New learning discoveries about 254-79-5

With the rapid development of chemical substances, we look forward to future research findings about 1,5-Naphthyridine

1,5-Naphthyridine, cas is 254-79-5, it is a common heterocyclic compound, the naphthyridine compound, its synthesis route is as follows.

Example 12; 220 221 222Part A: To a solution of compound 220 (1.0Og, 6.02 mmol) in carbon tetrachloride (60 ml_) was added dropwise, bromine (1.15 g, 7.20 mmol) as a carbon tetrachloride solution (6 mL). The resulting solution was refluxed for 1 hour. Pyridine (0.5 ml_, 6.0 mmol) as a carbon tetrachloride solution (10 mL) was added over a period of 1 hour to the refluxing reaction mixture. The reaction was stirred at reflux for 16 hours at which time LC-MS indicated that the reaction was complete. The reaction mixture was cooled to room temperature, resulting in the formation of a precipitate, which was filtered. The carbon tetrachloride filtrate was set aside. The collected brown solid was taken up in 10% NaOH (100 mL) and stirred at room temperature for 1 hour. This solution was extratcted with chloroform. The chloroform and carbon tetrachloride solutions were combined and concentrated in vacuum. Purification by column chromatography (Sitheta2, 20% EtOAc / DCM) afforded compound 221 as a white solid 0.17 g, (14%). 1H NMR (400 MHz, DMSO-d6) delta 9.07 (d, 1 H), 9.02 (dd, 1 H), 8.74 (m, 1 H), 8.45 (m, 1 H), 7.83 (dd, 1 H)., 254-79-5

With the rapid development of chemical substances, we look forward to future research findings about 1,5-Naphthyridine

Reference£º
Patent; SCHERING CORPORATION; WO2008/82487; (2008); A2;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem