Bouchard, Geraldine published the artcileLipophilicity and solvation of anionic drugs, COA of Formula: C20H17FO4S, the publication is Chemistry – A European Journal (2002), 8(15), 3478-3484, database is CAplus and MEDLINE.
This paper first gives a brief review of the main techniques used to measure the lipophilicity of neutral and ionic drugs, namely the shake-flask method, potentiometry, and cyclic voltammetry at liquid-liquid interfaces. The lipophilicity of 28 acidic compounds with various functional groups was studied by potentiometry and cyclic voltammetry in the n-octanol/water and 1,2-dichloroethane/water systems in order to complement our understanding of the lipophilicity of neutral and ionized acids and to clarify the solvation mechanisms responsible for their partition. The parameter diff(log PdceN-A) (i.e., log P of the neutral acid minus standard log P of the conjugated anion in 1,2-dichloroethane/water) was shown to depend not only on intramol. interactions and conformational effects in the neutral and anionic forms, but also on the delocalization of the neg. charge in the anion, confirming the ability of Born’s solvation model to describe qual. the effect of the mol. radius on the lipophilicity of ions.
Chemistry – A European Journal published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, COA of Formula: C20H17FO4S.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem