Kaminskaia, Natalia V. published the artcileReactivity of μ-Hydroxodizinc(II) Centers in Enzymatic Catalysis through Model Studies, Recommanded Product: 2,7-Dimethyl-1,8-naphthyridine, the publication is Inorganic Chemistry (2000), 39(15), 3365-3373, database is CAplus and MEDLINE.
The stable dinuclear complex [Zn2(BPAN)(μ-OH)(μ-O2PPh2)](ClO4)2, where BPAN = 2,7-bis[2-(2-pyridylethyl)aminomethyl]-1,8-naphthyridine, was chosen as a model to investigate the reactivity of (μ-hydroxo)dizinc(II) centers in metallohydrolases. Two reactions, the hydrolysis of phosphodiesters and the hydrolysis of β-lactams, were studied. These two processes are catalyzed in vivo by the zinc(II)-containing enzymes P1 nuclease and β-lactamase, resp. P1 nucleases catalyze the hydrolysis of single-stranded DNA and RNA, while β-lactamases are expressed in many types of pathogenic bacteria and are responsible for the hydrolytic degradation of β-lactam antibiotic drugs. In the first step of phosphodiester hydrolysis promoted by the dinuclear model complex, the substrate replaces the bridging diphenylphosphinate. The bridging hydroxide serves as a general base to deprotonate water, which acts as a nucleophile in the ensuing hydrolysis. The dinuclear model complex is only 1.8 times more reactive in phosphodiester hydrolysis than a mononuclear analog, Zn(bpta)(OTf)2, where bpta = N,N-bis(2-pyridylmethyl)-tert-butylamine. Hydrolysis of nitrocefin, a β-lactam antibiotic analog, catalyzed by [Zn2(BPAN)(μ-OH)(μ-O2PPh2)](ClO4)2 involves monodentate coordination of the substrate via its carboxylate group, followed by nucleophilic attack of the zinc(II)-bound terminal hydroxide at the β-lactam carbonyl carbon atom. Collapse of the tetrahedral intermediate results in product formation. Mononuclear complexes Zn(cyclen)(NO3)2 and Zn(bpta)(NO3)2, where cyclen = 1,4,7,10-tetraazacyclododecane, are as reactive in the β-lactam hydrolysis as the dinuclear complex. Kinetic and mechanistic studies of the phosphodiester and β-lactam hydrolyzes indicate that the bridging hydroxide in [Zn2(BPAN)(μ-OH)(μ-O2PPh2)](ClO4)2 is not very reactive, despite its low pKa value. This low reactivity presumably arises from the two factors. First, the bridging hydroxide and coordinated substrate in [Zn2(BPAN)(μ-OH)(substrate)]2+ are not aligned properly to favor nucleophilic attack. Second, the nucleophilicity of the bridging hydroxide is diminished because it is simultaneously bound to the two zinc(II) ions.
Inorganic Chemistry published new progress about 14903-78-7. 14903-78-7 belongs to naphthyridine, auxiliary class 6.6_Aromatics,Naphthyridines, name is 2,7-Dimethyl-1,8-naphthyridine, and the molecular formula is C10H10N2, Recommanded Product: 2,7-Dimethyl-1,8-naphthyridine.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem