Analyzing the synthesis route of 17965-71-8

With the synthetic route has been constantly updated, we look forward to future research findings about 3-Bromo-1,5-naphthyridine,belong naphthyridine compound

As a common heterocyclic compound, it belong naphthyridine compound,3-Bromo-1,5-naphthyridine,17965-71-8,Molecular formula: C8H5BrN2,mainly used in chemical industry, its synthesis route is as follows.,17965-71-8

3-bromonaphthyridine (44.5 g, 0.213 mol), absolute ethanol (357 mL),N,N-dimethylformamide (90 mL) was added, palladium chloride (2.65 g), triethylamine (32.28 g, 0.32 mol),The reaction liquid was spin-dried by reacting carbon monoxide at a pressure of 0.8 MPa at 75 C for 6 h.Use petroleum ether: ethyl acetate = 10:1 ~ 1:1 over the column,Methyl 1,5-naphthyridin-3carboxylate (34 g, white solid, yield 84%).

With the synthetic route has been constantly updated, we look forward to future research findings about 3-Bromo-1,5-naphthyridine,belong naphthyridine compound

Reference£º
Patent; Suzhou Kangrun Pharmaceutical Co., Ltd.; Jin Haowen; Xu Weiliang; Xu Weizheng; (8 pag.)CN108658977; (2018); A;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem