New Advances in Chemical Research in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. In an article, author is Sharma, B. K., once mentioned the application of 1631-25-0, Name is N-Cyclohexylmaleimide, molecular formula is C10H13NO2. Now introduce a scientific discovery about this category, Name: N-Cyclohexylmaleimide.
The affinity profiles for the bovine adenosine receptors, A(1) and A(2A), of a series of 1,8-naphthyridine derivatives were quantitatively analyzed using physicochemical and structural parameters of the substituents, present at varying positions of the molecules. The derived significant correlation, for bovine A(1) receptor, suggested that a R-1 substituent having a higher van der Waals volume, a R-2 substituent being a hydrogen-bond donor and a R-3 substituent able to transmit a higher field effect are helpful in augmenting the pK(i) of a compound. Similarly the study, pertaining to bovine A(2A) receptor, revealed that a less bulky substituent at R-2 and a strong electron-withdrawing substituent at R-3 are desirable in improving the binding affinity of a compound while substituents at R-1 remain insignificant to any interaction.
Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. Welcome to check out more blogs about 1631-25-0, in my other articles. Name: N-Cyclohexylmaleimide.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem