Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 132-64-9, Name is Dibenzo[b,d]furan, molecular formula is C12H8O, SDS of cas: 132-64-9, belongs to naphthyridine compound, is a common compound. In a patnet, author is Akula, Mahesh, once mentioned the new application about 132-64-9.
A simple route for preparation of 4-substituted thieno/furo[2,3-c]quinoline compounds is reported in this paper. These compounds were synthesized by using Suzuki coupling between appropriate boronic acid and 2-iodoaniline, followed by reaction with diverse aldehydes in the presence of a catalytic amount of FeCl3. Naphthyridine analogues were also prepared in order to demonstrate the efficacy of the developed method. Further anti-tubercular activity screening of the molecules was undertaken, wherein compounds bearing a fused furo[2,3-c][1,8]naphthyridine skeleton displayed highest activity. The best MIC (minimum inhibitory concentration) value of 5.6 mu mol was obtained for 4-(4-methoxyphenyl)furo[2,3-c][1,8]naphthyridine, which is found to be superior to the existing first line anti-tubercular drug ethambutol (7.6 mu mol).
These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 132-64-9, SDS of cas: 132-64-9.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem