Hou, Zhifei; Sun, Guoxiang; Guo, Yong; Yang, Fangliang; Gong, Dandan published the artcile< Capillary electrophoresis fingerprints combined with Linear Quantitative Profiling Method to monitor the quality consistency and predict the antioxidant activity of Alkaloids of Sophora flavescens>, Safety of (41S,7aR,13aR,13bR)-Dodecahydro-1H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10(41H)-one, the main research area is Sophora antioxidant alkaloid determination capillary electrophoresis; Alkaloids of Sophora flavescens; Capillary electrophoresis fingerprints; Fingerprint-efficacy relationship; Quality consistency; The total antioxidant capacity.
Alkaloids of Sophora flavescens (ASF) has various pharmacol. effects, and it is widely used in clin. practice. The aim of this research was to develop an environmentally friendly methodol. that enables not only identification but also the quality consistency assessment of Alkaloids of Sophora flavescens. A background electrolyte composed of 50 mmol/L sodium tetraborate solution, 500 mmol/L boric acid and 1.2 mmol/L citric acid was used to conduct the fingerprint anal. coupled with quant. determination of three components. Linear quant. profiling method was used for comprehensive quality discrimination of the test samples from both qual. and quant. perspectives, and the 27 batches of samples were well differentiated. In addition, the fingerprint-efficacy relationship between chem. components and antioxidant activity in vitro was established using partial least squares regression model, which provided important medicinal efficacy information for quality control.
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about Alkaloids Role: ANT (Analyte), THU (Therapeutic Use), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 6882-68-4 belongs to class naphthyridine, and the molecular formula is C15H24N2O, Safety of (41S,7aR,13aR,13bR)-Dodecahydro-1H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10(41H)-one.
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem