-300 m(-1)) means that the UG-DAN complex forms with unparalleled fidelity. Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 1588-83-6. Computed Properties of C7H6N2O4.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, COA of Formula: C7H6N2O4, begins with the direct observation of nature¡ª in this case, of matter.1588-83-6, Name is 4-Amino-3-nitrobenzoic acid, SMILES is C1=C([N+]([O-])=O)C(=CC=C1C(=O)O)N, belongs to naphthyridines compound. In a document, author is Mogilaiah, K., introduce the new discover.

Claisen-Schmidt condensation under solvent-free conditions

Claisen-Schmidt condensation of 2-(4-acetyl-phenylamino)-3-(4-chlorophenyl)-1,8-naphthyridine 3 with various aromatic aldehydes under solvent-free conditions to prepare alpha-beta-unsaturated ketones 4 using solid NaOH as catalyst has been described. The reaction proceeds efficiently at room temperature in high yields and in a state of excellent purity.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 1588-83-6. COA of Formula: C7H6N2O4.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1588-83-6, Name is 4-Amino-3-nitrobenzoic acid, molecular formula is C7H6N2O4. In an article, author is Boskovic, Miladin,once mentioned of 1588-83-6, Application In Synthesis of 4-Amino-3-nitrobenzoic acid.

Potential Antitumor Effect of Newly Synthesized Dinuclear1,5-Naphthyridine-Bridging Palladium(II) Complexes

Five new dinuclear palladium(II) complexes with general formula, [{Pt(L)Cl}(2)(mu-1,5-nphe)](NO3)(2)(L is ethylenediamine (en), (+/-)-1,2-propylenediamine (1,2-pn),trans-(+/-)-1,2-diaminocyclohexane (dach), 1,3-propylenediamine (1,3-pd), (+/-)-1,3-pentanediamine (1,3-pnd) and 1,5-nphe is bridging 1,5-naphthyridine ligand) were synthesised and spectroscopically characterized.In vitrocytotoxic activity of these complexes was evaluated against mouse mammary carcinoma (4T1), colon (CT26), lung cancer cells (LLC1) and melanoma (B16-F10) as well as human lung adenocarcinoma (A549), mammary carcinoma (MDA-MB-468), and colon cancer (HCT 116). The investigated complexes reduced viability of tumor cells in dose dependent manner. Dinuclear Pd(II) complexes act less cytotoxic toward tumor cells, compare to cisplatin, but also have greater selectivity toward mesenchymal stem cells. The potential mechanism of cell death of tumor cells treated with palladium(II) 1,5-naphthyridine dinuclear complexes is enhanced apoptosis, facilitated by down-regulation of anti-apoptotic Bcl-2 and up-regulation of pro-apoptotic Caspase-3.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Kaur, Maninder, once mentioned the application of 1588-83-6, Name is 4-Amino-3-nitrobenzoic acid, molecular formula is C7H6N2O4, molecular weight is 182.1335, MDL number is MFCD00017009, category is naphthyridines. Now introduce a scientific discovery about this category, COA of Formula: C7H6N2O4.

Exploring the Role of Water Molecules for Docking and Receptor Guided 3D-QSAR Analysis of Naphthyridine Derivatives as Spleen Tyrosine Kinase (Syk) Inhibitors

In the present study, 3D-QSAR analysis was performed utilizing docking based alignment of [1,6]-naphthyridine derivatives as Syk enzyme inhibitors. The role of the water molecules was explored for the docking based alignment that revealed two conserved water molecules important for proper orientation and alignment of naphthyridine inhibitors in the active site of Syk enzyme. The QSAR model was selected having highest value of Q(2) (0.624) and Pearson-r (0.862). The selected model also displayed the highest values of R-2 (0.978) and F-value (184.5) and the lowest SD (0.862). The contour plots developed on the basis of the best model helped to reveal the essential structural features of naphthyridines derivatives responsible for inhibition of Syk enzyme. The generated model and information revealed from it was utilized to design and predict new congeneric molecules that can be used as potential therapeutic agents.

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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 1588-83-6, Name is 4-Amino-3-nitrobenzoic acid, SMILES is C1=C([N+]([O-])=O)C(=CC=C1C(=O)O)N, belongs to naphthyridines compound. In a document, author is Huang, Shengdian, introduce the new discover, Safety of 4-Amino-3-nitrobenzoic acid.

Design and synthesis of imidazo[1,2-alpha][1,8]naphthyridine derivatives as anti-HCV agents via direct C-H arylation

RO8191 represents a newly identified small-molecule IFN-alpha-substitute, which displays potent anti-HCV activity. In this communication, we reported the design and synthesis of two series of imidazo[1,2-alpha][1,8]naphthyridine derivatives, as RO8191 analogues, via a direct C-H arylation approach. Notably, by adjusting the reaction conditions, we could achieve the two series of analogues via regioselective single-and double-arylations, respectively. The anti-HCV activities of the synthesized compounds were evaluated within the HCV cell culture system, and the preliminary results showed that some of them displayed promising anti-HCV activities.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1588-83-6 is helpful to your research. Safety of 4-Amino-3-nitrobenzoic acid.

Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem