New Advances in Chemical Research in 2021. In an article, author is Lerchen, Andreas, once mentioned the application of 709-63-7, Name is 4-(Trifluoromethyl)acetophenone, molecular formula is C9H7F3O, molecular weight is 188.15, category is naphthyridine. Now introduce a scientific discovery about this category, Quality Control of 4-(Trifluoromethyl)acetophenone.
(-)-Finerenone is a nonsteroidal mineralocorticoid receptor antagonist currently in phase III clinical trials for the treatment of chronic kidney disease in type 2 diabetes. It contains an unusual dihydronaphthyridine core. We report a 6-step synthesis of (-)-finerenone, which features an enantioselective partial transfer hydrogenation of a naphthyridine using a chiral phosphoric acid catalyst with a Hantzsch ester. The process is complicated by the fact that the naphthyridine exists as a mixture of two atropisomers that react at different rates and with different selectivities. The intrinsic kinetic resolution was converted into a kinetic dynamic resolution at elevated temperature, which enabled us to obtain (-)-finerenone in both high yield and high enantioselectivity. DFT calculations have revealed the origin of selectivity.
The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In my other articles, you can also check out more blogs about 709-63-7. Quality Control of 4-(Trifluoromethyl)acetophenone.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem