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An efficient NH4I-mediated intermolecular annulation of methyl N-heteroaromatics with amines/amino acids was developed by virtue of anodic oxidation, providing a variety of functionalized imidazo-fused N-heterocycles with good to excellent yields. The practicality of this protocol was demonstrated by the readily available starting materials, broad substrate scope, water tolerance, scalability, and the diverse transformations of the electrolysis product.

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1,366-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N360 – PubChem

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Morphic Therapeutic, Inc.; HARRISON, Bryce, A.; DOWLING, James, E.; BURSAVICH, Matthew, G.; TROAST, Dawn, M.; LIPPA, Blaise, S.; ROGERS, Bruce, N.; HAHN, Kristopher, N.; ZHONG, Cheng; QIAO, Qi; LIN, Fu-Yang; SOSA, Brian; GERASYUTO, Aleksey, I.; BORTOLATO, Andrea; SVENSSON, Mats, A.; HICKEY, Eugene; KONZE, Kyle, D.; DAY, Tyler; KIM, Byungchan

Disclosed are small molecule inhibitors of alphavbeta6 integrin, and methods of using them to treat a number of diseases and conditions.

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. COA of Formula: C9H8N2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1569-16-0, name is 2-Methyl[1,8]-Naphthyridine. In an article£¬Which mentioned a new discovery about 1569-16-0

GLAXO GROUP LIMITED

Naphthalene, quinoline, quinoxaline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.

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Oxygenation of 1,5-cyclooctadiene (COD) is achieved on an iridium center using water as a reagent. A hydrogen-bonding interaction with an unbound nitrogen atom of the naphthyridine-based ligand architecture promotes nucleophilic attack of water to the metal-bound COD. Irida-oxetane and oxo-irida-allyl compounds are isolated, products which are normally accessed from reactions with H2O2 or O2. DFT studies support a ligand-assisted water activation mechanism.

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Friedlander condensation of 2-aminonicotinaldehyde (I) with substituted benzalacetones (II) gives the corresponding 2-styryl-1,8-naphthyridines (III) in the presence of ethanol containing a catalytic amount of 20percent aq.KOH.The antimicrobial activity of the products against various bacteria and fungi has been evaluated.

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The pyrrolo<2.1-f>naphthyridine, pyrrolo<1,2-a><1,8>– and <1,5>naphthyridines along with their corresponding 2,3- and 1,2-dihydrocompounds are synthesized from naphthyridinium dicyanomethylides and dimethyl acetylenedicarboxylate.

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1,340-Naphthyridine – Wikipedia,
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GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ANDERSON, Niall Andrew; FALLON, Brendan John; PRITCHARD, John Martin

A compound of formula (I) or a salt thereof (I) wherein R1 represents a hydrogen atom, a methyl group or a ethyl group R2 represents a hydrogen atom or a fluorine atom R3 represents a hydrogen atom, a methyl group or an ethyl group.

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1,306-Naphthyridine – Wikipedia,
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Synthetic Route of 1569-16-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 1569-16-0, 2-Methyl[1,8]-Naphthyridine, introducing its new discovery.

SCIFLUOR LIFE SCIENCES, LLC; Askew, Ben C.; Heidebrecht, Richard W.; Furuya, Takeru; Duggan, Mark E.

The invention relates to fluorinated compounds and their use as integrin receptor antagonists. Novel fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives and pharmaceutically acceptable salts or solvates thereof and their use are described.

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1,308-Naphthyridine – Wikipedia,
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A palladium-catalyzed benzylic sp3 direct arylation of electron-deficient heterocycles is reported. The method described enables the introduction of electron-rich and -poor aromatics at the benzylic position of heterocycles without the need for preactivation or the use of directing groups.

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1,339-Naphthyridine – Wikipedia,
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1569-16-0, Name is 2-Methyl[1,8]-Naphthyridine, belongs to naphthyridine compound, is a common compound. Product Details of 1569-16-0In an article, once mentioned the new application about 1569-16-0.

A diastereoselective synthesis of (S)-3-(3-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl)-4-((R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic acid (1), a potential therapeutic agent for the treatment of Idiopathic Pulmonary Fibrosis, which is currently undergoing Phase I clinical trials is reported. The key steps in the synthesis involved alkylation of 2-methylnaphthyridine with (R)-N-Boc-3-(iodomethyl)-pyrrolidine, and an asymmetric Rh-catalysed addition of an arylboronic acid to a 4-(N-pyrrolidinyl)crotonate ester. The overall yield of the seven linear step synthesis was 8% and the product was obtained in >99.5% ee proceeding with 80% de. The absolute configuration of 1 was established by an alternative asymmetric synthesis involving alkylation of an arylacetic acid using Evans oxazolidinone chemistry, acylation using the resulting 2-arylsuccinic acid, and reduction. The absolute configuration of the benzylic asymmetric centre was established as (S).

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1,338-Naphthyridine – Wikipedia,
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