The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-Methyl-1,8-naphthyridine( cas:1569-17-1 ) is researched.SDS of cas: 1569-17-1.Jones, Richard A. Y.; Wagstaff, Nigel published the article 《Kinetics of quaternization of some naphthyridines and methylnaphthyridines》 about this compound( cas:1569-17-1 ) in Chemical Communications (London). Keywords: quaternization kinetics heterocycle; kinetics quaternization heterocycle; heterocycle quaternization kinetics; naphthyridines quaternization kinetics; quinoline quaternization kinetics; isoquinoline quaternization kinetics. Let’s learn more about this compound (cas:1569-17-1).
The 2nd order rate constants for the reaction of MeI with some naphthyridines and methylnaphthridines in MeCN were determined by a conductimetric method. The following results were obtained at 24.8° (compound, and rate constant × 10-4 l./mole/sec. given): quinoline, 0.517; isoquinoline, 4.23; 1,5-naphthyridine, 0.232; 1,6-naphthyridine, 1.66; 1,8-naphthyridine, 4.25; 2-methyl-1,8-naphthyridine, 3.61; 3-methyl-1,8-naphthyridine, 5.74; 4-methyl-1,8-naphthyridine, 7.26; and 2,7-dimethyl-1,8-naphthyridine, 1.85. The rate constants are used to deduce the quaternization kinetics of the reactions.
There is still a lot of research devoted to this compound(SMILES：CC1=C2C=CC=NC2=NC=C1)SDS of cas: 1569-17-1, and with the development of science, more effects of this compound(1569-17-1) can be discovered.
Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem