Category: 116-63-2

Xiao, Min published the artcileSynthesis of 2-borono-benzaldehyde-(2′-hydroxyl-4′-sulfonate) naphthalene hydrazone and recognition of Pb²⁺, Formula: C10H9NO4S, the publication is Fenxi Kexue Xuebao (2015), 31(6), 792-796, database is CAplus.

2-Borono-benzaldehyde-(2′-hydroxyl-4′-sulfonate) naphthalene hydrazone derivative 2-BBHSNH (the host 1) was designed and synthesized. Due to its good water solubility, the recognition system didn’t need any organic medium. Research results showed that 2-borono-benzaldehyde-(2′-hydroxyl-4′-sulfonate) naphthalene hydrazone possessed highly selective binding and recognition to Pb²⁺in KH₂PO₄-NaOH buffer solution (pH=6.0). The host 1 and Pb²⁺could form a 1:1 complex with strong fluorescence. The maximum emission wavelength of complex 1-Pb²⁺ was 568 nm and the binding constant was 4.3×10⁴ L·mol^-1. The presence of the other metal ions led fluorescence spectra of host 1 little change, such as Cu²⁺, Mn²⁺, Mg²⁺, Fe²⁺, Ca²⁺, Co²⁺, Ni²⁺, Hg²⁺, Cd²⁺, Ag⁺ and so on. Fluorescence intensity and the concentration of Pb²⁺ presented good linear relationship from 5.0×10^-7-1.0×10^-4 mol·L^-1 with a correlation coefficient of 0.9983, and the detection limit of method was 9.7×10^-8 mol·L^-1. The method was used to detect Pb²⁺in water sample from environment with the recovery of 111%-116%.

Fenxi Kexue Xuebao published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C4H12ClNO, Formula: C10H9NO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Dahal, Gopal P. published the artcileA Fragment Library Screening Approach to Identify Selective Inhibitors against an Essential Fungal Enzyme, Product Details of C10H9NO4S, the publication is SLAS Discovery (2018), 23(6), 520-531, database is CAplus and MEDLINE.

Pathogenic fungi represent a growing threat to human health, with an increase in the frequency of drug-resistant fungal infections. Identifying targets from among the selected metabolic pathways that are unique to microbial species presents an opportunity to develop new antifungal agents against new and untested targets to combat this growth threat. Aspartate semialdehyde dehydrogenase (ASADH) catalyzes a key step in a uniquely microbial amino acid biosynthetic pathway and is essential for microbial viability. This enzyme, purified from four pathogenic fungal organisms (Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans, and Blastomyces dermatitidis), has been screened against fragment libraries to identify initial enzyme inhibitors. The binding of structural analogs of the most promising lead compounds was measured against these fungal ASADHs to establish important structure-activity relationships among these different inhibitor classes. The most potent of these inhibitors have been docked into structures of this fungal enzyme target to identify important structural elements that serve as critical binding determinants. Several inhibitors with low micromolar inhibition constants have been identified that showed selectivity against these related enzymes from different fungal species. Subsequent screening against a library of drugs and drug candidates identified some addnl. inhibitors containing a consistent set of functional groups required for fungal ASADH inhibition. Addnl. elaboration of these core structures will likely lead to more potent and selective inhibitors.

SLAS Discovery published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Product Details of C10H9NO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Patel, Darshna K. published the artcileEnzyme mediated bacterial biotransformation and reduction in toxicity of 1:2 chromium complex AB193 and AB194 dyes, Computed Properties of 116-63-2, the publication is Journal of the Taiwan Institute of Chemical Engineers (2017), 1-9, database is CAplus.

A bacterial consortium was developed and applied for the treatment of 1:2 chromium complex azo dyes. Fed batch process was studied with optimized conditions for the decolorization of AB193 and AB194 up to 1100-1400 mg L^-1 of cumulative dye concentration without further nutrient addition Fed batch adapted consortium showed 39 and 42% enhanced decolorization for AB193 and AB194, resp. as compared to unadapted consortium. After bio-degradation of the dyes, chromium was not detected in the medium supernatant where as chromium was found sorbed on bacterial cell biomass. During the decolorization process laccase, lignin peroxidase, tyrosinase, azoreductase and NADH-DCIP reductase enzymes were found to be induced. HPLC and FTIR anal. data confirmed the biodegradation of both the dyes. Biodegradation pathways were proposed on the basis of H¹ NMR and GC-HRMS anal. along with role of induced enzymic system in the degradation process. 45-66% stimulation in growth was observed for Sorghum bicolor and Cicer aeriatinum when biodegradation products of both the dyes were used. Reduction in toxicity on S. aureus and P. aeruginosa was recorded in the range of 58-100% and 43-100%, resp.

Journal of the Taiwan Institute of Chemical Engineers published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Computed Properties of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Masoud, Mamdouh S. published the artcileSolvatochromic responses and pH effects on the electronic spectra of some azo derivatives of 1-amino-2-hydroxy-4-naphthalenesulfonic acid, Formula: C10H9NO4S, the publication is Journal of the Iranian Chemical Society (2016), 13(5), 931-943, database is CAplus.

Synthesis and characterization of five arylazo derivatives of 1-amino-2-hydroxy-4-naphthalenesulfonic acid (H2L1) are reported. The UV/Vis absorption spectra of the parent compound (H2L1) and its arylazo derivatives (H2L2-H4L6) have been measured at room temperature in seven solvents of different polarities and with variable parameters. The electronic transitions were analyzed using SPSS program, linear regression technique and Kamlet-Taft’s equation to permit a good understanding of solvent-induced spectral shifts. The electronic absorption spectra of the prepared compounds containing different substituents were studied in aqueous solutions at different pH values. The pK values of the investigated compounds were evaluated spectrophotometrically. The prevailing acid species present at any pH range are judged from the constructed distribution diagrams.

Journal of the Iranian Chemical Society published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Formula: C10H9NO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Raza, Rabia published the artcileIdentification of small molecule sulfonic acids as ecto-5′-nucleotidase inhibitors, Product Details of C10H9NO4S, the publication is Medicinal Chemistry (2012), 8(6), 1133-1139, database is CAplus and MEDLINE.

Ecto-5′-Nucleotidase inhibitors have great potential as anti-tumor agents. We have investigated biochem. properties of human and rat ecto-5′-Nucleotidases and characterized 19 small mol. sulfonic acid derivatives as potential inhibitors of ecto-5′-Nucleotidases. We identified 11 potent inhibitors of human and rat ecto-5′-Nucleotidases and checked their selectivity. Compound 10 (Sodium 2,4-dinitrobenzenesulfonate) with K_i value of 0.66 μM and 19 (N-(4-sulfamoylphenylcarbamothioyl) pivalamide) with K_i value of 0.78 μM were identified as the most potent inhibitors for human and rat ecto-5′-Nucleotidase, resp. The present compounds have low mol. weights, water solubility and equal potency as compared to the reported inhibitors.

Medicinal Chemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Product Details of C10H9NO4S.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Vidya, V. G. published the artcileSynthesis, characterization and applications of some azo dyes derived from various aromatic amines, Quality Control of 116-63-2, the publication is Asian Journal of Chemistry (2018), 30(9), 2049-2053, database is CAplus.

In this work, we report the synthesis of metal free dyes and their fastness properties. A series of monoazo dyes were obtained by diazotization of various aromatic primary amines and coupling with different components. One colored Schiff base derived from triethylenetetramine and N,N-dimethyl-4-aminobenzaldehyde was also synthesized. These colored compounds were characterized by FTIR, UV-visible, ¹H, ¹³C NMR and ESI mass spectroscopic methods. The dyeing performance of all the compounds were evaluated on cotton fabric. They were applied on bleached cotton fabric and their dyeing and fastness properties were assessed. The absorption spectra of the dyes are discussed with regard to their structure. The structure of colored dyes and Schiff base are proposed based on various spectroscopic data. The newly synthesized group of monoazo dyes gives shades ranging from yellow to reddish orange with good light fastness and excellent wash fastness.

Asian Journal of Chemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C5H12O2, Quality Control of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Wang, Huiwen published the artcileMonitoring of Parathion-Methyl Based on PtNPs Combined with 4-Amino-3-Hydroxy-1-Naphthalenesulfonic Acid Fluorescent Probe and Enzyme Inhibition, SDS of cas: 116-63-2, the publication is Chemistry Africa (2022), 5(1), 99-105, database is CAplus.

In this paper, a new fluorescence anal. method was proposed to detect parathion-Me (PM) based on platinum nanoparticles (PtNPs) and 4-amino-3-hydroxy-1-naphthalenesulfonic acid (AHNSA) as fluorescent probe. AHNSA with high fluorescence could combine with PtNPs by electrostatic attraction, bringing out fluorescence quenching of AHNSA. Acetylthiocholine (ATCh) was hydrolyzed by acetylcholinesterase (AChE) to produce thiocholine, which could induce the aggregation of PtNPs by electrostatic attraction and restore the fluorescence intensity of AHNSA. However, in the presence of PM, the catalytic activity of AChE is inhibited, leading to the quenching of fluorescence of AHNSA again. Under the optimal conditions, the linear range of parathion-Me (PM) detection was 0.26-53.3 ng/mL (R2 = 0.994), and the limit of detection was 0.17 ng/mL (S/N = 3). In addition, this method has been successfully used for the determination of PM in water and food samples.

Chemistry Africa published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C7H13NO2, SDS of cas: 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Parte, Satish published the artcileBiodegradation of sulfonated aromatic amine by Pseudomonas desmolyticum NCIM 2112, Related Products of naphthyridine, the publication is Journal of Chemical and Pharmaceutical Research (2013), 5(4), 335-339, database is CAplus.

Environmental pollutions caused by the release of wide range of compounds from various industries such as paper pulp and textiles have a serious effect on ecosystem and human health. Sulfonated azo dyes represent a large class of dyes used in textile industries. The precursors of these dyes are sulfonated aromatic amines. Release of such toxic compounds in the environment cause toxic effects on soil fertility and aquatic ecosystem. Limited attention has been paid towards the fate of sulfonated aromatic amines and substituted sulfonated aromatic amines in the environment previously. The present research work describes biodegradation of azo dye precursor 1-amino 2-naphthol 4-sulfonic acid by Pseudomonas desmolyticum NCIM 2112 which was studied by FTIR and GCMS anal. The resulting metabolites of biodegradation include propylmethane thiosulfonate and aminobenzene and they were found to be nontoxic in the environment.

Journal of Chemical and Pharmaceutical Research published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Related Products of naphthyridine.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Dutta Gupta, Sayan published the artcile2,4-dihydroxy benzaldehyde derived Schiff bases as small molecule Hsp90 inhibitors: Rational identification of a new anticancer lead, Computed Properties of 116-63-2, the publication is Bioorganic Chemistry (2015), 97-105, database is CAplus and MEDLINE.

Hsp90 is a mol. chaperone that heals diverse array of biomols. ranging from multiple oncogenic proteins to the ones responsible for development of resistance to chemotherapeutic agents. Moreover they are over-expressed in cancer cells as a complex with co-chaperones and under-expressed in normal cells as a single free entity. Hence inhibitors of Hsp90 will be more effective and selective in destroying cancer cells with min. chances of acquiring resistance to them. In continuation of our goal to rationally develop effective small mol. azomethines against Hsp90, we designed few more compounds belonging to the class of 2,4-dihydroxy benzaldehyde derived imines (1-13) with our validated docking protocol. The mols. exhibiting good docking score were synthesized and their structures were confirmed by IR, ¹H NMR and mass spectral anal. Subsequently, they were evaluated for their potential to suppress Hsp90 ATPase activity by Malachite green assay. The antiproliferative effect of the mols. were examined on PC3 prostate cancer cell lines by adopting 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay methodol. Finally, schiff base 13 emerged as the lead mol. for future design and development of Hsp90 inhibitors as anticancer agents.

Bioorganic Chemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Computed Properties of 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem

Sivakumar, Kullampalayam Krishnasamy published the artcileConventional and microwave assisted synthesis of pyrazolone Mannich bases possessing anti-inflammatory, analgesic, ulcerogenic effect and antimicrobial properties, SDS of cas: 116-63-2, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(13), 2940-2944, database is CAplus and MEDLINE.

In the present study, an efficient synthesis of some Mannich base of 5-methyl-2-[(2-oxo-2H-chromen-3-yl)carbonyl]-2,4-dihydro-3H-pyrazol-3-one was carried out by using conventional and non-conventional (microwave) techniques. Microwave assisted reactions showed that require shorter reaction time and good yield. The newly synthesized compounds were screened for their anti-inflammatory, analgesic activity, antioxidant, and antibacterial effects were compared with standard drug. Among the compounds studied, one compound showing nearly equipotent anti-inflammatory and analgesic activity than the standard drug (indomethacin), along with min. ulcerogenic index. Two compounds showing 1.06 times more active than ciprofloxacin against tested Gram-neg. bacteria.

Bioorganic & Medicinal Chemistry Letters published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C9H5ClO4S, SDS of cas: 116-63-2.

Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem