Jia, Zhongjiang published the artcileDetermination of drug-polymer binding constants by affinity capillary electrophoresis for aryl propionic acid derivatives and related compounds, Name: Sulindac sulfone, the publication is Journal of Pharmaceutical Sciences (2013), 102(3), 960-966, database is CAplus and MEDLINE.
The binding constants (Kbs) of 17 aryl propionic acid derivatives (APADs) and related compounds with polyvinylpyrrolidone (PVP K30) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA64) in aqueous media were determined by affinity capillary electrophoreses (ACE). The Kbs of APAD to polymers increase with octanol-water partition coefficients of the compounds Kollidon VA64 is a stronger binder than PVP K30 to APAD compounds The Kbs are greater at pH 4 than at pH 9. Both hydrophobic interaction and hydrogen bonding may be involved. However, hydrophobic interaction appears to be dominant. The ACE method is simple and fast, which could be used to study drug-polymer interaction in aqueous media. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci.
Journal of Pharmaceutical Sciences published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Name: Sulindac sulfone.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem