2-Oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylic acid, cas is 5175-14-4, it is a common heterocyclic compound, the naphthyridine compound, its synthesis route is as follows.
5175-14-4, Step 3: 3-Bromo-l,8-naphthyridin-2-olA solution of bromine (3.78 g, 23.7 mmol) in pyridine (4 mL) and DMF (8 mL) was added to the product of Step 2 (450 mg, 2.37 mmol) and heated at 1050C for 1 hour. The reaction was cooled; H2O was added, and the mixture filtered. The filtrate was extracted with EtOAc (2x). The organic layers washed with brine and saturated NH4Cl(aq.) and dried over Na2SO4. The solvent was concentrated in vacuo, and the resulting gum was triturated with DCM, and filtered to give a brown solid (156 mg) as desired product. M+H = 224.9.
With the rapid development of chemical substances, we look forward to future research findings about 2-Oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylic acid
Reference£º
Patent; MERCK & CO., INC.; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.; WO2008/57209; (2008); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem