Chemical engineers work across a number of sectors, processes differ within each of these areas, but chemical engineering roles are found throughout, creation and manufacturing process of chemical products and materials. In an article, author is Defaux, Julien, once mentioned the application of 5089-22-5, Name is 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene. Now introduce a scientific discovery about this category, Application In Synthesis of 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene.
As part of our research projects to identify new chemical entities of biological interest, we developed a synthetic approach and the biological evaluation of (7-aryl-1,5-naphthyridin-4-yl)ureas as a novel class of Aurora kinase inhibitors for the treatment of malignant diseases based on pathological cell proliferation. 1,5-Naphthyridine derivatives showed excellent inhibitory activities toward Aurora kinases A and B, and the most active compound, 1-cyclopropyl-3-[7-(1-methyl-1H-pyrazol-4-yl)-1,5-naphthyridin-4-yl]urea (49), displayed IC50 values of 13 and 107nM against Aurora kinases A and B, respectively. In addition, the selectivity toward a panel of seven cancer-related protein kinases was highlighted. In vitro ADME properties were also determined in order to rationalize the difficulties in correlating antiproliferative activity with Aurora kinase inhibition. Finally, the good safety profile of these compounds imparts promising potential for their further development as anticancer agents.
The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In my other articles, you can also check out more blogs about 5089-22-5. Application In Synthesis of 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem