Krier, Fabrice published the artcileOptimisation and validation of a fast HPLC method for the quantification of sulindac and its related impurities, Category: naphthyridine, the publication is Journal of Pharmaceutical and Biomedical Analysis (2011), 54(4), 694-700, database is CAplus and MEDLINE.
The European Pharmacopoeia describes a liquid chromatog. (LC) method for the quantification of sulindac, using a quaternary mobile phase including chloroform and with a rather long run time. In the present study, a new method using a short sub-2 μm column, which can be used on a classical HPLC system, was developed. The new LC conditions (without chloroform) were optimized by means of a new methodol. based on design of experiments in order to obtain an optimal separation Four factors were studied: the duration of the initial isocratic step, the percentage of organic modifier at the beginning of the gradient, the percentage of organic modifier at the end of the gradient and the gradient time. The optimal condition allows the separation of sulindac and of its 3 related impurities in 6 min instead of 18 min. Finally, the method was successfully validated using an accuracy profile approach in order to demonstrate its ability to accurately quantify these compounds
Journal of Pharmaceutical and Biomedical Analysis published new progress about 59973-80-7. 59973-80-7 belongs to naphthyridine, auxiliary class Immunology/Inflammation,COX, name is Sulindac sulfone, and the molecular formula is C20H17FO4S, Category: naphthyridine.
Referemce:
https://en.wikipedia.org/wiki/1,8-Naphthyridine,
1,8-Naphthyridine | C8H6N2 – PubChem