Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 1631-25-0, Name is N-Cyclohexylmaleimide, SMILES is O=C(C=C1)N(C2CCCCC2)C1=O, belongs to naphthyridines compound. In a document, author is Sharma, B. K., introduce the new discover, Application In Synthesis of N-Cyclohexylmaleimide.
Quantitative structure-activity relationship study on affinity profile of a series of 1,8-naphthyridine antagonists toward bovine adenosine receptors
The affinity profiles for the bovine adenosine receptors, A(1) and A(2A), of a series of 1,8-naphthyridine derivatives were quantitatively analyzed using physicochemical and structural parameters of the substituents, present at varying positions of the molecules. The derived significant correlation, for bovine A(1) receptor, suggested that a R-1 substituent having a higher van der Waals volume, a R-2 substituent being a hydrogen-bond donor and a R-3 substituent able to transmit a higher field effect are helpful in augmenting the pK(i) of a compound. Similarly the study, pertaining to bovine A(2A) receptor, revealed that a less bulky substituent at R-2 and a strong electron-withdrawing substituent at R-3 are desirable in improving the binding affinity of a compound while substituents at R-1 remain insignificant to any interaction.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1631-25-0 is helpful to your research. Application In Synthesis of N-Cyclohexylmaleimide.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem