New learning discoveries about 100361-18-0

With the rapid development of chemical substances, we look forward to future research findings about 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid, cas is 100361-18-0, it is a common heterocyclic compound, the naphthyridine compound, its synthesis route is as follows.

To a solutionof 3-amino-3-pyrrolidin-3-yl-propionitrile (200 mg, 1.44 mmol) and7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1, 4-dihydro-[l,8] naphthyridine-3-carboxylic acid(282 mg, 1.00 mmol) in acetonitrile (10mL) was added triethylamine (505 mg, 5.00 mmol) and the solution was heated at 80 C for 17 hours. The precipitate was collected by vacuum filtration and rinsed with acetonitrile. The solid was dried overnight at 45 C under vacuum to give 240 mg of the title compound (yield: 62%). MS (APCI+):mAz 386 (M+H)., 100361-18-0

With the rapid development of chemical substances, we look forward to future research findings about 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid

Reference£º
Patent; WARNER-LAMBERT COMPANY LLC; WO2005/49602; (2005); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem