Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. 89343-06-6, Name is Ethynyltriisopropylsilane, SMILES is CC([Si](C(C)C)(C#C)C(C)C)C, belongs to naphthyridine compound. In a document, author is Sakram, Boda, introduce the new discover, Product Details of 89343-06-6.
A highly efficient and simple procedure has been developed for the synthesis of 9-(3-fluoro-4-methoxyphenyl)-6-aryl-[1,2,4]triazolo[4,3-a][1,8] naphthyridines by ionic liquid Cu(II) oxidative cyclization of 2-(2-(3-fluoro-4-methoxybenzylidene)hydrazinyl)-3-phenyl-1,8-naphthyridine under microwave irradiation. Synthesized compounds have been described by microanalysis, infrared, H-1 NMR spectroscopy, and mass spectrometry. Sixteen of the synthesized compounds were evaluated for their antimicrobial activity against bacteria, such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumoniae, as well as fungi, such as Aspergillus flavus and Fusarium oxysporum. Results of the antimicrobial screening showed that the compounds 3b, 3g, and 3j have maximal zones of inhibition against the tested bacterial strains. Docking studies were carried out for the three most active compounds 3b, 3g, and 3j along with the inactive compound 3a.
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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem