In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Ligand-Promoted Meta-C-H Arylation of Anilines, Phenols, and Heterocycles, published in 2016-07-27, which mentions a compound: 2689-65-8, mainly applied to regioselective meta arylation aniline phenol heterocycle aryl iodide; hydroxypyridine ligand meta arylation aniline phenol heterocycle aryl iodide; lenalidomide meta arylation, Formula: C5H3IO2.
The authors report the development of a versatile 3-acetylamino-2-hydroxypyridine class of ligands that promote meta-C-H arylation of anilines, heterocyclic aromatic amines, phenols, and 2-benzyl heterocycles using norbornene as a transient mediator. More than 120 examples are presented, demonstrating this ligand scaffold enables a wide substrate and coupling partner scope. Meta-C-H arylation with heterocyclic aryl iodides as coupling partners is also realized for the first time using this ligand. The utility for this transformation for drug discovery is showcased by allowing the meta-C-H arylation of a lenalidomide derivative The first steps toward a silver-free protocol for this reaction are also demonstrated.
Although many compounds look similar to this compound(2689-65-8)Formula: C5H3IO2, numerous studies have shown that this compound(SMILES:IC1=CC=C(O1)C=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem