Romeiro, Nelilma C. published the artcileSynthesis, pharmacological evaluation and docking studies of new sulindac analogues, Product Details of C20H17FO4S, the publication is European Journal of Medicinal Chemistry (2009), 44(5), 1959-1971, database is CAplus and MEDLINE.
This paper describes the synthesis, pharmacol. evaluation and docking studies of a series of new sulindac analogs. Overall, the designed compounds revealed good, in vivo, antinociceptive activity and satisfactory anti-inflammatory profile. Flexible mol. docking with COX-1/COX-2 has shown putative binding modes of the designed compounds while the theor. evaluation of cell permeability based on Lipinski’s rule of five has helped rationalize the biol. results.
European Journal of Medicinal Chemistry published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Product Details of C20H17FO4S.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem