Kallen, Joerg et al. published their research in ChemMedChem in 2018 | CAS: 1009820-21-6

5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid (cas: 1009820-21-6) belongs to naphthyridine derivatives. Functionalized naphthyridines and their benzo/heterofused analogs are present in numerous marine products and reported to possess wide-ranging activities such as antiproliferative, antiaggressive, and HIV-1 integrase inhibition in addition to their use as anti-HCV agents. 1,6-Naphthyridine and some of its derivatives have been reported to have medicinal, electronic, and catalytic properties. But none of these investigations has yet resulted in any practical applications.Synthetic Route of C19H12ClN3O2

X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan-McDermid Syndrome was written by Kallen, Joerg;Bergsdorf, Christian;Arnaud, Bertrand;Bernhard, Mario;Brichet, Murielle;Cobos-Correa, Amanda;Elhajouji, Azeddine;Freuler, Felix;Galimberti, Ivan;Guibourdenche, Christel;Haenni, Simon;Holzinger, Sandra;Hunziker, Juerg;Izaac, Aude;Kaufmann, Markus;Leder, Lukas;Martus, Hans-Joerg;von Matt, Peter;Polyakov, Valery;Roethlisberger, Patrik;Roma, Guglielmo;Stiefl, Nikolaus;Uteng, Marianne;Lerchner, Andreas. And the article was included in ChemMedChem in 2018.Synthetic Route of C19H12ClN3O2 This article mentions the following:

CLK2 inhibition has been proposed as a potential mechanism to improve autism and neuronal functions in Phelan-McDermid syndrome (PMDS). Herein, the discovery of a very potent indazole CLK inhibitor series and the CLK2 x-ray structure of the most potent analog are reported. This new indazole series was identified through a biochem. CLK2 Caliper assay screen with 30k compounds selected by an in silico approach. Novel high-resolution x-ray structures of all CLKs, including the first CLK4 x-ray structure, bound to known CLK2 inhibitor tool compounds (e.g., TG003, CX-4945), are also shown and yield insight into inhibitor selectivity in the CLK family. The efficacy of the new CLK2 inhibitors from the indazole series was demonstrated in the mouse brain slice assay, and potential safety concerns were investigated. Genotoxicity findings in the human lymphocyte micronucleus test (MNT) assay are shown by using two structurally different CLK inhibitors to reveal a major concern for pan-CLK inhibition in PMDS. In the experiment, the researchers used many compounds, for example, 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid (cas: 1009820-21-6Synthetic Route of C19H12ClN3O2).

5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid (cas: 1009820-21-6) belongs to naphthyridine derivatives. Functionalized naphthyridines and their benzo/heterofused analogs are present in numerous marine products and reported to possess wide-ranging activities such as antiproliferative, antiaggressive, and HIV-1 integrase inhibition in addition to their use as anti-HCV agents. 1,6-Naphthyridine and some of its derivatives have been reported to have medicinal, electronic, and catalytic properties. But none of these investigations has yet resulted in any practical applications.Synthetic Route of C19H12ClN3O2

Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem