Tang, Qing; Luo, Ding; Lin, Ding-Chai; Wang, Wen-Zhi; Li, Can-Jie; Zhuo, Xue-Fang; Wu, Zhong-Nan; Zhang, Yu-Bo; Wang, Guo-Cai; Li, Yao-Lan published the artcile< Five matrine-type alkaloids from Sophora tonkinensis>, HPLC of Formula: 6882-68-4, the main research area is Sophora root 1213 dehydrosophoridine isosophocarpine sophoridine; 12,13-dehydrosophoridine; 13β-hydroxymatrine; Anti-inflammatory activity; Matrine-type alkaloid; Sophora tonkinensis.
Five matrine-type alkaloids (1-5) including two new compounds (1 and 3) and a new natural product (2) were isolated from the roots of Sophora tonkinesis. Their structures were identified by extensive spectroscopic anal. (UV, IR, HRESIMS and NMR). The absolute configurations of 2 and 3 were determined by X-ray diffraction. Compounds 1-5 were evaluated their activity against inflammatory cytokines TNF-α and IL-6 levels on LPS-induced RAW 264.7 macrophages, and compound 1 showed the most significant activity, potent than that of matrine, the representative ingredient from Sophora plants. Graphic abstract: [graphic not available: see fulltext]
Journal of Natural Medicines published new progress about Alkaloids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 6882-68-4 belongs to class naphthyridine, and the molecular formula is C15H24N2O, HPLC of Formula: 6882-68-4.
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem