New research progress on 709-63-7 in 2021. 709-63-7, Name is 4-(Trifluoromethyl)acetophenone, molecular formula is C9H7F3O, Formula: https://www.ambeed.com/products/709-63-7.html, SMILES is C1=C(C=CC(=C1)C(C)=O)C(F)(F)F belongs to naphthyridine compound, is a common compound. In a patnet, author is Hirama, Yasuyuki, once mentioned the new application about 709-63-7.
The synthesis and thermal stability of oligodeoxynucleotides (ODNs) containing 4-amino-2,3,5,6-tetraazabenzo[cd]azulen-7-one nucleosides 5 (BaON) with the aim of developing new base pairing motif is described. The tricyclic nucleoside 5 was prepared starting with the 7-deaza-7-iodopurine derivative 1 via a palladium catalyzed cross-coupling reaction with methyl acrylate, followed by an intramolecular cyclization. The resulting nucleoside was incorporated into ODNs, and the base pairing property of the BaON: NaNO (2-amino-7-hydroxy-1,8-naphthyridine nucleoside) pair in the duplex was evaluated by a thermal denaturation study. The melting temperature (T-m) of the duplex containing the BaON: NaNO pair showed a higher value than that of the duplexes containing the adenine: thymine (A:T) and the guanine: cytosine (G:C) pairs, however it was lower than that of the ImO(N): NaNO (ImO(N) = 7-amino-imidazo[5′,4′:4,5]pyrido[2,3-d]pyrimidin-4(5H)-one nucleoside) pair. A temperature-dependent H-1 NMR study revealed that the H-bonding ability of BaON was lower than that of ImO(N), which would explain why the BaON: NaNO pair was less thermally stable than the ImO(N): NaNO pair. (C) 2010 Elsevier Ltd. All rights reserved.
These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 709-63-7, Formula: https://www.ambeed.com/products/709-63-7.html.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem