The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Iodo-2-furaldehyde, is researched, Molecular C5H3IO2, CAS is 2689-65-8, about [4+2] Cycloaddition of α,β-unsaturated acid anhydrides to 2-furylpiperidin-4-ones: The short route to annulated 8,10a-epoxypyrido[2,1-a]isoindoles, the main research direction is regioselective stereoselective preparation epoxypyridoisoindole; intramol Diels Alder reaction furfurylacrylamide unsaturated anhydride.Quality Control of 5-Iodo-2-furaldehyde.
A one-step preparation procedure of 8,10a-epoxypyrido[2,1-a]isoindoles and their 7-carboxylic derivatives is reported. The key synthetic step includes the intramol. exo-Diels-Alder reaction (IMDAF) of N-furfurylacrylamide, produced in situ from 2-furylpiperidin-4-ones and α,β-unsaturated acid anhydrides. The synthesis of the title compounds can be performed under mild conditions with a high level of regio- and stereoselectivity. The same strategy has been successfully used for the synthesis of 9,11a-epoxyimidazo[4′,5′:3,4]pyrido[2,1-a]isoindole-8-carboxylic acid from maleic anhydride and the spinacine derivatives – 4-(2-furyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridines.
Although many compounds look similar to this compound(2689-65-8)Quality Control of 5-Iodo-2-furaldehyde, numerous studies have shown that this compound(SMILES:IC1=CC=C(O1)C=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem