Aikawa, Kohsuke published the artcilePalladium-Catalyzed Negishi Cross-Coupling Reaction of Aryl Halides with (Difluoromethyl)zinc Reagent, Recommanded Product: 1-(Difluoromethyl)naphthalene, the publication is Organic Letters (2016), 18(15), 3690-3693, database is CAplus and MEDLINE.
The palladium-catalyzed Negishi cross-coupling reaction of aryl iodides I [R = CN-4, NO2-4, CO2Et-4, Cl-4, (Bu-t)-4, OMe-4, Ph-4, Me2-3,5, CHOCHCHOCH-2,3, Me3-2,4,6; X = I] and bromides I [R = NO2-4, CO2Et-4, (Bu-t)-4, CN-3; X = Br] with (difluoromethyl)zinc reagent bearing a diamine such as TMEDA is achieved to provide the difluoromethylated aromatic compounds II in good to excellent yields. The advantages of (difluoromethyl)zinc reagent are that (1) the derivatives, which possess different stability and reactivity, can be readily prepared via ligand screening and (2) transmetalation of a difluoromethyl group from the zinc reagent to palladium catalyst efficiently proceeds without an activator.
Organic Letters published new progress about 53731-26-3. 53731-26-3 belongs to naphthyridine, auxiliary class Difluoromethyl,Fluoride,Naphthalene, name is 1-(Difluoromethyl)naphthalene, and the molecular formula is C11H8F2, Recommanded Product: 1-(Difluoromethyl)naphthalene.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem