Dutta Gupta, Sayan published the artcile2,4-dihydroxy benzaldehyde derived Schiff bases as small molecule Hsp90 inhibitors: Rational identification of a new anticancer lead, Computed Properties of 116-63-2, the publication is Bioorganic Chemistry (2015), 97-105, database is CAplus and MEDLINE.
Hsp90 is a mol. chaperone that heals diverse array of biomols. ranging from multiple oncogenic proteins to the ones responsible for development of resistance to chemotherapeutic agents. Moreover they are over-expressed in cancer cells as a complex with co-chaperones and under-expressed in normal cells as a single free entity. Hence inhibitors of Hsp90 will be more effective and selective in destroying cancer cells with min. chances of acquiring resistance to them. In continuation of our goal to rationally develop effective small mol. azomethines against Hsp90, we designed few more compounds belonging to the class of 2,4-dihydroxy benzaldehyde derived imines (1-13) with our validated docking protocol. The mols. exhibiting good docking score were synthesized and their structures were confirmed by IR, 1H NMR and mass spectral anal. Subsequently, they were evaluated for their potential to suppress Hsp90 ATPase activity by Malachite green assay. The antiproliferative effect of the mols. were examined on PC3 prostate cancer cell lines by adopting 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay methodol. Finally, schiff base 13 emerged as the lead mol. for future design and development of Hsp90 inhibitors as anticancer agents.
Bioorganic Chemistry published new progress about 116-63-2. 116-63-2 belongs to naphthyridine, auxiliary class Sulfonic acid,Amine,Naphthalene,Alcohol,Organic Pigment, name is 4-Amino-3-hydroxynaphthalene-1-sulfonic acid, and the molecular formula is C10H9NO4S, Computed Properties of 116-63-2.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem