ALSUntangled 57: Vinpocetine was written by Bedlack, Richard;Armon, Carmel;Barkhaus, Paul;Barnes, Benjamin;Bereman, Michael;Bertorini, Tulio;Carter, Greg;Chen, Amy;Crayle, Jesse;Cudkowicz, Merit;Jackson, Carlayne;Kiernan, Matthew;Levitsky, Gleb;McDermott, Christopher;Pattee, Gary;Pioro, Erik;Salmon, Kristiana;Staats, Kim;Stephens, James;Wicks, Paul. And the article was included in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration in 2021.Recommanded Product: (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate This article mentions the following:
Vinpocetine (chem. name 14-ethoxycarbonyl- (3a,16a-ethyl)-14,15-eburnamine) is a product derived from an alkaloid substance in the periwinkle plant Vinca minor (2). In many countries it is classified as a prescription drug and is used for the treatment of acute stroke and cognitive impairment(3). Systematic reviews have failed to confirm any benefits for patients with these conditions (4,5). In the Unites States, it is classified as a nutritional supplement (3). At least one website claims that Vinpocetine might be “beneficial for ALS” (6). A published case series demonstrated that Vinpocetine was associated with reduced cramping in PALS and suggested further study, including determining whether it could slow ALS progression (7). This review examines Vinpocetine′s potential role in slowing ALS progression. In the experiment, the researchers used many compounds, for example, (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5Recommanded Product: (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate).
(41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (cas: 42971-09-5) belongs to naphthyridine derivatives. The naphthyridines have 10 delocalized π-electrons located in five molecular orbitals, each of which is distorted by the presence of the nitrogen atoms causing an electron drift in that direction. Very few metal complexes of naphthyridines other than 1,8-naphthyridine have been described.Recommanded Product: (41S,13aS)-Ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem