Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, RSC Advances called Synthesis of novel (benzimidazolyl)isoquinolinols and evaluation as adenosine A1 receptor tools, Author is Singh, Sameek; Cooper, Samantha L.; Glenn, Jacqueline R.; Beresford, Jessica; Percival, Lydia R.; Tyndall, Joel D. A.; Hill, Stephen J.; Kilpatrick, Laura E.; Vernall, Andrea J., which mentions a compound: 91523-50-1, SMILESS is OC(=O)C1NCCC2=C1C=CC(O)=C2, Molecular C10H11NO3, Recommanded Product: 91523-50-1.
G protein-coupled receptors (GPCRs) constitute the largest family of transmembrane receptors in eukaryotes. The adenosine A1 receptor (A1AR) is a class A GPCR that is of interest as a therapeutic target particularly in the treatment of cardiovascular disease and neuropathic pain. Increased knowledge of the role A1AR plays in mediating these pathophysiol. processes will help realize the therapeutic potential of this receptor. There is a lack of enabling tools such as selective fluorescent probes to study A1AR, therefore we designed a series of (benzimidazolyl)isoquinolinols conjugated to a fluorescent dye (31-35, 42-43). An improved procedure for the synthesis of isoquinolinols from tetrahydroisoquinolinols via oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and atm. oxygen is reported. This synthetic method offers advantages over previous metal-based methods for the preparation of isoquinolinols and isoquinolines, which are important scaffolds found in many biol. active compounds and natural products. We report the first synthesis of the (benzimidazolyl)isoquinolinol compound class, however the fluorescent conjugates were not successful as A1AR fluorescent ligands.
In some applications, this compound(91523-50-1)Recommanded Product: 91523-50-1 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem