New discoveries in chemical research and development in 2021. 5089-22-5, Name is 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene, molecular formula is C24H14N2O2, Safety of 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene, belongs to naphthyridine compound, is a common compound. In a patnet, author is Kandepedu, Nishanth, once mentioned the new application about 5089-22-5.
A novel 2,8-disubstituted-1,5-naphthyridine hit compound stemming from the open access Medicines for Malaria Venture Pathogen Box formed a basis for a hit-to-lead medicinal chemistry program. Structure-activity relationship investigations resulted in compounds with potent antiplasmodial activity against both chloroquine sensitive (NF54) and multidrug resistant (K1) strains of the human malaria parasite Plasmodium falciparum. In the humanized P. falciparum mouse efficacy model, one of the frontrunner compounds showed in vivo efficacy at an oral dose of 4 X 50 mg.g(-1). In vitro mode-of-action studies revealed Plasmodium falciparum phosphatidylinositol-4-kinase as the target.
In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts intended to model and predict the effects of solvation within porous materials, I hope to 5089-22-5 help many people in the next few years. Safety of 1,4-Bis(benzo[d]oxazol-2-yl)naphthalene.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem