With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.249889-68-7,8-Chloro-2-methoxy-1,5-naphthyridine,as a common compound, the synthetic route is as follows.,249889-68-7
Example 81 : (S)-3-(2,3-dihydro-benzo [ 1 ,4] dioxin-6-yl)-5- { [2-(6-methoxy- [l,5]naphthyridin-4-ylamino)-ethylamino]-methyl}-oxazolidin-2-one:; 81. i. N1 -(6-methoxy-fl, 5]naphthyridin-4-yl)-ethane-l,2-diamine:; A mixture of 8-chloro-2-methoxy-l,5-naphthyridine (1.71 g, 8.81 mmol) and ethylenediamine (1.18 mL, 2 eq.) was heated slowly to 800C over 1 h and subsequently up to 1000C for 2 h. After cooling to rt, the yellow solution was taken in DCM and successively washed with NaHCO3. The aq. layer was back extracted with DCM (3 times) and the combined org. layers were concentrated to afford the title intermediate as a pale yellow oil (0.98 g, 51% yield). MS (ESI, m/z): 219.4 [M+H+].
249889-68-7 8-Chloro-2-methoxy-1,5-naphthyridine 22244395, anaphthyridine compound, is more and more widely used in various fields.
Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; WO2008/126024; (2008); A2;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem